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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Fbxo7
F-box protein 7
MGI:1917004
53 phenotypes from 4 alleles in 3 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Fbxo7tm1a(EUCOMM)Hmgu/Fbxo7tm1a(EUCOMM)Hmgu
involves: C57BL/6N 		abnormal proerythroblast morphology J:183053
decreased erythroblast number J:183053
increased erythroid progenitor cell number J:183053
increased pro-B cell number J:183053
Fbxo7tm1a(EUCOMM)Wtsi/Fbxo7tm1a(EUCOMM)Wtsi
C57BL/6N-Fbxo7tm1a(EUCOMM)Wtsi/Wtsi 		decreased circulating fructosamine level J:211773
decreased circulating iron level J:211773
decreased erythrocyte cell number J:211773
decreased hematocrit J:211773
decreased hemoglobin content J:211773
decreased leukocyte cell number J:211773
increased circulating bilirubin level J:211773
increased circulating sodium level J:211773
increased mean corpuscular hemoglobin J:211773
increased red blood cell distribution width J:211773
male infertility J:211773
thrombocytosis J:211773
Fbxo7tm1a(EUCOMM)Wtsi/Fbxo7tm1a(EUCOMM)Wtsi
involves: C57BL/6N 		abnormal effector T cell number J:272313
abnormal reticulocyte cell number J:272313
abnormal spermatogenesis J:272313
abnormal T cell differentiation J:272313
anemia J:272313
anisocytosis J:272313
arrest of spermiogenesis J:272313
normal behavior/neurological phenotype J:272313
decreased CD4-positive, alpha-beta T cell number J:272313
decreased CD8-positive, alpha-beta T cell number J:272313
decreased circulating iron level J:272313
decreased erythrocyte cell number J:272313
decreased hematocrit J:272313
decreased hemoglobin content J:272313
decreased T cell number J:272313
decreased testis weight J:272313
enlarged spleen J:272313
extramedullary hematopoiesis J:272313
hyperchromic macrocytic anemia J:272313
immotile sperm J:272313
increased activated T cell number J:272313
increased circulating bilirubin level J:272313
increased double-negative T cell number J:272313
increased effector memory CD4-positive, alpha-beta T cell number J:272313
increased effector memory CD8-positive, alpha-beta T cell number J:272313
increased erythroblast number J:272313
increased erythrocyte clearance J:272313
increased mean corpuscular hemoglobin concentration J:272313
increased mean corpuscular volume J:272313
increased memory T cell number J:272313
increased red blood cell distribution width J:272313
increased spleen weight J:272313
increased susceptibility to bacterial infection J:272313
increased susceptibility to bacterial infection induced morbidity/mortality J:272313
male infertility J:272313
normal mortality/aging J:272313
oligozoospermia J:272313
reticulocytosis J:272313
teratozoospermia J:272313
thymus atrophy J:272313
thymus hypoplasia J:272313
Fbxo7tm1b(EUCOMM)Wtsi/Fbxo7tm1b(EUCOMM)Wtsi
involves: C57BL/6N 		postnatal lethality, complete penetrance J:272313
Fbxo7tm1c(EUCOMM)Wtsi/Fbxo7tm1c(EUCOMM)Wtsi
Tg(Cd4-cre)1Cwi/0
involves: C57BL/6J * C57BL/6N 		decreased CD8-positive, alpha-beta T cell number J:272313
decreased T cell number J:272313
normal hematopoietic system phenotype J:272313
normal immune system phenotype J:272313
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory