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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Wls
wntless WNT ligand secretion mediator
MGI:1915401
119 phenotypes from 9 alleles in 13 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Gt(ROSA)26Sortm1.1(Wls/YFP)Mbtr/Gt(ROSA)26Sor+
involves: C57BL/6 		decreased neutrophil cell number J:202499
Tg(Krt1-15-cre/PGR*)22Cot/0
Wlstm1.1Lan/Wlstm1.1Lan
involves: 129S6/SvEvTac * C57BL/6 * SJL 		normal integument phenotype J:204142
Tg(KRT5-rtTA)#Glk/0
Tg(tetO-cre)1Jaw/0
Wlstm1.1Lan/Wlstm1.1Lan
involves: 129S6/SvEvTac * C57BL/6 * FVB/N 		abnormal epidermal layer morphology J:204142
abnormal hair cycle catagen phase J:204142
abnormal hair follicle morphology J:204142
abnormal keratinocyte morphology J:204142
cutaneous mastocytosis J:204142
Wlsem1Jgg/Wlsem1Jgg
involves: C57BL/6J 		abnormal dentate gyrus morphology J:341542
abnormal nervous system development J:341542
abnormal neural tube closure J:341542
abnormal neuron differentiation J:341542
abnormal tail bud morphology J:341542
adactyly J:341542
decreased brain size J:341542
decreased caudal vertebrae number J:341542
decreased neuron number J:341542
hydronephrosis J:341542
perinatal lethality, complete penetrance J:341542
Wlsem2Jgg/Wlsem2Jgg
involves: C57BL/6J 		abnormal dentate gyrus morphology J:341542
abnormal nervous system development J:341542
abnormal neural tube closure J:341542
abnormal neuron differentiation J:341542
abnormal tail bud morphology J:341542
adactyly J:341542
decreased brain size J:341542
decreased caudal vertebrae number J:341542
decreased neuron number J:341542
hydronephrosis J:341542
perinatal lethality, complete penetrance J:341542
WlsGt(RRJ545)Byg/WlsGt(RRJ545)Byg
involves: 129P2/OlaHsd 		abnormal developmental patterning J:154679
abnormal ectoderm development J:154679
abnormal endoderm development J:154679
abnormal germ layer development J:154679
absent mesoderm J:154679
embryonic lethality during organogenesis, complete penetrance J:154679
failure of primitive streak formation J:154679
Wlstm1.1Arte/Wlstm1.1Arte
Krt14tm1(cre)Wbm/Krt14+
involves: 129P2/OlaHsd * C57BL/6 		abnormal adipose tissue physiology J:202499
abnormal ear morphology J:202499
abnormal eye morphology J:202499
abnormal hair growth J:202499
abnormal nose morphology J:202499
abnormal skin appearance J:202499
abnormal skin physiology J:202499
abnormal T cell differentiation J:202499
abnormal T cell physiology J:202499
abnormal T cell subpopulation ratio J:202499
cutaneous mastocytosis J:202499
decreased body size J:202499
decreased body surface temperature J:202499
decreased double-positive T cell number J:202499
decreased gamma-delta T cell number J:202499
decreased hair follicle number J:202499
decreased T cell number J:202499
decreased thymus weight J:202499
epidermal spongiosis J:202499
flaky skin J:202499
hair follicle degeneration J:202499
impaired skin barrier function J:202499
increased double-negative T cell number J:202499
increased keratinocyte proliferation J:202499
increased macrophage cell number J:202499
increased neutrophil cell number J:202499
increased T cell proliferation J:202499
postnatal growth retardation J:202499
premature death J:202499
reddish skin J:202499
scaly skin J:202499
skin inflammation J:202499
small thymus medulla J:202499
sparse hair J:202499
thin dermal layer J:202499
thin hypodermis J:202499
thin skin J:202499
thymus atrophy J:202499
thymus hypoplasia J:202499
Wlstm1.1Arte/Wlstm1.1Arte
Tg(CMV-cre)1Cgn/?
involves: BALB/cJ * C57BL/6 		embryonic lethality, complete penetrance J:202499
Wlstm1.1Arte/Wlstm1.1Arte
Tg(Foxn1-cre)1Tbo/0
involves: C57BL/6 		normal immune system phenotype J:202499
normal integument phenotype J:202499
sparse hair J:202499
Wlstm1.1Lan/Wlstm1.1Lan
H2az2Tg(Wnt1-cre)11Rth/H2az2+
involves: 129S/SvEv * C57BL/6J * CBA/J * SJL 		abnormal metencephalon morphology J:164701
abnormal neural tube morphology J:164701
absent cerebellum J:164701
absent choroid plexus J:164701
absent midbrain J:164701
absent midbrain-hindbrain boundary J:164701
decreased forebrain size J:164701
perinatal lethality J:164701
short rostral-caudal axis J:164701
Wlstm1.1Lan/Wlstm1.1Lan
Tg(EIIa-cre)C5379Lmgd/0
involves: 129S/SvEv * FVB/N * SJL 		embryonic growth arrest J:164701
embryonic lethality between implantation and somite formation, incomplete penetrance J:164701
failure of primitive streak formation J:164701
Wlstm1.1Lan/Wlstm1.1Lan
Tg(Pdx1-cre)6Tuv/0
involves: 129S/SvEv * FVB/N * SJL 		pancreas hypoplasia J:164701
Wlstm1.1Whsu/Wlstm1.1Whsu
H2az2Tg(Wnt1-cre)11Rth/H2az2+
involves: 129S6/SvEvTac * C57BL/6J * CBA/J 		abnormal brain morphology J:167835
abnormal cranial nerve morphology J:167835
abnormal craniofacial development J:167835
abnormal craniofacial morphology J:167835
abnormal hindbrain development J:167835
abnormal midbrain development J:167835
abnormal midbrain-hindbrain boundary development J:167835
abnormal neurocranium morphology J:167835
abnormal salivary gland morphology J:167835
abnormal serous gland morphology J:167835
abnormal tooth morphology J:167835
abnormal viscerocranium morphology J:167835
absent cerebellum J:167835
absent choroid plexus J:167835
absent tectum J:167835
absent tegmentum J:167835
cleft palate J:167835
Wlstm1.2Whsu/Wlstm1.2Whsu
involves: 129S6/SvEvTac 		abnormal rostral-caudal axis patterning J:167835
absent mesoderm J:167835
embryonic growth arrest J:167835
embryonic lethality during organogenesis, complete penetrance J:167835
failure of primitive streak formation J:167835
Wlstm1Xzg/Wlstm1Xzg
Tg(Msx2-cre)5Rem/0
Not Specified 		abnormal apical ectodermal ridge morphology J:184918
abnormal dermal layer morphology J:184918
abnormal forelimb morphology J:184918
abnormal forelimb stylopod morphology J:184918
abnormal hair follicle development J:184918
abnormal hindlimb morphology J:184918
abnormal hindlimb zeugopod morphology J:184918
abnormal ligament morphology J:184918
abnormal limb development J:184918
abnormal muscle development J:184918
abnormal tendon morphology J:184918
decreased autopod size J:184918
decreased cell proliferation J:184918
delayed cranial suture closure J:184918
increased apoptosis J:184918
oligodactyly J:184918
short fibula J:184918
short limbs J:184918
short tibia J:184918
thin apical ectodermal ridge J:184918
Wlstm1Xzg/Wlstm1Xzg
Tg(Prrx1-cre)1Cjt/0
involves: C57BL/6J * SJL/J 		abnormal digit development J:184918
abnormal limb development J:184918
abnormal skeleton morphology J:184918
adipsia J:184918
chondrodystrophy J:184918
decreased autopod size J:184918
decreased cell proliferation J:184918
delayed bone ossification J:184918
increased apoptosis J:184918
lethality at weaning, incomplete penetrance J:184918
short limbs J:184918
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory