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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Smpdl3b
sphingomyelin phosphodiesterase, acid-like 3B
MGI:1916022
9 phenotypes from 1 allele in 2 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Smpdl3btm1a(EUCOMM)Wtsi/Smpdl3btm1a(EUCOMM)Wtsi
C57BL/6-Smpdl3btm1a(EUCOMM)Wtsi 		abnormal chemokine secretion J:224870
abnormal circulating chemokine level J:224870
abnormal macrophage morphology J:224870
increased circulating interleukin-6 level J:224870
increased circulating interleukin-12b level J:224870
increased circulating tumor necrosis factor level J:224870
increased neutrophil cell number J:224870
increased susceptibility to endotoxin shock J:224870
Smpdl3btm1a(EUCOMM)Wtsi/Smpdl3btm1a(EUCOMM)Wtsi
Not Specified 		decreased locomotor activity J:165965
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory