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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Card11
caspase recruitment domain family, member 11
MGI:1916978
98 phenotypes from 18 alleles in 17 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Card11em1(IMPC)Ccpcz/Card11em1(IMPC)Ccpcz
C57BL/6NCrl-Card11em1(IMPC)Ccpcz/Ccpcz 		abnormal spleen morphology J:211773
abnormal testis morphology J:211773
abnormal thymus morphology J:211773
abnormal uterus morphology J:211773
decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number J:211773
decreased circulating alkaline phosphatase level J:211773
decreased effector memory CD8-positive, alpha-beta T cell number J:211773
decreased effector memory T-helper cell number J:211773
decreased spleen weight J:211773
enlarged thymus J:211773
hydrometra J:211773
increased CD4-positive, alpha-beta T cell number J:211773
increased CD8-positive, alpha-beta T cell number J:211773
increased CD8-positive, naive alpha-beta T cell number J:211773
increased freezing behavior J:211773
increased leukocyte cell number J:211773
increased lymphocyte cell number J:211773
increased T cell number J:211773
increased T-helper cell number J:211773
small spleen J:211773
small testis J:211773
Card11em1Welu/Card11+
involves: C57BL/6 		decreased marginal zone B cell number J:292926
decreased transitional stage T1 B cell number J:292926
decreased transitional stage T3 B cell number J:292926
impaired humoral immune response J:292926
increased transitional stage T2 B cell number J:292926
Card11em1Welu/Card11em1Welu
involves: C57BL/6 		abnormal B cell differentiation J:292926
abnormal germinal center B cell morphology J:292926
abnormal plasma cell differentiation J:292926
decreased B cell proliferation J:292926
decreased B-1 B cell number J:292926
decreased B-1a cell number J:292926
decreased germinal center B cell number J:292926
decreased IgG level J:292926
decreased IgM level J:292926
decreased marginal zone B cell number J:292926
decreased pre-B cell number J:292926
decreased transitional stage T1 B cell number J:292926
decreased transitional stage T3 B cell number J:292926
impaired humoral immune response J:292926
increased follicular B cell number J:292926
increased transitional stage T2 B cell number J:292926
Card11em2Welu/Card11+
involves: C57BL/6 		increased B-1 B cell number J:292926
increased marginal zone B cell number J:292926
Card11em2Welu/Card11em2Welu
involves: C57BL/6 		abnormal plasma cell differentiation J:292926
decreased mature B cell number J:292926
enlarged spleen J:292926
increased B cell proliferation J:292926
increased B-1a cell number J:292926
increased B-1b cell number J:292926
increased germinal center B cell number J:292926
increased marginal zone B cell number J:292926
increased pre-B cell number J:292926
increased transitional stage T2 B cell number J:292926
Card11em3Welu/Card11em3Welu
Not Specified 		decreased B-1 B cell number J:292926
decreased marginal zone B cell number J:292926
Card11m1Btlr/Card11m1Btlr
C57BL/6J-Card11m1Btlr 		abnormal CD4-positive, CD25-positive, alpha-beta regulatory T cell morphology J:149767
abnormal cytokine secretion J:149767
abnormal cytotoxic T cell physiology J:139069
abnormal double-negative T cell morphology J:139069, J:149767
abnormal NK cell physiology J:139069
abnormal T cell activation J:139069
decreased B cell proliferation J:139069, J:149767
decreased B-1 B cell number J:139069, J:149767
decreased gamma-delta T cell number J:139069, J:149767
decreased IgG1 level J:139069, J:149767
decreased IgG2a level J:139069, J:149767
decreased IgG2b level J:139069, J:149767
decreased IgG2c level J:149767
decreased IgG3 level J:139069, J:149767
decreased IgM level J:139069, J:149767
decreased immunoglobulin level J:139069
decreased interferon-gamma secretion J:139069
decreased interleukin-2 secretion J:139069
decreased mature B cell number J:139069, J:149767
decreased memory T cell number J:139069, J:149767
decreased NK cell number J:139069, J:149767
decreased NK T cell number J:139069, J:149767
decreased regulatory T cell number J:149767
decreased T cell proliferation J:139069, J:149767
dermatitis J:139069, J:149767
normal immune system phenotype J:139069
Card11M2Btlr/Card11M2Btlr
involves: C57BL/6J 		decreased IgM level J:198555
Card11m3Btlr/Card11m3Btlr
C57BL/6J-Card11m3Btlr 		increased B-1a cell number J:221487
Card11M4Btlr/Card11+
C57BL/6J-Card11M4Btlr 		decreased B-1a cell number J:254856
increased B-1b cell number J:254856
Card11M4Btlr/Card11M4Btlr
C57BL/6J-Card11M4Btlr 		decreased B-1a cell number J:254856
decreased IgM level J:254856
impaired humoral immune response J:254856
increased B-1b cell number J:254856
Card11M5Btlr/Card11+
C57BL/6J-Card11M5Btlr 		decreased IgM level J:254879
impaired humoral immune response J:254879
increased B-1 B cell number J:254879
increased B-1a cell number J:254879
Card11M5Btlr/Card11M5Btlr
C57BL/6J-Card11M5Btlr 		decreased IgM level J:254879
impaired humoral immune response J:254879
increased B-1 B cell number J:254879
increased B-1a cell number J:254879
Card11M6Btlr/Card11M6Btlr
C57BL/6J-Card11M6Btlr 		increased alpha-beta T cell number J:272116
Card11M7Btlr/Card11M7Btlr
C57BL/6J-Card11M7Btlr 		abnormal T cell differentiation J:274762
decreased B cell number J:274762
decreased B-1 B cell number J:274762
decreased central memory CD4-positive, alpha-beta T cell number J:274762
decreased effector memory CD4-positive, alpha-beta T cell number J:274762
decreased effector memory CD8-positive, alpha-beta T cell number J:274762
increased CD4-positive, alpha-beta T cell number J:274762
increased CD8-positive, alpha-beta T cell number J:274762
increased T cell number J:274762
Card11m8Btlr/Card11m8Btlr
C57BL/6J-Card11m8Btlr 		abnormal B cell differentiation J:274940
decreased B cell number J:274940
decreased B-1a cell number J:274940
decreased effector memory CD8-positive, alpha-beta T cell number J:274940
decreased IgG level J:274940
decreased IgM level J:274940
decreased response to antigen J:274940
impaired humoral immune response J:274940
increased B-1b cell number J:274940
increased CD4-positive, alpha-beta T cell number J:274940
increased CD8-positive, alpha-beta T cell number J:274940
increased NK T cell number J:274940
increased T cell number J:274940
Card11tm1.1Litt/Card11tm1.1Litt
Tnfrsf4tm2(cre)Nik/Tnfrsf4+
involves: 129P2/OlaHsd * 129X1/SvJ 		abnormal T cell activation J:180410
normal immune system phenotype J:180410
respiratory system inflammation J:180410
normal respiratory system phenotype J:180410
Card11tm1Litt/Card11tm1Litt
involves: 129P2/OlaHsd 		abnormal B cell proliferation J:89322
abnormal double-negative T cell morphology J:89322
abnormal T cell activation J:89322
abnormal T cell differentiation J:89322
abnormal T cell proliferation J:89322
absent B-1a cells J:89322
decreased IgA level J:89322
decreased IgG1 level J:89322
decreased IgG2b level J:89322
decreased IgG3 level J:89322
decreased IgM level J:89322
decreased immunoglobulin level J:89322
Card11tm1Pngr/Card11tm1Pngr
involves: 129P2/OlaHsd 		abnormal B cell differentiation J:84036
abnormal B cell physiology J:84036
abnormal interleukin-2 secretion J:84036
abnormal lymphocyte morphology J:84036
abnormal T cell activation J:84036
absent B-1a cells J:84036
decreased B cell proliferation J:84036
decreased IgA level J:84036
decreased IgE level J:84036
decreased IgG1 level J:84036
decreased IgG2a level J:84036
decreased IgG2b level J:84036
decreased IgG3 level J:84036
decreased IgG level J:84036
decreased IgM level J:84036
decreased immunoglobulin level J:84036
decreased NK cell number J:84036
Card11tm1Pngr/Card11tm1Pngr
involves: 129P2/OlaHsd * C57BL/6 		normal immune system phenotype J:122394
Card11tm1Vmd/Card11+
involves: 129S6/SvEvTac * C57BL/6N 		decreased B cell proliferation J:95800
Card11tm1Vmd/Card11tm1Vmd
involves: 129S6/SvEvTac * C57BL/6N 		abnormal B cell physiology J:95800
absent immature B cells J:95800
decreased B cell proliferation J:95800
decreased IgA level J:95800
decreased IgG1 level J:95800
decreased IgG2a level J:95800
decreased IgG2b level J:95800
decreased IgG3 level J:95800
decreased IgG level J:95800
decreased IgM level J:95800
decreased T cell proliferation J:95800
Card11tm1Xav/Card11tm1Xav
involves: 129 * C57BL/6 		abnormal T cell activation J:132226
abnormal T-helper 2 cell differentiation J:132226
decreased airway responsiveness J:132226
decreased circulating interleukin-4 level J:132226
decreased circulating interleukin-5 level J:132226
decreased IgE level J:132226
increased CD4-positive, alpha-beta T cell number J:132226
increased CD8-positive, alpha-beta T cell number J:132226
lung inflammation J:132226
Card11unm/Card11unm
C57BL/6JSfdAnu-Card11unm/Anu 		abnormal B cell differentiation J:84042
abnormal immune system physiology J:84042
abnormal T cell activation J:84042
decreased B-1 B cell number J:84042
decreased IgG3 level J:84042
decreased IgM level J:84042
decreased immunoglobulin level J:84042
dermatitis J:84042
erythroderma J:84042
increased IgE level J:84042
increased immunoglobulin level J:84042
increased inflammatory response J:84042
lymph node hyperplasia J:84042
spleen hyperplasia J:84042
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11/12/2024
MGI 6.24 		The Jackson Laboratory