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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Commd10
COMM domain containing 10
MGI:1916706
243 phenotypes from multigenic genotypes
Export: Excel File
Allelic Composition
Genetic Background		 Annotated Term Reference
A930024E05Rikem2Zfa/A930024E05Rikem2Zfa
Commd10Tg(Vav1-icre)A2Kio/Commd10+
involves: C57BL/6 * C57BL/10 * CBA/Ca 		decreased common lymphocyte progenitor cell number J:259392
normal immune system phenotype J:259392
Adgrf5tm1.1Bstc/Adgrf5tm1.2Bstc
Commd10Tg(Vav1-icre)A2Kio/Commd10+
involves: 129S4/SvJae * C57BL/6J * C57BL/10 * CBA/Ca 		normal respiratory system phenotype J:196943
Adh5tm1.1Llli/Adh5tm1.1Llli
Commd10Tg(Vav1-icre)A2Kio/Commd10+
B6.Cg-Adh5tm1.1Llli Commd10Tg(Vav1-icre)A2Kio 		normal mortality/aging J:173666
Atg7tm1Tchi/Atg7tm1Tchi
Commd10Tg(Vav1-icre)A2Kio/Commd10+
involves: C57BL/6NCrlj * C57BL/10 * CBA/Ca * CBA/JNCrlj 		abnormal common lymphocyte progenitor cell morphology J:176843
abnormal hematopoietic stem cell morphology J:176843
abnormal hematopoietic stem cell physiology J:176843
abnormal leukocyte morphology J:176843
decreased B cell number J:176843
decreased bone marrow cell number J:176843
decreased common myeloid progenitor cell number J:176843
decreased hematopoietic stem cell number J:176843
decreased leukocyte cell number J:176843
decreased NK cell number J:176843
decreased T cell number J:176843
Atp6v0a2tm1Kdb/Atp6v0a2tm1Kdb
Commd10Tg(Vav1-icre)A2Kio/Commd10+
involves: C57BL/6 * C57BL/10 * CBA/Ca 		abnormal CD8-positive, alpha-beta cytotoxic T cell morphology J:274048
decreased alpha-beta T cell number J:274048
decreased CD4-positive, alpha-beta T cell number J:274048
decreased T cell number J:274048
decreased tumor latency J:274048
increased incidence of induced tumors J:274048
increased metastatic potential J:274048
Bcl11atm1Pwt/Bcl11atm1Pwt
Commd10Tg(Vav1-icre)A2Kio/Commd10+
involves: C57BL/6 * C57BL/10 * CBA/Ca 		decreased B cell number J:207383
decreased circulating interferon-alpha level J:207383
decreased hematopoietic stem cell number J:207383
decreased plasmacytoid dendritic cell number J:207383
normal hematopoietic system phenotype J:207383
Bcortm1.1Vjba/Y
Commd10Tg(Vav1-icre)A2Kio/Commd10+
involves: 129S1/Sv * C57BL/6 * CBA/Ca 		increased neutrophil cell number J:231455
Bmi1tm1Sgon/Bmi1tm1Sgon
Commd10Tg(Vav1-icre)A2Kio/?
involves: 129S1/Sv * 129X1/SvJ * C57BL/10 * CBA/Ca 		abnormal erythropoiesis J:221849
abnormal hemopoiesis J:221849
abnormal immune system cell morphology J:221849
abnormal immune system organ morphology J:221849
abnormal spleen morphology J:221849
abnormal spleen periarteriolar lymphoid sheath morphology J:221849
abnormal spleen white pulp morphology J:221849
abnormal thymus morphology J:221849
absent spleen germinal center J:221849
decreased B cell number J:221849
decreased bone marrow cell number J:221849
decreased common myeloid progenitor cell number J:221849
decreased hematopoietic stem cell number J:221849
decreased myeloid cell number J:221849
decreased spleen red pulp amount J:221849
decreased spleen white pulp amount J:221849
decreased T cell number J:221849
increased common lymphocyte progenitor cell number J:221849
premature death J:221849
small spleen J:221849
small thymus J:221849
thymus atrophy J:221849
Brpf1tm1c(EUCOMM)Wtsi/Brpf1tm1c(EUCOMM)Wtsi
Commd10Tg(Vav1-icre)A2Kio/Commd10+
involves: C57BL/6J * C57BL/6N * C57BL/10 * CBA/Ca 		abnormal cell physiology J:240552
Cd40lgtm1Parl/Cd40lgtm1Parl
Commd10Tg(Vav1-icre)A2Kio/Commd10+
involves: 129 * C57BL/6 * C57BL/10 * CBA/Ca 		decreased IgM level J:213459
normal hematopoietic system phenotype J:213459
normal homeostasis/metabolism phenotype J:213459
increased IgG1 level J:213459
thrombocytopenia J:213459
Cd40lgtm1Parl/Y
Commd10Tg(Vav1-icre)A2Kio/Commd10+
involves: 129 * C57BL/6 * C57BL/10 * CBA/Ca 		decreased IgM level J:213459
normal hematopoietic system phenotype J:213459
normal homeostasis/metabolism phenotype J:213459
increased IgG1 level J:213459
thrombocytopenia J:213459
Cdh5tm8Dvst/Cdh5tm8Dvst
Commd10Tg(Vav1-icre)A2Kio/Commd10+
involves: C57BL/10 * CBA/Ca 		normal liver/biliary system phenotype J:213676
Cdk5rap3tm1c(EUCOMM)Hmgu/Cdk5rap3tm1c(EUCOMM)Hmgu
Commd10Tg(Vav1-icre)A2Kio/Commd10+
involves: 129S4/SvJaeSor * C57BL/6N * C57BL/10 * CBA/Ca 		abnormal hemopoiesis J:272566
normal mortality/aging J:272566
Cdkn1atm1Led/Cdkn1atm1Led
Zbtb17tm1Cksn/Zbtb17tm1Cksn
Commd10Tg(Vav1-icre)A2Kio/Commd10+
B6.Cg-Zbtb17tm1Cksn Cdkn1atm1Led Commd10Tg(Vav1-icre)A2Kio 		arrested T cell differentiation J:170508
Chaf1btm2c(EUCOMM)Hmgu/Chaf1b+
Commd10Tg(Vav1-icre)A2Kio/Commd10+
involves: C57BL/6J * C57BL/6N * C57BL/10 * CBA/Ca 		abnormal bone marrow cell morphology/development J:266848
decreased bone marrow cell number J:266848
decreased hematopoietic stem cell number J:266848
Chaf1btm2c(EUCOMM)Hmgu/Chaf1btm2c(EUCOMM)Hmgu
Commd10Tg(Vav1-icre)A2Kio/Commd10+
involves: C57BL/6J * C57BL/6N * C57BL/10 * CBA/Ca 		prenatal lethality, complete penetrance J:266848
Commd10Tg(Vav1-icre)A2Kio/Commd10+
Ociad1tm1Msin/Ociad1tm1Msin
involves: C57BL/6NCrlj * C57BL/10 * CBA/Ca * CBA/JNCrlj 		increased hematopoietic cell number J:279239
increased hematopoietic stem cell number J:279239
Commd10Tg(Vav1-icre)A2Kio/0
Map3k7tm1.1Arte/Map3k7tm1.1Arte
involves: C57BL/10 * C57BL/6J * C57BL/6NTac * CBA/Ca 		decreased interleukin-6 secretion J:332172
decreased interleukin-10 secretion J:332172
decreased interleukin-12b secretion J:332172
decreased macrophage cell number J:332172
decreased tumor necrosis factor secretion J:332172
enlarged axillary lymph nodes J:332172
enlarged inguinal lymph nodes J:332172
enlarged spleen J:332172
increased B cell number J:332172
increased lymphocyte cell number J:332172
increased neutrophil cell number J:332172
increased splenocyte number J:332172
Commd10Tg(Vav1-icre)A2Kio/0
Nfil3tm1.2Kubo/Nfil3tm1.2Kubo
involves: 129 * C57BL/6 * C57BL/10 * CBA/Ca 		decreased dendritic cell number J:334296
Commd10Tg(Vav1-icre)A2Kio/?
Tnfrsf14tm1.1Kro/Tnfrsf14tm1.1Kro
involves: C57BL/6NCrl * C57BL/10 * CBA * SJL 		abnormal blinking J:243038
decreased susceptibility to Herpesvirales infection J:243038
Ctps1tm1c(KOMP)Wtsi/Ctps1tm1c(KOMP)Wtsi
Commd10Tg(Vav1-icre)A2Kio/0
B6.Cg-Ctps1tm1c(KOMP)Wtsi Commd10Tg(Vav1-icre)A2Kio 		abnormal spleen morphology J:348981
anemia J:348981
decreased B cell number J:348981
decreased body size J:348981
decreased bone marrow cell number J:348981
decreased double-positive T cell number J:348981
decreased hematopoietic stem cell number J:348981
decreased megakaryocyte-erythroid progenitor cell number J:348981
decreased NK cell number J:348981
decreased T cell number J:348981
decreased T cell proliferation J:348981
increased CD4-positive, alpha-beta T cell number J:348981
increased CD8-positive, alpha-beta T cell number J:348981
premature death J:348981
prenatal lethality, incomplete penetrance J:348981
small thymus J:348981
thymus hypoplasia J:348981
Cxcl12tm1.1Sjm/Cxcl12tm1.1Sjm
Commd10Tg(Vav1-icre)A2Kio/?
involves: C57BL/6 * C57BL/10 * CBA/Ca 		normal hematopoietic system phenotype J:194748
Dhx36tm1.2Pmt/Dhx36tm1.2Pmt
Commd10Tg(Vav1-icre)A2Kio/Commd10+
involves: 129P2/Ola * 129S4/SvJaeSor * C57BL/6 * C57BL/10 * CBA/Ca 		abnormal cell cycle J:185179
abnormal erythrocyte physiology J:185179
abnormal erythropoiesis J:185179
abnormal proerythroblast morphology J:185179
anemia J:185179
decreased erythroblast number J:185179
decreased erythrocyte cell number J:185179
decreased granulocyte monocyte progenitor cell number J:185179
decreased hemoglobin content J:185179
enlarged liver J:185179
enlarged spleen J:185179
hemolytic anemia J:185179
increased erythroblast number J:185179
increased hematopoietic stem cell number J:185179
increased mean corpuscular volume J:185179
increased megakaryocyte-erythroid progenitor cell number J:185179
intermingled spleen red and white pulp J:185179
pale kidney J:185179
pale liver J:185179
pallor J:185179
reticulocytosis J:185179
spherocytosis J:185179
thymus hypoplasia J:185179
Egln1tm2.1Fsl/Egln1tm2.1Fsl
Commd10Tg(Vav1-icre)A2Kio/Commd10+
B6.Cg-Egln1tm2.1Fsl Commd10Tg(Vav1-icre)A2Kio 		increased erythroid progenitor cell number J:202737
increased hematocrit J:202737
increased hemoglobin content J:202737
polycythemia J:202737
F8tm1.1Rmnt/F8tm1.1Rmnt
Commd10Tg(Vav1-icre)A2Kio/Commd10+
involves: 129 * C57BL/6 * C57BL/10 * CBA/Ca * SJL 		decreased circulating factor VIII level J:212401
Fbxo21em1Smbk/Fbxo21em1Smbk
Commd10Tg(Vav1-icre)A2Kio/Commd10+
B6.Cg-Fbxo21em1Smbk Commd10Tg(Vav1-icre)A2Kio 		abnormal bone marrow cell physiology J:333469
abnormal stress erythropoiesis J:333469
decreased spleen weight J:333469
increased granulocyte monocyte progenitor cell number J:333469
increased susceptibility to induced morbidity/mortality J:333469
increased T cell number J:333469
Gt(ROSA)26Sortm1(CAG-Etv2,-GFP)Hkata/Gt(ROSA)26Sor+
Commd10Tg(Vav1-icre)A2Kio/Commd10+
involves: C57BL/6NCrlj * C57BL/10 * CBA/Ca * CBA/JNCrlj 		abnormal bone marrow cell morphology/development J:203163
abnormal hematopoietic system morphology/development J:203163
anemia J:203163
decreased common myeloid progenitor cell number J:203163
decreased erythroid progenitor cell number J:203163
preweaning lethality, incomplete penetrance J:203163
Gt(ROSA)26Sortm1(CAG-PSTPIP1)Dtg/Gt(ROSA)26Sor+
Commd10Tg(Vav1-icre)A2Kio/Commd10+
involves: C57BL/6 * C57BL/10 * CBA/Ca 		no abnormal phenotype detected J:196002
Gt(ROSA)26Sortm2(CAG-PSTPIP1*)Dtg/Gt(ROSA)26Sor+
Commd10Tg(Vav1-icre)A2Kio/Commd10+
involves: C57BL/6 * C57BL/10 * CBA/Ca 		normal behavior/neurological phenotype J:196002
normal growth/size/body region phenotype J:196002
normal immune system phenotype J:196002
Idh1tm1Mak/Idh1tm1Mak
Commd10Tg(Vav1-icre)A2Kio/Commd10+
involves: 129P2/OlaHsd * C57BL/6 * C57BL/10 * CBA/Ca 		abnormal common lymphocyte progenitor cell morphology J:186700
abnormal common myeloid progenitor cell morphology J:186700
normal hematopoietic system phenotype J:186700
increased hematopoietic stem cell number J:186700
Idh1tm2Mak/Idh1tm2Mak
Commd10Tg(Vav1-icre)A2Kio/Commd10+
involves: C57BL/6 * C57BL/10 * CBA/Ca 		abnormal common lymphocyte progenitor cell morphology J:186700
abnormal common myeloid progenitor cell morphology J:186700
normal hematopoietic system phenotype J:186700
increased hematopoietic stem cell number J:186700
Ifngr1tm1.1Rds/Ifngr1tm1.1Rds
Commd10Tg(Vav1-icre)A2Kio/Commd10+
B6NTac.Cg-Ifngr1tm1.1Rds Commd10Tg(Vav1-icre)A2Kio 		increased susceptibility to bacterial infection J:206257
increased susceptibility to bacterial infection induced morbidity/mortality J:206257
Ikzf1tm1.1(Pax5)Mbu/Ikzf1+
Tcf3tm1Mbu/Tcf3tm1Mbu
Commd10Tg(Vav1-icre)A2Kio/Commd10+
involves: 129P2/OlaHsd * C57BL/10 * CBA/Ca 		abnormal immunoglobulin heavy chain V(D)J recombination J:137719
normal immune system phenotype J:137719
Il22tm1.1Lex/Il22tm1.1Lex
Commd10Tg(Vav1-icre)A2Kio/Commd10+
involves: 129S5/SvEvBrd * C57BL/6N * C57BL/10 * CBA/Ca 		decreased physiological sensitivity to xenobiotic J:305794
increased erythrocyte cell number J:305794
Il22tm1.1Lex/Il22tm1.1Lex
Riok2tm1c(KOMP)Wtsi/Riok2+
Commd10Tg(Vav1-icre)A2Kio/Commd10+
involves: 129S5/SvEvBrd * C57BL/6N * C57BL/10 * CBA/Ca 		decreased physiological sensitivity to xenobiotic J:305794
increased erythrocyte cell number J:305794
increased erythroid progenitor cell number J:305794
Il22ra1tm1.1Koll/Il22ra1tm1.1Koll
Riok2tm1c(KOMP)Wtsi/Riok2+
Commd10Tg(Vav1-icre)A2Kio/Commd10+
involves: C57BL/6N * C57BL/10 * CBA/Ca 		normal hematopoietic system phenotype J:305794
Jagn1tm1c(EUCOMM)Hmgu/Jagn1tm1c(EUCOMM)Hmgu
Commd10Tg(Vav1-icre)A2Kio/Commd10+
involves: C57BL/6N * C57BL/10 * CBA/Ca 		abnormal neutrophil morphology J:214828
abnormal neutrophil physiology J:214828
impaired neutrophil chemotaxis J:214828
impaired neutrophil recruitment J:214828
increased susceptibility to fungal infection J:214828
Jak2tm1.1Ble/Jak2+
Commd10Tg(Vav1-icre)A2Kio/Commd10+
involves: 129 * C57BL/6 * C57BL/10 * CBA/Ca 		abnormal blood coagulation J:257910
abnormal blood vessel morphology J:257910
abnormal cytokine level J:257910
abnormal erythrocyte morphology J:257910
abnormal thrombosis J:257910
enlarged spleen J:257910
extramedullary hematopoiesis J:257910
increased erythrocyte cell number J:257910
increased erythroid progenitor cell number J:257910
increased granulocyte number J:257910
increased heart rate J:257910
increased leukocyte cell number J:257910
increased megakaryocyte cell number J:257910
increased megakaryocyte progenitor cell number J:257910
increased neutrophil cell number J:257910
limb paralysis J:257910
premature death J:257910
reticulocytosis J:257910
tachypnea J:257910
thrombocytosis J:257910
Jak2tm1.2Ble/Jak2+
Picalmtm1.1Tmae/Picalm+
Commd10Tg(Vav1-icre)A2Kio/Commd10+
involves: 129S6/SvEvTac * C57BL/6 * C57BL/10 * CBA * SJL 		decreased mean corpuscular hemoglobin J:220728
decreased mean corpuscular volume J:220728
increased erythrocyte cell number J:220728
increased hematocrit J:220728
increased hemoglobin content J:220728
reticulocytosis J:220728
thrombocytosis J:220728
Jak2tm1.2Ble/Jak2+
Picalmtm1.1Tmae/Picalmtm1.1Tmae
Commd10Tg(Vav1-icre)A2Kio/Commd10+
involves: 129S6/SvEvTac * C57BL/6 * C57BL/10 * CBA * SJL 		abnormal iron homeostasis J:220728
decreased CD4-positive, alpha-beta T cell number J:220728
decreased CD8-positive, alpha-beta T cell number J:220728
decreased erythrocyte cell number J:220728
decreased hematocrit J:220728
decreased hemoglobin content J:220728
decreased mean corpuscular hemoglobin J:220728
decreased mean corpuscular volume J:220728
hypochromic microcytic anemia J:220728
reticulocytosis J:220728
Kdm1atm1.1Sho/Kdm1atm1.1Sho
Commd10Tg(Vav1-icre)A2Kio/Commd10+
involves: 129 * C57BL/6 * C57BL/10 * CBA/Ca 		abnormal definitive hematopoiesis J:201572
decreased body size J:201572
decreased bone marrow cell number J:201572
decreased common myeloid progenitor cell number J:201572
decreased erythrocyte cell number J:201572
decreased hematopoietic stem cell number J:201572
decreased leukocyte cell number J:201572
postnatal lethality, incomplete penetrance J:201572
thrombocytopenia J:201572
Kitltm2.1Sjm/Kitltm2.2Sjm
Commd10Tg(Vav1-icre)A2Kio/Commd10+
involves: BALB/cJ * C57BL * CBA/Ca * SJL 		decreased hematopoietic cell number J:180431
normal hematopoietic system phenotype J:180431
Kmt2atm1Brad/Kmt2atm1Brad
Commd10Tg(Vav1-icre)A2Kio/?
involves: 129S4/SvJae * C57BL/6 * C57BL/10 * CBA/Ca 		abnormal bone marrow cell physiology J:149811
decreased common myeloid progenitor cell number J:149811
decreased pre-B cell number J:149811
Kmt5btm1Jnw/Kmt5btm1Jnw
Kmt5ctm1.1Jnw/Kmt5ctm1.1Jnw
Commd10Tg(Vav1-icre)A2Kio/Commd10+
involves: 129/Sv * C57BL/6J * C57BL/10 * CBA/Ca 		abnormal class switch recombination J:139510
abnormal lymphopoiesis J:139510
decreased B cell number J:139510
decreased double-positive T cell number J:139510
normal immune system phenotype J:139510
Lmo4tm1Slp/Lmo4tm1Slp
Commd10Tg(Vav1-icre)A2Kio/Commd10+
involves: 129S1/Sv * C57BL/6 * C57BL/10 * CBA/Ca 		abnormal acute inflammation J:282740
abnormal gut-associated lymphoid tissue morphology J:282740
abnormal lymphocyte physiology J:282740
abnormal lymphopoiesis J:282740
decreased Peyer's patch number J:282740
increased susceptibility to bacterial infection J:282740
Lmo4tm1Slp/Lmo4tm1Slp
Yeats4em1Zfa/Yeats4em1Zfa
Commd10Tg(Vav1-icre)A2Kio/Commd10+
involves: 129S1/Sv * C57BL/6 * C57BL/10 * CBA/Ca 		abnormal acute inflammation J:282740
abnormal lymphocyte physiology J:282740
abnormal lymphopoiesis J:282740
increased susceptibility to bacterial infection J:282740
Ly6etm1c(EUCOMM)Hmgu/Ly6etm1c(EUCOMM)Hmgu
Commd10Tg(Vav1-icre)A2Kio/Commd10+
B6.Cg-Ly6etm1c(EUCOMM)Hmgu Commd10Tg(Vav1-icre)A2Kio 		abnormal liver morphology J:291868
abnormal mononuclear cell morphology J:291868
decreased B cell number J:291868
decreased CD4-positive, alpha-beta T cell number J:291868
decreased dendritic cell number J:291868
decreased inflammatory response J:291868
decreased macrophage cell number J:291868
decreased neutrophil cell number J:291868
decreased NK cell number J:291868
hepatic necrosis J:291868
increased circulating alanine transaminase level J:291868
increased susceptibility to Coronaviridae infection J:291868
increased susceptibility to Coronaviridae infection induced morbidity/mortality J:291868
pale liver J:291868
Myd88tm1Defr/Myd88tm1Defr
Commd10Tg(Vav1-icre)A2Kio/Commd10+
involves: 129P2/OlaHsd * C57BL/6 * SJL 		abnormal NK cell physiology J:139001
Patz1tm1.2Welm/Patz1tm1.2Welm
Commd10Tg(Vav1-icre)A2Kio/Commd10+
B6.Cg-Patz1tm1.2Welm Commd10Tg(Vav1-icre)A2Kio 		abnormal mast cell differentiation J:209168
decreased interleukin-6 secretion J:209168
normal immune system phenotype J:209168
Picalmtm1.1Tmae/Picalmtm1.1Tmae
Commd10Tg(Vav1-icre)A2Kio/Commd10+
involves: 129S6/SvEvTac * C57BL/6 * C57BL/10 * CBA * SJL 		abnormal iron homeostasis J:220728
decreased CD4-positive, alpha-beta T cell number J:220728
decreased CD8-positive, alpha-beta T cell number J:220728
decreased erythrocyte cell number J:220728
decreased mean corpuscular hemoglobin J:220728
decreased mean corpuscular volume J:220728
increased circulating erythropoietin level J:220728
microcytic anemia J:220728
reticulocytosis J:220728
Piezo1tm2.1Apat/Piezo1tm2.1Apat
Commd10Tg(Vav1-icre)A2Kio/Commd10+
involves: C57BL/6 * C57BL/10 * CBA 		abnormal calcium ion homeostasis J:229436
abnormal erythrocyte ion transport J:229436
abnormal spleen morphology J:229436
abnormal splenic cell ratio J:229436
decreased blood osmolality J:229436
decreased circulating haptoglobin level J:229436
decreased erythrocyte cell number J:229436
decreased hematocrit J:229436
decreased mean corpuscular hemoglobin concentration J:229436
increased erythrocyte osmotic fragility J:229436
increased mean corpuscular hemoglobin J:229436
increased mean corpuscular volume J:229436
increased red blood cell distribution width J:229436
macrocytosis J:229436
Pkn3tm1.1Mrl/Pkn3tm1.1Mrl
Commd10Tg(Vav1-icre)A2Kio/Commd10+
B6.Cg-Pkn3tm1.1Mrl Commd10Tg(Vav1-icre)A2Kio 		normal hematopoietic system phenotype J:216983
Plek2tm1Pji/Plek2tm1Pji
Jak2tm1.1Ble/Jak2+
Commd10Tg(Vav1-icre)A2Kio/Commd10+
involves: 129 * C57BL/6 * C57BL/10 * CBA/Ca 		abnormal cell differentiation J:257910
abnormal granulocyte differentiation J:257910
abnormal megakaryocyte differentiation J:257910
extramedullary hematopoiesis J:257910
normal hematopoietic system phenotype J:257910
normal homeostasis/metabolism phenotype J:257910
normal immune system phenotype J:257910
premature death J:257910
Rbpjtm1Hon/Rbpjtm1Hon
Commd10Tg(Vav1-icre)A2Kio/Commd10+
involves: 129P2/OlaHsd * C57BL/10 * CBA/Ca 		decreased tumor growth/size J:162770
Rc3h1tm1.1Mass/Rc3h1tm1.1Mass
Commd10Tg(Vav1-icre)A2Kio/Commd10+
involves: C57BL/6 * C57BL/10 * CBA/Ca * NZB * SJL 		abnormal B cell differentiation J:177784
abnormal effector T cell morphology J:177784
abnormal germinal center B cell physiology J:177784
abnormal spleen B cell follicle morphology J:177784
decreased B cell number J:177784
decreased bone marrow cell number J:177784
decreased IgA level J:177784
decreased IgG1 level J:177784
decreased IgG3 level J:177784
decreased immature B cell number J:177784
enlarged spleen J:177784
normal immune system phenotype J:177784
increased eosinophil cell number J:177784
increased IgG2b level J:177784
increased macrophage cell number J:177784
increased regulatory T cell number J:177784
increased spleen weight J:177784
increased splenocyte number J:177784
spleen hyperplasia J:177784
Rfx7tm1.1Ggaur/Rfx7tm1.1Ggaur
Commd10Tg(Vav1-icre)A2Kio/Commd10+
involves: C57BL/6 * C57BL/10 * CBA/Ca 		abnormal NK cell morphology J:282535
decreased NK cell number J:282535
small spleen J:282535
Rfx7tm1.1Ggaur/Rfx7tm1.1Ggaur
Rptortm1.1Dmsa/Rptor+
Commd10Tg(Vav1-icre)A2Kio/Commd10+
involves: 129S/SvEv * C57BL/10 * CBA/Ca 		abnormal NK cell morphology J:282535
decreased NK cell number J:282535
small spleen J:282535
Riok2tm1c(KOMP)Wtsi/Riok2+
Commd10Tg(Vav1-icre)A2Kio/Commd10+
involves: C57BL/6N * C57BL/10 * CBA/Ca 		abnormal bone marrow cell physiology J:305794
abnormal CD4-positive, alpha beta T cell morphology J:305794
abnormal CD4-positive, alpha-beta T cell physiology J:305794
abnormal circulating interleukin level J:305794
abnormal erythropoiesis J:305794
abnormal hematopoietic system physiology J:305794
abnormal immune system morphology J:305794
abnormal interleukin secretion J:305794
anemia J:305794
decreased erythrocyte cell number J:305794
decreased erythroid progenitor cell number J:305794
decreased hematocrit J:305794
decreased hemoglobin content J:305794
decreased neutrophil cell number J:305794
increased granulocyte monocyte progenitor cell number J:305794
increased hematopoietic stem cell number J:305794
increased monocyte cell number J:305794
increased myeloid cell number J:305794
increased NK T cell number J:305794
increased physiological sensitivity to xenobiotic J:305794
increased susceptibility to xenobiotic induced morbidity/mortality J:305794
Riok2tm1c(KOMP)Wtsi/Riok2tm1c(KOMP)Wtsi
Commd10Tg(Vav1-icre)A2Kio/Commd10+
involves: C57BL/6N * C57BL/10 * CBA/Ca 		prenatal lethality, complete penetrance J:305794
Rr7tm3.1Kio/Rr7+
Commd10Tg(Vav1-icre)A2Kio/Commd10+
involves: 129S4/SvJae * C57BL/6 * C57BL/10 * CBA/Ca 		normal immune system phenotype J:179326
Satb1tm2Kos/Satb1tm2Kos
Commd10Tg(Vav1-icre)A2Kio/Commd10+
involves: C57BL/6 * C57BL/10 * CBA/Ca 		abnormal renal glomerulus morphology J:252606
absent regulatory T cells J:252606
decreased salivation J:252606
increased anti-nuclear antigen antibody level J:252606
increased autoantibody level J:252606
increased susceptibility to autoimmune disorder J:252606
increased urine protein level J:252606
kidney inflammation J:252606
pancreas inflammation J:252606
premature death J:252606
salivary gland degeneration J:252606
salivary gland inflammation J:252606
Snai1tm1.1Stjw/Snai1tm1.1Stjw
Commd10Tg(Vav1-icre)A2Kio/Commd10+
B6.Cg-Snai1tm1.1Stjw Commd10Tg(Vav1-icre)A2Kio 		no abnormal phenotype detected J:214991
Sppl3tm1Itl/Sppl3tm1Itl
Commd10Tg(Vav1-icre)A2Kio/Commd10+
involves: 129S/SvEv * C57BL/6 * C57BL/10 * CBA/Ca 		abnormal NK cell differentiation J:280182
decreased mature NK cell number J:280182
decreased NK cell number J:280182
normal hematopoietic system phenotype J:280182
normal immune system phenotype J:280182
impaired natural killer cell mediated cytotoxicity J:280182
increased immature NK cell number J:280182
normal mortality/aging J:280182
Syktm1.1Nns/Syktm1.1Nns
Commd10Tg(Vav1-icre)A2Kio/Commd10+
involves: C57BL/10 * CBA/Ca 		abnormal blood vessel morphology J:181715
abnormal lymphatic vessel morphology J:181715
edema J:181715
normal mortality/aging J:181715
Syktm1.1Nns/Syktm1.1Nns
Tg(Tie1-cre)9Ref/0
Commd10Tg(Vav1-icre)A2Kio/Commd10+
involves: 129S1/Sv * 129X1/SvJ * C57BL/10 * CBA/Ca 		abnormal lymphatic vessel morphology J:181715
normal mortality/aging J:181715
Tcf3tm1Mbu/Tcf3tm1Mbu
Commd10Tg(Vav1-icre)A2Kio/Commd10+
involves: 129P2/OlaHsd * C57BL/10 * CBA/Ca 		decreased pro-B cell number J:137719
Tcf3tm1Mbu/Tcf3tm1Mbu
Tg(Ikzf1-Tcfe2a,-GFP)1Mbu/0
Commd10Tg(Vav1-icre)A2Kio/Commd10+
involves: 129P2/OlaHsd * C57BL * CBA 		normal immune system phenotype J:137719
Tg(JAK2*V617F)FF1Rsko/0
Commd10Tg(Vav1-icre)A2Kio/Commd10+
involves: C57BL/6 * C57BL/10 * CBA/Ca 		abnormal bone marrow morphology J:134364
abnormal common myeloid progenitor cell morphology J:134364
abnormal erythropoiesis J:134364
abnormal megakaryocyte progenitor cell morphology J:134364
abnormal myelopoiesis J:134364
abnormal spleen morphology J:134364
decreased B cell number J:134364
decreased hemoglobin content J:134364
decreased T cell number J:134364
enlarged spleen J:134364
extramedullary hematopoiesis J:134364
increased bone marrow cell number J:134364
increased erythroid progenitor cell number J:134364
increased megakaryocyte cell number J:134364
increased neutrophil cell number J:134364
myelofibrosis J:134364
spleen fibrosis J:134364
thrombocytosis J:134364
Tg(Kit*D814V)1Roer/0
Commd10Tg(Vav1-icre)A2Kio/Commd10+
involves: C57BL/6 * C57BL/10 * CBA/Ca 		neonatal lethality J:169611
Tg(Kit*D814V)3Roer/0
Commd10Tg(Vav1-icre)A2Kio/Commd10+
involves: C57BL/6 * C57BL/10 * CBA/Ca 		neonatal lethality J:169611
Trp53tm1Tyj/Trp53tm1Tyj
Commd10Tg(Vav1-icre)A2Kio/Commd10+
involves: 129S2/SvPas * C57BL/6N * C57BL/10 * CBA/Ca 		abnormal interleukin secretion J:305794
Trp53tm1Tyj/Trp53tm1Tyj
Riok2tm1c(KOMP)Wtsi/Riok2+
Commd10Tg(Vav1-icre)A2Kio/Commd10+
involves: 129S2/SvPas * C57BL/6N * C57BL/10 * CBA/Ca 		normal immune system phenotype J:305794
Yeats4em1Zfa/Yeats4em1Zfa
Commd10Tg(Vav1-icre)A2Kio/Commd10+
involves: C57BL/6 * C57BL/10 * CBA/Ca 		abnormal acute inflammation J:282740
abnormal gut-associated lymphoid tissue morphology J:282740
abnormal interleukin secretion J:282740
abnormal lymphocyte physiology J:282740
abnormal lymphopoiesis J:282740
decreased interferon-gamma secretion J:282740
decreased interleukin-5 secretion J:282740
decreased interleukin-12 secretion J:282740
decreased lymphocyte cell number J:282740
decreased Peyer's patch number J:282740
increased susceptibility to bacterial infection J:282740
Zbtb17tm1Cksn/Zbtb17tm1Cksn
Commd10Tg(Vav1-icre)A2Kio/Commd10+
B6.Cg-Zbtb17tm1Cksn Commd10Tg(Vav1-icre)A2Kio 		arrested T cell differentiation J:170508
decreased DN1 thymic pro-T cell number J:170508
decreased DN2 thymocyte number J:170508
decreased DN3 thymocyte number J:170508
decreased double-negative T cell number J:170508
decreased gamma-delta T cell number J:170508
decreased T cell number J:170508
decreased thymocyte number J:170508
increased T cell apoptosis J:170508
thymus hypoplasia J:170508
Zbtb38em1Dbhat/Zbtb38em1Dbhat
Commd10Tg(Vav1-icre)A2Kio/Commd10+
involves: C57BL/6J * C57BL/6N * C57BL/10 * CBA/Ca 		normal immune system phenotype J:296556
Zfp318tm1.1Jhws/Zfp318tm1.1Jhws
Commd10Tg(Vav1-icre)A2Kio/Commd10+
B6.Cg-Zfp318tm1.1Jhws TgVav1-creA2Kio 		decreased IgD level J:215815
decreased transitional stage T2 B cell number J:215815
increased IgM level J:215815
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11/12/2024
MGI 6.24 		The Jackson Laboratory