A1cf Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

A1cf
APOBEC1 complementation factor
MGI:1917115

28 phenotypes from 4 alleles in 5 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
A1cf^{Tg(Myh6-cre/Esr1)1Jmk}/A1cf⁺ involves: 129S/Sv C57BL/6 * FVB/N	abnormal myocardium layer morphology	J:164749
	decreased cardiac muscle contractility	J:164749
	dilated cardiomyopathy	J:164749
A1cf^{Tg(Myh6-cre/Esr1)1Jmk}/A1cf^{Tg(Myh6-cre/Esr1)1Jmk} B6.FVB(129)-A1cf^{Tg(Myh6-cre/Esr1*)1Jmk}/J	normal mortality/aging	J:231727
A1cf^{tm1b(EUCOMM)Hmgu}/A1cf^{tm1b(EUCOMM)Hmgu} B6N(Cg)-A1cf^{tm1b(EUCOMM)Hmgu}/J	increased circulating sodium level	J:211773
	increased grip strength	J:211773
	increased heart weight	J:211773
	increased mean corpuscular hemoglobin	J:211773
A1cf^{tm1c(EUCOMM)Hmgu}/A1cf^{tm1c(EUCOMM)Hmgu} Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺ involves: C57BL/6N * DBA	abnormal blood homeostasis	J:281365
	abnormal hepatobiliary system physiology	J:281365
	abnormal urine homeostasis	J:281365
	decreased circulating glucose level	J:281365
	decreased circulating insulin level	J:281365
	decreased circulating ketone body level	J:281365
	decreased fasting circulating glucose level	J:281365
	decreased liver triglyceride level	J:281365
	decreased liver weight	J:281365
	decreased susceptibility to diet-induced obesity	J:281365
	decreased urine uric acid level	J:281365
	normal homeostasis/metabolism phenotype	J:281365
	impaired gluconeogenesis	J:281365
	improved glucose tolerance	J:281365
	increased circulating cholesterol level	J:281365
	increased circulating triglyceride level	J:281365
	increased insulin sensitivity	J:281365
	increased liver glycogen level	J:281365
A1cf^tm1Ddsn/A1cf^tm1Ddsn involves: 129X1/SvJ	decreased cell proliferation	J:114732
A1cf^tm1Ddsn/A1cf^tm1Ddsn involves: 129X1/SvJ	embryonic lethality before implantation, complete penetrance	J:114732

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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