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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		A1cf
APOBEC1 complementation factor
MGI:1917115
139 phenotypes from multigenic genotypes
Export: Excel File
Allelic Composition
Genetic Background		 Annotated Term Reference
A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
Ppiftm1Jmol/Ppiftm1Jmol
Slc8b1tm1c(EUCOMM)Wtsi/Slc8b1tm1c(EUCOMM)Wtsi
involves: 129S4/SvJaeSor * C57BL/6N * FVB/N 		abnormal sarcomere morphology J:325413
cardiac hypertrophy J:325413
decreased heart ventricle muscle contractility J:325413
A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
Tg(CAG-DMPK*)1323Coop/0
involves: FVB 		abnormal cardiac muscle relaxation J:127391
abnormal cardiovascular system physiology J:127391
abnormal myocardial fiber morphology J:127391
atrioventricular block J:127391
cardiac interstitial fibrosis J:127391
decreased cardiac muscle contractility J:127391
decreased diastolic filling velocity J:127391
decreased heart left ventricle wall thickness J:127391
dilated cardiomyopathy J:127391
dilated heart left ventricle J:127391
increased myocardial fiber size J:127391
irregular heartbeat J:127391
premature death J:127391
prolonged PR interval J:127391
prolonged QRS complex duration J:127391
A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
Prdm16tm1.1Brsp/Prdm16tm1.1Brsp
B6.Cg-Prdm16tm1.1Brsp A1cfTg(Myh6-cre/Esr1*)1Jmk 		normal cardiovascular system phenotype J:326525
A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
Tg(Myh6-2A)#Know/0
involves: BALB/c * C57BL/6 * FVB/N 		abnormal heart echocardiography feature J:128060
abnormal intercalated disk morphology J:128060
abnormal myocardial fiber morphology J:128060
abnormal sarcolemma morphology J:128060
abnormal sarcomere morphology J:128060
abnormal Z line morphology J:128060
ascites J:128060
cardiac interstitial fibrosis J:128060
decreased heart left ventricle muscle contractility J:128060
dilated cardiomyopathy J:128060
heart inflammation J:128060
increased heart atrium size J:128060
increased heart ventricle size J:128060
pleural effusion J:128060
A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
Tg(CAG-cat,-Dusp14)4Lyg/0
involves: C57BL/6J * FVB/N 		cardiac fibrosis J:263251
decreased cardiac muscle contractility J:263251
decreased response of heart to induced stress J:263251
enlarged heart J:263251
increased heart weight J:263251
increased lung weight J:263251
increased myocardial fiber size J:263251
myocardium hypertrophy J:263251
A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
Ak2em1.1Dze/Ak2em1.1Dze
involves: 129 * C57BL/6 * FVB/N 		abnormal heart echocardiography feature J:305579
abnormal metabolism J:305579
decreased heart left ventricle muscle contractility J:305579
dilated heart ventricle J:305579
A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
Clk4em1Yihc/Clk4em1Yihc
B6(FVB)-Clk4em1Yihc A1cfTg(Myh6-cre/Esr1*)1Jmk 		abnormal sarcomere morphology J:327369
cardiac interstitial fibrosis J:327369
congestive heart failure J:327369
decreased heart ventricle muscle contractility J:327369
diffuse Z line J:327369
increased heart left ventricle size J:327369
increased heart weight J:327369
increased lung weight J:327369
increased myocardial fiber size J:327369
myocardium hypertrophy J:327369
A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
Sdhaf4em1Bcgen/Sdhaf4em1Bcgen
B6.Cg-Sdhaf4em1Bcgen A1cfTg(Myh6-cre/Esr1*)1Jmk 		enlarged heart J:345348
premature death J:345348
A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
Dusp12em1Zhzy/Dusp12em1Zhzy
involves: FVB/N 		cardiac fibrosis J:345360
cardiomyopathy J:345360
decreased cardiac muscle contractility J:345360
dilated heart ventricle J:345360
increased cellular sensitivity to oxidative stress J:345360
insulin resistance J:345360
myocardium hypertrophy J:345360
A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
Pakaptm1.1Div/Pakaptm1.1Div
involves: C57BL/6 * FVB/N 		abnormal response to cardiac infarction J:345193
increased myocardial infarct size J:345193
increased response of heart to induced stress J:345193
increased susceptibility to myocardial ischemic injury J:345193
A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
Tg(CAG-cat,-Tcf25)1Xdgz/0
involves: C57BL/6J * FVB/N 		decreased response of heart to induced stress J:317382
A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Tg(CAG-cat,-Trim8)4Holi/0
involves: C57BL/6J * FVB/N 		cardiovascular system phenotype J:303651
growth/size/body region phenotype J:303651
increased susceptibility to induced morbidity/mortality J:303651
mortality/aging J:303651
reproductive system phenotype J:303651
Abcb8tm1Hard/Abcb8tm1Hard
A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
involves: FVB 		abnormal cardiac muscle relaxation J:182234
abnormal cardiovascular system physiology J:182234
abnormal heart morphology J:182234
abnormal myocardial fiber morphology J:182234
cardiac fibrosis J:182234
cardiomyopathy J:182234
decreased cardiac muscle contractility J:182234
decreased cardiac output J:182234
decreased left ventricle systolic pressure J:182234
increased heart iron level J:182234
increased heart left ventricle size J:182234
increased heart weight J:182234
Akap6tm1.1Mskf/Akap6tm1.1Mskf
A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
involves: C57BL/6 * FVB/N * SJL 		abnormal heart ventricles weight J:214288
cardiac interstitial fibrosis J:214288
decreased heart rate J:214288
heart left ventricle hypertrophy J:214288
increased cardiomyocyte apoptosis J:214288
increased heart left atrium weight J:214288
increased heart left ventricle wall thickness J:214288
increased heart left ventricle weight J:214288
increased myocardial fiber size J:214288
Atg5tm1Myok/Atg5tm1Myok
A1cfTg(Myh6-cre/Esr1*)1Jmk/?
involves: 129S/SvEv * FVB/N 		abnormal cardiac muscle contractility J:121778
abnormal myocardial fiber physiology J:121778
dilated heart left ventricle J:121778
increased heart weight J:121778
increased lung weight J:121778
increased myocardial fiber size J:121778
Atg7tm1Tchi/Atg7tm1Tchi
Cnot3tm1.1Kjkb/Cnot3tm1.1Kjkb
A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
involves: 129P2/OlaHsd * C57BL/6NCrlj * CBA/JNCrlj * FVB/N 		decreased cardiac muscle contractility J:260012
premature death J:260012
Atg7tm1Tchi/Atg7tm1Tchi
Cnot3tm1.1Kjkb/Cnot3tm1.1Kjkb
A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cfTg(Myh6-cre/Esr1*)1Jmk
involves: 129P2/OlaHsd * C57BL/6NCrlj * CBA/JNCrlj * FVB/N 		decreased cardiac muscle contractility J:260012
Atp2a2tm1.1Iemr/Atp2a2tm1.1Iemr
A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
involves: 129P2/OlaHsd * C57BL/6J * FVB/N 		abnormal cardiovascular system physiology J:157143
abnormal heart left atrium morphology J:157143
abnormal heart left ventricle pressure J:157143
abnormal myocardial fiber physiology J:157143
normal cardiovascular system phenotype J:157143
decreased cardiac muscle contractility J:157143
decreased cardiac output J:157143
decreased heart rate J:157143
decreased systemic arterial systolic blood pressure J:157143
dilated heart atrium J:157143
enlarged heart J:157143
increased circulating noradrenaline level J:157143
Cacna1ctm1Ggm/Cacna1ctm1Ggm
A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
involves: 129S1/Sv * 129X1/SvJ * FVB/N 		decreased cardiac muscle contractility J:189406
dilated heart ventricle J:189406
premature death J:189406
Cacna1ctm3Hfm/Cacna1ctm4Hfm
A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N 		abnormal muscle electrophysiology J:175463
premature death J:175463
Cd36tm2.1Mfe/Cd36tm2.1Mfe
A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
B6.Cg-Cd36tm2.1Mfe A1cfTg(Myh6-cre/Esr1*)1Jmk 		abnormal glucose homeostasis J:225392
abnormal response to cardiac infarction J:225392
normal cardiovascular system phenotype J:225392
decreased cardiac muscle triglyceride level J:225392
decreased fatty acid oxidation J:225392
decreased fatty acids level J:225392
Cdh2tm1Glr/Cdh2Gt(OST49160)Lex
A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
involves: 129S5/SvEvBrd * 129S6/SvEvTac * C57BL/6J * FVB/N 		abnormal cardiovascular system morphology J:98828
abnormal cardiovascular system physiology J:98828
abnormal heart shape J:98828
abnormal impulse conducting system conduction J:98828
abnormal intercalated disk morphology J:98828
abnormal myocardial fiber morphology J:98828
decreased cardiac output J:98828
decreased heart left ventricle muscle contractility J:98828
decreased heart rate J:98828
dilated heart atrium J:98828
dilated heart left ventricle J:98828
dilated heart right ventricle J:98828
increased heart rate J:98828
irregular heartbeat J:98828
premature death J:98828
Cdh2tm1Glr/Cdh2tm1Hyn
A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
involves: 129S6/SvEvTac * C57BL/6J * FVB/N 		abnormal cardiovascular system morphology J:98828
abnormal cardiovascular system physiology J:98828
abnormal heart shape J:98828
abnormal impulse conducting system conduction J:98828
abnormal intercalated disk morphology J:98828
abnormal myocardial fiber morphology J:98828
decreased cardiac output J:98828
decreased heart left ventricle muscle contractility J:98828
decreased heart rate J:98828
dilated heart atrium J:98828
dilated heart left ventricle J:98828
dilated heart right ventricle J:98828
increased heart rate J:98828
irregular heartbeat J:98828
premature death J:98828
Cnot3tm1.1Kjkb/Cnot3tm1.1Kjkb
A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
involves: 129P2/OlaHsd * C57BL/6 * FVB/N 		congestive heart failure J:260012
premature death J:260012
Ctnna1tm1Efu/Ctnna1tm1Efu
A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
involves: 129X1/SvJ * FVB/N 		dilated cardiomyopathy J:197814
Cxadrtm1Mgot/Cxadrtm1Mgot
A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
involves: FVB 		abnormal atrioventricular node conduction J:140109
abnormal atrioventricular node morphology J:140109
increased heart rate variability J:140109
prolonged PR interval J:140109
Dmdtm1.1Know/Dmdtm1.1Know
A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
Tg(Myh6-2A)#Know/0
involves: BALB/c * C3H * C57BL/6 * FVB/N 		abnormal heart echocardiography feature J:207775
cardiac fibrosis J:207775
cardiomyopathy J:207775
decreased susceptibility to injury J:207775
increased cardiac muscle contractility J:207775
Eif4ebp1tm1Nso/Eif4ebp1tm1Nso
Mtortm1.1Gcon/Mtortm1.1Gcon
A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
involves: 129S4/SvJae * C57BL/6 * FVB/N 		abnormal autophagy J:163763
abnormal mitochondrial physiology J:163763
cardiac interstitial fibrosis J:163763
normal cardiovascular system phenotype J:163763
decreased cardiomyocyte apoptosis J:163763
premature death J:163763
Gt(ROSA)26Sorem1(Tbc1d15)Jren/Gt(ROSA)26Sorem1(Tbc1d15)Jren
A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
involves: C57BL/6N * FVB/N 		abnormal mitochondrial physiology J:341775
decreased myocardial infarct size J:341775
decreased susceptibility to myocardial ischemic injury J:341775
Gt(ROSA)26Sortm1(CAG-Nr2f2)Tsa/Gt(ROSA)26Sor+
A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
involves: 129S1/Sv * 129X1/SvJ * FVB/N 		abnormal cardiovascular system physiology J:227012
abnormal cell physiology J:227012
abnormal mitochondrial inner membrane morphology J:227012
abnormal mitochondrial physiology J:227012
abnormal mitochondrial shape J:227012
abnormal oxidative phosphorylation J:227012
abnormal respiratory electron transport chain J:227012
decreased cardiac muscle contractility J:227012
decreased fatty acid oxidation J:227012
decreased oxygen consumption J:227012
dilated cardiomyopathy J:227012
enlarged heart J:227012
premature death J:227012
Gt(ROSA)26Sortm1.1(CAG-Mirc20)Eem/Gt(ROSA)26Sor+
A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
involves: 129 * C57BL/6 * FVB/N 		abnormal myocardial fiber morphology J:233994
abnormal myocardial fiber physiology J:233994
abnormal response to cardiac infarction J:233994
decreased cardiomyocyte apoptosis J:233994
decreased myocardial fiber size J:233994
increased heart weight J:233994
increased myocardial fiber number J:233994
Hcn4tm1.1Ggc/Hcn4tm1.1Ggc
A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
involves: 129S/SvEv * C57BL/6 * FVB/N 		abnormal impulse conducting system conduction J:168248
abnormal sinoatrial node conduction J:168248
atrioventricular block J:168248
decreased heart rate J:168248
premature death J:168248
prolonged PQ interval J:168248
Hif1atm1Stom/Hif1atm1Stom
A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
involves: FVB/N 		abnormal cardiovascular system physiology J:120332
abnormal heart size J:120332
decreased angiogenesis J:120332
Hspd1tm1c(EUCOMM)Hmgu/Hspd1tm1c(EUCOMM)Hmgu
A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
involves: Black Swiss * C57BL/6 * C57BL/6N * FVB/N 		abnormal cardiovascular system physiology J:283049
abnormal heart echocardiography feature J:283049
abnormal heart ventricles weight J:283049
abnormal mitochondrial physiology J:283049
cardiac fibrosis J:283049
congestive heart failure J:283049
decreased heart left ventricle muscle contractility J:283049
dilated cardiomyopathy J:283049
dilated heart ventricle J:283049
enlarged heart J:283049
increased lung weight J:283049
oxidative stress J:283049
premature death J:283049
thin ventricular wall J:283049
Irx3tm3Hui/Irx3tm3Hui
Irx5tm3Hui/Irx5tm3Hui
A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
involves: FVB 		prolonged PR interval J:189007
prolonged QRS complex duration J:189007
Juptm1.1Glr/Juptm1.1Glr
A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
involves: 129S6/SvEvTac * C57BL/6 * FVB/N * SJL 		abnormal cardiovascular system physiology J:170618
abnormal heart right ventricle morphology J:170618
abnormal intercalated disk morphology J:170618
abnormal interleukin level J:170618
abnormal myocardial fiber morphology J:170618
abnormal sarcomere morphology J:170618
cardiac fibrosis J:170618
normal cardiovascular system phenotype J:170618
decreased heart left ventricle muscle contractility J:170618
diffuse Z line J:170618
dilated heart left ventricle J:170618
heart inflammation J:170618
heart left ventricle hypertrophy J:170618
increased heart left ventricle size J:170618
increased heart right ventricle size J:170618
increased heart weight J:170618
increased myocardial fiber size J:170618
premature death J:170618
pulmonary edema J:170618
Ldb3tm4Chen/Ldb3tm4Chen
A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
involves: 129S1/Sv * 129X1/SvJ * Black Swiss * FVB/N 		abnormal cardiovascular system physiology J:144739
dilated cardiomyopathy J:144739
dilated heart left ventricle J:144739
dilated heart right ventricle J:144739
enlarged heart J:144739
premature death J:144739
Mcattm1.1Ssmi/Mcattm1.1Ssmi
A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
involves: 129P2/OlaHsd * C57BL/6 * FVB/N 		no abnormal phenotype detected J:192213
Mcutm1.1Jmol/Mcutm1.1Jmol
A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6J * FVB/N 		abnormal myocardial fiber morphology J:224853
abnormal myocardial fiber physiology J:224853
normal cardiovascular system phenotype J:224853
decreased aerobic running capacity J:224853
decreased cardiomyocyte apoptosis J:224853
decreased heart ventricle muscle contractility J:224853
decreased myocardial infarct size J:224853
Mcur1tm1c(KOMP)Wtsi/Mcur1tm1c(KOMP)Wtsi
A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
involves: 129S4/SvJaeSor * C57BL/6N * FVB/N 		abnormal mitochondrial physiology J:235756
decreased body size J:235756
postnatal lethality, incomplete penetrance J:235756
Med1tm2Jkr/Med1tm2Jkr
A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
involves: 129P2/OlaHsd * FVB/N 		abnormal heart echocardiography feature J:243730
abnormal heart morphology J:243730
cardiac interstitial fibrosis J:243730
congestive heart failure J:243730
decreased cardiac muscle contractility J:243730
dilated cardiomyopathy J:243730
dilated heart ventricle J:243730
enlarged heart J:243730
increased cardiomyocyte apoptosis J:243730
premature death J:243730
thin ventricular wall J:243730
Mtortm1.1Gcon/Mtortm1.1Gcon
A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N 		abnormal autophagy J:163763
abnormal mitochondrial physiology J:163763
abnormal myocardial fiber morphology J:163763
abnormal myocardial fiber physiology J:163763
abnormal sarcomere morphology J:163763
abnormal translation J:163763
ascites J:163763
cardiac interstitial fibrosis J:163763
congestive heart failure J:163763
decreased cardiac muscle contractility J:163763
decreased heart left ventricle wall thickness J:163763
decreased heart ventricle muscle contractility J:163763
decreased myocardial fiber size J:163763
dilated cardiomyopathy J:163763
dilated mitochondrion J:163763
enlarged heart J:163763
increased cardiomyocyte apoptosis J:163763
increased heart atrium size J:163763
increased heart ventricle size J:163763
increased response of heart to induced stress J:163763
pleural effusion J:163763
premature death J:163763
thin interventricular septum J:163763
Mybpc3tm2.1Rmos/Mybpc3tm2.1Rmos
A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
involves: 129 * C57BL/6 * FVB/N 		abnormal heart left ventricle morphology J:202199
cardiac fibrosis J:202199
cardiac interstitial fibrosis J:202199
normal cardiovascular system phenotype J:202199
decreased heart ventricle muscle contractility J:202199
increased myocardial fiber size J:202199
increased response of heart to induced stress J:202199
myocardial fiber disarray J:202199
Myocdtm1Msp/Myocdtm1Msp
A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
involves: 129/Sv * C57BL/6J * FVB/N 		abnormal intercalated disk morphology J:154666
abnormal myocardial fiber morphology J:154666
abnormal sarcomere morphology J:154666
cardiac fibrosis J:154666
decreased cardiac muscle contractility J:154666
dilated cardiomyopathy J:154666
enlarged heart J:154666
increased cardiomyocyte apoptosis J:154666
myocardial fiber degeneration J:154666
myocardial fiber disarray J:154666
pericardial effusion J:154666
premature death J:154666
Pik3catm1.1Rzl/Pik3catm1.1Rzl
A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
involves: 129S4/SvJaeSor * C57BL/6 * FVB/N 		abnormal myocardial fiber physiology J:166421
decreased cardiac muscle contractility J:166421
decreased heart weight J:166421
increased heart left ventricle size J:166421
thick ventricular wall J:166421
Pik3cbtm1.1Rzl/Pik3cbtm1.1Rzl
A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
involves: 129S4/SvJaeSor * C57BL/6 * FVB/N 		normal cardiovascular system phenotype J:166421
decreased heart weight J:166421
Plce1tm2Avsm/Plce1tm2Avsm
A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
involves: 129S6/SvEvTac * C57BL/6 * FVB/N 		decreased response of heart to induced stress J:197247
Ppp1r12bem1Chana/Ppp1r12bem1Chana
A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
involves: C57BL/6J * FVB/N 		abnormal myocardial fiber morphology J:346986
normal cardiovascular system phenotype J:346986
decreased response of heart to induced stress J:346986
Ptentm1Hwu/Ptentm1Hwu
A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
involves: 129S4/SvJae * FVB/N 		abnormal response to cardiac infarction J:149180
decreased myocardial infarct size J:149180
Ptgs2tm1Gaf/Ptgs2tm1Gaf
A1cfTg(Myh6-cre/Esr1*)1Jmk/?
involves: 129/Sv * C57BL/6 * FVB/N 		decreased heart left ventricle muscle contractility J:148331
decreased heart rate J:148331
dilated heart left ventricle J:148331
impaired exercise endurance J:148331
increased myocardial fiber size J:148331
ventricular tachycardia J:148331
weight loss J:148331
Rtf1tm1c(KOMP)Wtsi/Rtf1tm1c(KOMP)Wtsi
A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
involves: C57BL/6N * FVB/N 		abnormal heart echocardiography feature J:338311
abnormal intercalated disk morphology J:338311
cardiac fibrosis J:338311
congestive heart failure J:338311
decreased heart left ventricle muscle contractility J:338311
decreased heart left ventricle wall thickness J:338311
decreased heart right ventricle wall thickness J:338311
decreased heart ventricle muscle contractility J:338311
dilated cardiomyopathy J:338311
dilated heart left ventricle J:338311
dilated heart right ventricle J:338311
dilated heart ventricle J:338311
myocardial fiber disarray J:338311
premature death J:338311
thin ventricular wall J:338311
Ryr2tm1Krbr/Ryr2tm1Krbr
A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N 		abnormal atrial thrombosis J:210083
abnormal sinus arrhythmia J:210083
abnormal T wave J:210083
atrioventricular block J:210083
cardiomyopathy J:210083
congestive heart failure J:210083
decreased cardiac output J:210083
decreased heart rate J:210083
increased heart rate J:210083
lethargy J:210083
premature death J:210083
sinus bradycardia J:210083
Ryr2tm1Krbr/Ryr2tm3.1Swch
A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
involves: 129S1/Sv * 129X1/SvJ * FVB/N 		decreased heart rate J:215190
premature death J:215190
Senp2tm1.1Eyeh/Senp2tm1.1Eyeh
A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
involves: FVB/N 		normal mortality/aging J:217910
normal nervous system phenotype J:217910
Slc8b1tm1c(EUCOMM)Wtsi/Slc8b1tm1c(EUCOMM)Wtsi
A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
involves: 129S4/SvJaeSor * C57BL/6N * FVB/N 		abnormal sarcomere morphology J:325413
cardiac fibrosis J:325413
cardiac hypertrophy J:325413
congestive heart failure J:325413
decreased heart left ventricle muscle contractility J:325413
decreased heart rate J:325413
dilated heart left ventricle J:325413
dilated mitochondrion J:325413
increased heart weight J:325413
increased myocardial fiber size J:325413
irregular heartbeat J:325413
premature death J:325413
prolonged PR interval J:325413
prolonged QRS complex duration J:325413
Slc25a3tm1.1Jmol/Slc25a3tm1.1Jmol
A1cfTg(Myh6-cre/Esr1*)1Jmk/?
involves: 129S6/SvEvTac * C57BL/6 * FVB/N 		abnormal calcium ion homeostasis J:229795
abnormal cardiac muscle tissue morphology J:229795
abnormal channel response J:229795
abnormal mitochondrial ATP synthesis coupled electron transport J:229795
abnormal sarcomere morphology J:229795
cardiac hypertrophy J:229795
cardiomyopathy J:229795
decreased heart left ventricle muscle contractility J:229795
increased heart weight J:229795
increased mitochondrial fission J:229795
Srftm1Zli/Srftm1Zli
A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
involves: 129 * C57BL/6J * FVB/N 		abnormal cardiac muscle relaxation J:135043
abnormal intercalated disk morphology J:135043
abnormal myocardial fiber morphology J:135043
abnormal myocardium layer morphology J:135043
abnormal Z line morphology J:135043
cardiac fibrosis J:135043
cardiac hypertrophy J:135043
congestive heart failure J:135043
decreased heart left ventricle muscle contractility J:135043
dilated cardiomyopathy J:135043
dilated heart ventricle J:135043
increased heart left ventricle size J:135043
premature death J:135043
Tbc1d15em1Jren/Tbc1d15em1Jren
A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
involves: C57BL/6N * FVB/N 		abnormal intracellular organelle morphology J:341775
abnormal mitochondrial physiology J:341775
increased myocardial infarct size J:341775
increased susceptibility to myocardial ischemic injury J:341775
Tgfbr1tm1.1Karl/Tgfbr1tm1.1Karl
A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
involves: 129S/Sv * C57BL/6 * FVB/N 		normal cardiovascular system phenotype J:164749
decreased cardiac muscle contractility J:164749
dilated cardiomyopathy J:164749
premature death J:164749
Tgfbr2tm1.2Hlm/Tgfbr2tm1.2Hlm
A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
involves: 129S6/SvEvTac * C57BL/6 * FVB/N 		normal cardiovascular system phenotype J:164749
decreased cardiac muscle contractility J:164749
dilated cardiomyopathy J:164749
premature death J:164749
Tnni3ktm1Tfo/Tnni3ktm1Tfo
A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
involves: C57BL/6 * FVB/N 		abnormal myocardial fiber physiology J:213546
abnormal response to cardiac infarction J:213546
normal cardiovascular system phenotype J:213546
decreased myocardial infarct size J:213546
Tnni3ktm1Tfo/Tnni3ktm1Tfo
A1cfTg(Myh6-cre/Esr1*)1Jmk/?
involves: C57BL/6 * FVB/N 		increased myocardial fiber number J:249318
Tspotm1.1Maf/Tspotm1.1Maf
A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
involves: C57BL/6 * FVB/N 		normal cardiovascular system phenotype J:214129
Txniptm1Rlee/Txniptm1Rlee
A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
involves: 129S4/SvJae * FVB/N 		abnormal response of heart to induced stress J:141487
increased cardiac muscle cell glucose uptake J:141487
Wdr1tm1.1Zzy/Wdr1tm1.1Zzy
A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
involves: 129S6/SvEvTac * C57BL/6J 		abnormal myocardial fiber morphology J:211364
cardiac hypertrophy J:211364
increased heart weight J:211364
increased myocardial fiber size J:211364
premature death J:211364
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
06/12/2024
MGI 6.13 		The Jackson Laboratory