Chmp2b Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Chmp2b
charged multivesicular body protein 2B
MGI:1916192

25 phenotypes from 3 alleles in 4 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Chmp2b^em1(IMPC)Mbp/Chmp2b⁺ C57BL/6NCrl-Chmp2b^em1(IMPC)Mbp/MbpMmucd	no spontaneous movement	J:211773
Chmp2b^em1(IMPC)Mbp/Chmp2b⁺ C57BL/6NCrl-Chmp2b^em1(IMPC)Mbp/Mmucd	abnormal kidney morphology	J:211773
	abnormal liver morphology	J:211773
	abnormal skin morphology	J:211773
	abnormal spleen morphology	J:211773
	abnormal testis morphology	J:211773
	abnormal uterus morphology	J:211773
	decreased heart rate	J:211773
	enlarged spleen	J:211773
	hydrometra	J:211773
	no spontaneous movement	J:211773
	prolonged RR interval	J:211773
	small kidney	J:211773
	small testis	J:211773
Chmp2b^em1(IMPC)Mbp/Chmp2b^em1(IMPC)Mbp C57BL/6NCrl-Chmp2b^em1(IMPC)Mbp/MbpMmucd	no spontaneous movement	J:211773
Chmp2b^em1(IMPC)Mbp/Chmp2b^em1(IMPC)Mbp C57BL/6NCrl-Chmp2b^em1(IMPC)Mbp/Mmucd	no spontaneous movement	J:211773
	preweaning lethality, incomplete penetrance	J:211773
Chmp2b^Gt(XL952)Byg/Chmp2b^Gt(XL952)Byg involves: 129P2/OlaHsd * C57BL/6	abnormal dendritic spine morphology	J:219860
	abnormal hippocampus CA1 region morphology	J:219860
	abnormal synapse morphology	J:219860
Chmp2b^tm1.1Hiok/Chmp2b⁺ involves: C57BL/6J	abnormal cell cycle checkpoint function	J:308471
	abnormal cerebral cortex morphology	J:308471
	abnormal endoplasmic reticulum morphology	J:308471
	abnormal frontal lobe morphology	J:308471
	abnormal primary motor cortex morphology	J:308471
	cellular necrosis	J:308471
	impaired spatial learning	J:308471
	increased anxiety-related response	J:308471

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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