Hopx Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Hopx
HOP homeobox
MGI:1916782

41 phenotypes from 4 alleles in 4 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Hopx^tm1.1Joe/Hopx^tm1.1Joe involves: 129S1/Sv * 129X1/SvJ * C57BL/6	abnormal frontal plane axis	J:108531
	abnormal lung development	J:121211
	abnormal lung-associated mesenchyme development	J:121211
	abnormal myocardium layer morphology	J:79153
	abnormal type II pneumocyte morphology	J:121211
	decreased tidal volume	J:121211
	embryonic lethality during organogenesis, incomplete penetrance	J:79153
	impaired lung alveolus development	J:121211
	increased surfactant secretion	J:121211
	intraventricular block	J:108531
	lung hemorrhage	J:121211
	neonatal lethality, incomplete penetrance	J:121211
	pericardial effusion	J:79153
	postnatal lethality, incomplete penetrance	J:121211
	prolonged HV interval	J:108531
	prolonged P wave	J:108531
	prolonged QRS complex duration	J:108531
	prolonged QT interval	J:108531
	thick lung-associated mesenchyme	J:121211
	thin myocardium	J:79153
	thin myocardium compact layer	J:79153
Hopx^tm1.1Joe/Hopx^tm1.1Joe involves: 129S6/SvEvTac	abnormal myocardium layer morphology	J:121995
	embryonic lethality during organogenesis, incomplete penetrance	J:121995
	increased myocardial fiber number	J:121995
Hopx^tm1Eno/Hopx^tm1Eno involves: 129S6/SvEvTac	abnormal cardiovascular system physiology	J:79152
	abnormal fetal cardiomyocyte proliferation	J:79152
	abnormal muscle physiology	J:79152
	cardiac fibrosis	J:79152
	cardiac hypertrophy	J:79152
	decreased cardiac muscle contractility	J:79152
	embryonic growth arrest	J:79152
	embryonic lethality during organogenesis, incomplete penetrance	J:79152
	enlarged heart	J:79152
	heart hyperplasia	J:79152
	hemopericardium	J:79152
	increased heart weight	J:79152
	thick ventricular wall	J:79152
	thin myocardium	J:79152
Hopx^{tm2.1(cre/ERT2)Joe}/Hopx⁺ involves: 129 * C57BL/6	normal digestive/alimentary phenotype	J:285672
Tg(Myh6-Hod)3Joe/? Not Specified	abnormal heart ventricle morphology	J:121995
	abnormal systemic arterial blood pressure	J:121995
	cardiac fibrosis	J:121995
	cardiac hypertrophy	J:121677, J:121995
	congestive heart failure	J:121995
	enlarged heart	J:121995
	increased left ventricle diastolic pressure	J:121995
	increased myocardial fiber size	J:121995
	premature death	J:121995
	thick ventricular wall	J:121995

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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