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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Ubr4
ubiquitin protein ligase E3 component n-recognin 4
MGI:1916366
32 phenotypes from 5 alleles in 5 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Ubr4Tg(Tyr)2393A-1Ove/Ubr4Tg(Tyr)2393A-1Ove
FVB/N-Ubr4Tg(Tyr)2393A-1Ove 		decreased birth body size J:175597
neonatal lethality, complete penetrance J:175597
Ubr4tm1.1Nkt/Ubr4tm1.1Nkt
involves: 129S6/SvEvTac * C57BL/6 * FVB/N 		abnormal placental labyrinth vasculature morphology J:203460
decreased embryo size J:203460
embryonic lethality during organogenesis, complete penetrance J:203460
thin placenta labyrinth J:203460
Ubr4tm1.1Ytkw/Ubr4tm1.1Ytkw
involves: 129P2/OlaHsd 		abnormal autophagy J:196073
abnormal vitelline vascular remodeling J:196073
abnormal vitelline vasculature morphology J:196073
embryonic growth arrest J:196073
embryonic lethality during organogenesis, complete penetrance J:196073
pale yolk sac J:196073
Ubr4tm1.2Nkt/Ubr4tm1.2Nkt
Edil3Tg(Sox2-cre)1Amc/Edil3+
involves: 129S6/SvEvTac * C57BL/6 * CBA * SJL 		abnormal atrioventricular cushion morphology J:203460
abnormal brain morphology J:203460
abnormal cell death J:203460
abnormal fourth ventricle morphology J:203460
abnormal head morphology J:203460
abnormal heart development J:203460
abnormal interventricular septum morphology J:203460
abnormal lateral ganglionic eminence morphology J:203460
abnormal liver parenchyma morphology J:203460
abnormal liver vasculature morphology J:203460
abnormal medial ganglionic eminence morphology J:203460
decreased brain size J:203460
dilated liver sinusoidal space J:203460
normal embryo phenotype J:203460
embryonic growth retardation J:203460
increased cell proliferation J:203460
lethality throughout fetal growth and development, complete penetrance J:203460
liver hypoplasia J:203460
thin ventricular wall J:203460
Ubr4tm1b(EUCOMM)Hmgu/Ubr4tm1b(EUCOMM)Hmgu
C57BL/6N-Ubr4tm1b(EUCOMM)Hmgu/Bay 		embryonic lethality prior to tooth bud stage J:211773
preweaning lethality, complete penetrance J:211773
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory