Cops8 Phenotype Annotations

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Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Cops8
COP9 signalosome subunit 8
MGI:1915363

18 phenotypes from 3 alleles in 4 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Cops8^{em1(IMPC)Ccpcz}/Cops8⁺ C57BL/6NCrl-Cops8^{em1(IMPC)Ccpcz}/Ccpcz	abnormal heart morphology	J:211773
	abnormal spleen morphology	J:211773
	abnormal thymus morphology	J:211773
	enlarged heart	J:211773
	enlarged thymus	J:211773
Cops8^{em1(IMPC)Ccpcz}/Cops8^{em1(IMPC)Ccpcz} C57BL/6NCrl-Cops8^{em1(IMPC)Ccpcz}/Ccpcz	embryonic lethality prior to organogenesis	J:211773
	embryonic lethality prior to tooth bud stage	J:211773
	preweaning lethality, complete penetrance	J:211773
Cops8^tm1.1Nwe/Cops8^tm1.1Nwe involves: C57BL/6	abnormal inner cell mass proliferation	J:126339
	decreased embryo size	J:126339
	embryonic growth retardation	J:126339
	prenatal lethality, complete penetrance	J:126339
Cops8^tm1Nwe/Cops8^tm1.1Nwe involves: 129S1/Sv * C57BL/6	abnormal cell cycle	J:126339
Cops8^tm1Nwe/Cops8^tm1.1Nwe Tg(Cd4-cre)1Cwi/? involves: 129S1/Sv * C57BL/6 * DBA/2	abnormal CD4-positive, alpha-beta T cell physiology	J:126339
	abnormal T cell activation	J:126339
	decreased interleukin-2 secretion	J:126339
	decreased T cell number	J:126339
	decreased T cell proliferation	J:126339

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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