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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Afg3l2
AFG3-like AAA ATPase 2
MGI:1916847
22 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background		 Annotated Term Reference
Afg3l1tm1.1Arte/Afg3l1tm1.1Arte
Afg3l2tm1Arte/Afg3l2tm1Arte
Gt(ROSA)26Sortm1Lrsn/Gt(ROSA)26Sor+
Tg(Plp1-cre/ERT)3Pop/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * C57BL/6N 		abnormal dermal layer morphology J:237410
abnormal melanoblast morphology J:237410
abnormal mitochondrial physiology J:237410
abnormal oligodendrocyte morphology J:237410
abnormal oligodendrocyte physiology J:237410
abnormal Schwann cell morphology J:237410
abnormal sciatic nerve morphology J:237410
decreased melanocyte number J:237410
demyelination J:237410
dilated mitochondrion J:237410
Afg3l1tm1.1Arte/Afg3l1tm1.1Arte
Afg3l2tm1Arte/Afg3l2tm1Arte
Tg(Plp1-cre/ERT)3Pop/0
involves: C57BL/6J * C57BL/6N 		abnormal brain white matter morphology J:237410
abnormal coat/hair pigmentation J:237410
abnormal spinal cord white matter morphology J:237410
astrocytosis J:237410
axon degeneration J:237410
decreased body fat mass J:237410
decreased body weight J:237410
demyelination J:237410
impaired coordination J:237410
microgliosis J:237410
Afg3l2tm1Arte/Afg3l2tm1Arte
Gt(ROSA)26Sortm1Lrsn/Gt(ROSA)26Sor+
Tg(Pcp2-cre)2Mpin/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		abnormal nervous system electrophysiology J:193564
abnormal Purkinje cell mitochondrial morphology J:193564
Afg3l2tm1Arte/Afg3l2tm1Arte
Gt(ROSA)26Sortm1Lrsn/Gt(ROSA)26Sor+
Tg(Plp1-cre/ERT)3Pop/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J 		abnormal mitochondrial shape J:237410
dilated mitochondrion J:237410
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory