Ino80 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Ino80
INO80 complex subunit
MGI:1915392

34 phenotypes from 6 alleles in 7 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Ino80^tm1.1Jland/Ino80^tm1.1Jland B6.129(C3)-Ino80^tm1.1Jland/J	no abnormal phenotype detected	J:101977
Ino80^tm1.1Jland/Ino80^tm1.1Jland Pax7^tm1(cre)Mrc/Pax7⁺ involves: 129S1/Sv * 129X1/SvJ	normal muscle phenotype	J:306156
Ino80^tm1.1Schg/Ino80⁺ involves: C57BL/6J	decreased body size	J:221224
Ino80^tm1.1Schg/Ino80⁺ involves: C57BL/6J	limb grasping	J:221224
Ino80^tm1.1Schg/Ino80^tm1.1Schg involves: C57BL/6J	abnormal embryo development	J:221224
	embryonic growth retardation	J:221224
	embryonic lethality, incomplete penetrance	J:221224
	preweaning lethality, complete penetrance	J:221224
Ino80^tm1.2Jland/Ino80^tm1.2Jland B6.129(C)-Ino80^tm1.2Jland	absent anterior visceral endoderm	J:229516
	absent distal visceral endoderm	J:229516
	embryonic lethality between implantation and placentation, complete penetrance	J:229516
Ino80^{tm1a(EUCOMM)Hmgu}/Ino80⁺ C57BL/6N-Ino80^{tm1a(EUCOMM)Hmgu}/Ics	abnormal seminal vesicle morphology	J:211773
	abnormal vocalization	J:211773
	decreased exploration in new environment	J:211773
	decreased locomotor activity	J:211773
	increased aggression	J:211773
	prolonged QRS complex duration	J:211773
Ino80^{tm1a(EUCOMM)Hmgu}/Ino80^{tm1a(EUCOMM)Hmgu} C57BL/6N-Ino80^{tm1a(EUCOMM)Hmgu}/Ics	preweaning lethality, complete penetrance	J:211773
Ino80^{tm1b(EUCOMM)Hmgu}/Ino80^{tm1b(EUCOMM)Hmgu} C57BL/6N-Ino80^{tm1b(EUCOMM)Hmgu}/Ics	preweaning lethality, incomplete penetrance	J:211773
Ino80^tm1Schg/Ino80^tm1Schg Tg(CAG-cre/Esr1)5Amc/0 involves: C57BL/6 CBA	abnormal cell cycle	J:221224
	abnormal cell physiology	J:221224
	abnormal DNA repair	J:221224
	abnormal DNA replication	J:221224
	abnormal double-strand DNA break repair	J:221224
	abnormal response to radiation	J:221224
	abnormal telomere morphology	J:221224
	normal cellular phenotype	J:221224
	decreased body weight	J:221224
	decreased fibroblast proliferation	J:221224
	early cellular replicative senescence	J:221224
	increased cellular sensitivity to alkylating agents	J:221224
	increased cellular sensitivity to hydroxyurea	J:221224
	increased cellular sensitivity to ultraviolet irradiation	J:221224
	normal neoplasm	J:221224
	premature death	J:221224

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/17/2024 MGI 6.24