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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Cops8
COP9 signalosome subunit 8
MGI:1915363
18 phenotypes from 3 alleles in 4 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Cops8em1(IMPC)Ccpcz/Cops8+
C57BL/6NCrl-Cops8em1(IMPC)Ccpcz/Ccpcz 		abnormal heart morphology J:211773
abnormal spleen morphology J:211773
abnormal thymus morphology J:211773
enlarged heart J:211773
enlarged thymus J:211773
Cops8em1(IMPC)Ccpcz/Cops8em1(IMPC)Ccpcz
C57BL/6NCrl-Cops8em1(IMPC)Ccpcz/Ccpcz 		embryonic lethality prior to organogenesis J:211773
embryonic lethality prior to tooth bud stage J:211773
preweaning lethality, complete penetrance J:211773
Cops8tm1.1Nwe/Cops8tm1.1Nwe
involves: C57BL/6 		abnormal inner cell mass proliferation J:126339
decreased embryo size J:126339
embryonic growth retardation J:126339
prenatal lethality, complete penetrance J:126339
Cops8tm1Nwe/Cops8tm1.1Nwe
involves: 129S1/Sv * C57BL/6 		abnormal cell cycle J:126339
Cops8tm1Nwe/Cops8tm1.1Nwe
Tg(Cd4-cre)1Cwi/?
involves: 129S1/Sv * C57BL/6 * DBA/2 		abnormal CD4-positive, alpha-beta T cell physiology J:126339
abnormal T cell activation J:126339
decreased interleukin-2 secretion J:126339
decreased T cell number J:126339
decreased T cell proliferation J:126339
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory