Serpina12 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Serpina12
serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 12
MGI:1915304

20 phenotypes from 2 alleles in 2 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Serpina12^tm1Jwada/Serpina12⁺ B6JJcl.129P2-Serpina12^tm1Jwada	increased circulating leptin level	J:208508
	increased epididymal fat pad weight	J:208508
	increased fat cell size	J:208508
	increased liver triglyceride level	J:208508
Serpina12^tm1Jwada/Serpina12^tm1Jwada B6JJcl.129P2-Serpina12^tm1Jwada	abnormal fat cell morphology	J:208508
	normal homeostasis/metabolism phenotype	J:208508
	increased body weight	J:208508
	increased circulating cholesterol level	J:208508
	increased circulating LDL cholesterol level	J:208508
	increased circulating leptin level	J:208508
	increased epididymal fat pad weight	J:208508
	increased fat cell size	J:208508
	increased liver triglyceride level	J:208508
	increased liver weight	J:208508
	insulin resistance	J:208508
Tg(Fabp4-Serpina12)1Jwada/0 involves: C57BL/6JJcl	decreased body weight	J:208508
	decreased circulating insulin level	J:208508
	decreased circulating LDL cholesterol level	J:208508
	decreased circulating leptin level	J:208508
	decreased epididymal fat pad weight	J:208508
	decreased liver triglyceride level	J:208508
	decreased liver weight	J:208508
	decreased susceptibility to diet-induced hepatic steatosis	J:208508
	normal homeostasis/metabolism phenotype	J:208508
	increased insulin sensitivity	J:208508

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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