Prickle1 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Prickle1
prickle planar cell polarity protein 1
MGI:1916034

88 phenotypes from 8 alleles in 7 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Prickle1^b2b019Clo/Prickle1^b2b019Clo C57BL/6J-Prickle1^b2b019Clo	cleft palate	J:175213
	double outlet right ventricle, ventricular defect committed to aorta	J:175213
	microcephaly	J:175213
	micrognathia	J:175213
	perimembraneous ventricular septal defect	J:175213
Prickle1^em1Yzou/Prickle1⁺ C57BL/6-Prickle1^em1Yzou	abnormal excitatory synapse morphology	J:321396
	abnormal social investigation	J:321396
	abnormal spatial reference memory	J:321396
	increased susceptibility to pharmacologically induced seizures	J:321396
Prickle1^em1Yzou/Prickle1^em1Yzou C57BL/6-Prickle1^em1Yzou	abnormal excitatory synapse morphology	J:321396
	abnormal object recognition memory	J:321396
	abnormal social investigation	J:321396
Prickle1^m1Ingm/Prickle1⁺ involves: C57BL/6	abnormal seizure response to electrical stimulation	J:169136
Prickle1^m1Ingm/Prickle1^m1Ingm involves: C57BL/6	normal mortality/aging	J:169136
Prickle1^m2Ingm/Prickle1⁺ C57BL/6-Prickle1^m2Ingm	abnormal seizure response to electrical stimulation	J:169136
Prickle1^m2Ingm/Prickle1^m2Ingm C57BL/6-Prickle1^m2Ingm	abnormal palatal mesenchymal cell proliferation	J:223183
	abnormal palatal rugae morphology	J:223183
	abnormal palatal shelf morphology	J:223183
	abnormal secondary palate development	J:223183
	cleft secondary palate	J:223183
	decreased maxillary shelf size	J:223183
	decreased palatal shelf size	J:223183
	failure of palatal shelf elevation	J:223183
	palatal shelves fail to meet at midline	J:223183
	prenatal lethality, complete penetrance	J:169136
	short snout	J:223183
Prickle1^tm1.2Asw/Prickle1^tm1.2Asw Not Specified	abnormal chondrocyte morphology	J:213772
	abnormal cochlear hair cell stereociliary bundle morphology	J:213772
	abnormal developmental patterning	J:213772
	abnormal digit morphology	J:213772
	abnormal fetal cardiomyocyte morphology	J:213772
	abnormal hair follicle morphology	J:213772
	abnormal hair follicle orientation	J:213772
	abnormal hippocampus morphology	J:213772
	abnormal innervation	J:213772
	abnormal kidney collecting duct morphology	J:213772
	abnormal kidney morphology	J:213772
	abnormal myocardial fiber morphology	J:213772
	abnormal nervous system tract morphology	J:213772
	abnormal nose morphology	J:213772
	abnormal phalanx morphology	J:213772
	abnormal proximal convoluted tubule morphology	J:213772
	abnormal renal tubule morphology	J:213772
	abnormal striatum morphology	J:213772
	abnormal ureteric bud morphology	J:213772
	atrial septal defect	J:213772
	bifid tongue	J:213772
	cleft palate	J:213772
	decreased body size	J:213772
	decreased length of long bones	J:213772
	delayed endochondral bone ossification	J:213772
	delayed neural tube closure	J:213772
	dilated renal tubule	J:213772
	embryonic lethality during organogenesis, incomplete penetrance	J:213772
	enlarged lateral ventricles	J:213772
	eyelids open at birth	J:213772
	increased diameter of long bones	J:213772
	increased heart right atrium size	J:213772
	kidney cyst	J:213772
	misaligned sternebrae	J:213772
	postnatal lethality, complete penetrance	J:213772
	short cochlear hair cell stereocilia	J:213772
	short forelimb	J:213772
	short limbs	J:213772
	short mandible	J:213772
	short nasal bone	J:213772
	short premaxilla	J:213772
	short snout	J:213772
	short tail	J:213772
	short tongue	J:213772
	transposition of great arteries	J:213772
	wavy tail	J:213772
Prickle1^tm1.2Asw/Prickle1^tm1.3Asw Edil3^{Tg(Sox2-cre)1Amc}/Edil3⁺ involves: C57BL/6 * CBA	abnormal hair follicle development	J:213772
	abnormal hair follicle orientation	J:213772
Prickle1^tm1.3Asw/Prickle1^tm1.3Asw Edil3^{Tg(Sox2-cre)1Amc}/Edil3⁺ involves: C57BL/6 * CBA	postnatal lethality, complete penetrance	J:213772
Prickle1^tm1Asw/Prickle1^tm1.2Asw Not Specified	abnormal eyelid cilium morphology	J:213772
	abnormal eyelid morphology	J:213772
	abnormal vertebrae development	J:213772
	brachydactyly	J:213772
	decreased body length	J:213772
	decreased length of long bones	J:213772
	flattened snout	J:213772
	fused lower incisors	J:213772
	kinked tail	J:213772
	ocular hypertelorism	J:213772
	prominent forehead	J:213772
	short snout	J:213772
Prickle1^tm1Asw/Prickle1^tm1Asw Not Specified	abnormal eyelid cilium morphology	J:213772
	abnormal eyelid morphology	J:213772
	abnormal vertebrae development	J:213772
	brachydactyly	J:213772
	decreased body length	J:213772
	decreased length of long bones	J:213772
	flattened snout	J:213772
	fused lower incisors	J:213772
	ocular hypertelorism	J:213772
	prominent forehead	J:213772
	short snout	J:213772
Prickle1^tm1Nue/Prickle1⁺ B6.Cg-Prickle1^tm1Nue	abnormal seizure response to electrical stimulation	J:169136
Prickle1^tm1Nue/Prickle1^tm1Nue involves: C57BL/6 * CBA	abnormal anterior visceral endoderm cell migration	J:151993
	abnormal embryonic epiblast morphology	J:151993
	abnormal extraembryonic endoderm formation	J:151993
	abnormal mitotic spindle morphology	J:151993
	absent mesoderm	J:151993
	decreased mitotic index	J:151993
	embryonic growth arrest	J:151993
	embryonic lethality between somite formation and embryo turning, complete penetrance	J:151993
	failure of primitive streak formation	J:151993
	increased embryonic tissue cell apoptosis	J:151993

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24