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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Rnf146
ring finger protein 146
MGI:1915281
38 phenotypes from 1 allele in 2 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Rnf146tm1.1Rtpl/Rnf146tm1.1Rtpl
Lyz2tm1(cre)Ifo/Lyz2+
involves: 129P2/OlaHsd * C57BL/6J 		abnormal compact bone morphology J:243612
abnormal osteoclast differentiation J:243612
decreased bone mineral density J:243612
decreased bone trabecula number J:243612
decreased compact bone thickness J:243612
decreased trabecular bone mass J:243612
decreased trabecular bone volume J:243612
increased bone trabecular spacing J:243612
increased circulating tumor necrosis factor level J:243612
increased osteoclast cell number J:243612
normal skeleton phenotype J:243612
Rnf146tm1.1Rtpl/Rnf146tm1.1Rtpl
Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
involves: C57BL/6J * CD-1 		abnormal alveolar process morphology J:244583
abnormal ameloblast differentiation J:244583
abnormal endochondral bone ossification J:244583
abnormal intramembranous bone ossification J:244583
abnormal limb long bone morphology J:244583
abnormal rib morphology J:244583
clavicle hypoplasia J:244583
decreased bone mineral density J:244583
decreased bone mineralization J:244583
decreased bone ossification J:244583
decreased bone trabecula number J:244583
decreased circulating insulin level J:244583
decreased circulating osteocalcin level J:244583
decreased compact bone thickness J:244583
decreased compact bone volume J:244583
decreased insulin secretion J:244583
decreased osteoblast cell number J:244583
decreased osteoblast proliferation J:244583
decreased pancreatic islet number J:244583
decreased trabecular bone volume J:244583
impaired glucose tolerance J:244583
impaired osteoblast differentiation J:244583
increased bone marrow adipose tissue amount J:244583
increased bone trabecular spacing J:244583
increased circulating glucose level J:244583
increased circulating triglyceride level J:244583
increased total body fat amount J:244583
large anterior fontanelle J:244583
large posterior fontanelle J:244583
neonatal lethality, complete penetrance J:244583
respiratory distress J:244583
normal skeleton phenotype J:244583
small pancreatic islets J:244583
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory