Nadk2 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Nadk2
NAD kinase 2, mitochondrial
MGI:1915896

26 phenotypes from 3 alleles in 3 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Nadk2^em1(IMPC)J/Nadk2⁺ C57BL/6NJ-Nadk2^em1(IMPC)J/J	decreased fasting circulating glucose level	J:211773
	increased mean corpuscular hemoglobin concentration	J:211773
	persistence of hyaloid vascular system	J:211773
Nadk2^em1(IMPC)J/Nadk2^em1(IMPC)J C57BL/6NJ-Nadk2^em1(IMPC)J/J	abnormal embryo turning	J:211773
	embryonic lethality prior to tooth bud stage	J:211773
	preweaning lethality, complete penetrance	J:211773
Nadk2^{tm1a(EUCOMM)Wtsi}/Nadk2^{tm1a(EUCOMM)Wtsi} involves: C57BL/6N * C57BL/6NTac	abnormal liver physiology	J:255700
	decreased energy expenditure	J:255700
	decreased fatty acid oxidation	J:255700
	enlarged liver	J:255700
	hepatic steatosis	J:255700
	increased circulating carnitine level	J:255700
	increased circulating free fatty acids level	J:255700
	increased circulating lysine level	J:255700
	increased circulating triglyceride level	J:255700
	increased liver triglyceride level	J:255700
	increased lysine level	J:255700
	increased respiratory quotient	J:255700
	liver degeneration	J:255700
	liver fibrosis	J:255700
	oxidative stress	J:255700
	pale liver	J:255700
Nadk2^{tm1b(EUCOMM)Wtsi}/Nadk2⁺ C57BL/6N-Nadk2^{tm1b(EUCOMM)Wtsi}/Wtsi	abnormal coat/hair pigmentation	J:211773
Nadk2^{tm1b(EUCOMM)Wtsi}/Nadk2^{tm1b(EUCOMM)Wtsi} C57BL/6N-Nadk2^{tm1b(EUCOMM)Wtsi}/Wtsi	abnormal placenta morphology	J:261316
	abnormal trophoblast layer morphology	J:261316
	lethality throughout fetal growth and development, complete penetrance	J:261316
	preweaning lethality, complete penetrance	J:211773

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