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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Arhgef12
Rho guanine nucleotide exchange factor 12
MGI:1916882
13 phenotypes from 4 alleles in 4 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Arhgef12tm1.1Wet/Arhgef12tm1.1Wet
Tg(Lck-cre)548Jxm/0
involves: 129 * C57BL/6 * CBA 		abnormal T cell proliferation J:149560
Arhgef12tm1b(KOMP)Wtsi/Arhgef12+
C57BL/6N-Arhgef12tm1b(KOMP)Wtsi/Tcp 		abnormal embryo size J:211773
abnormal heart morphology J:211773
abnormal heart shape J:211773
decreased locomotor activity J:211773
embryonic growth retardation J:211773
enlarged heart J:211773
increased prepulse inhibition J:211773
Arhgef12tm1b(KOMP)Wtsi/Arhgef12tm1b(KOMP)Wtsi
C57BL/6N-Arhgef12tm1b(KOMP)Wtsi/Tcp 		abnormal embryo size J:211773
embryonic growth retardation J:211773
preweaning lethality, incomplete penetrance J:211773
Arhgef12tm1Sgkd/Arhgef12tm1Sgkd
involves: 129 * C57BL/6J 		prenatal lethality, incomplete penetrance J:198274
Arhgef12tm1Soff/Arhgef12tm1Soff
Not Specified 		normal cardiovascular system phenotype J:141641
decreased systemic arterial blood pressure J:141641
decreased vasoconstriction J:141641
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory