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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Fars2
phenylalanine-tRNA synthetase 2, mitochondrial
MGI:1917205
18 phenotypes from 4 alleles in 3 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Fars2em1(IMPC)J/Fars2+
C57BL/6NJ-Fars2em1(IMPC)J/Mmjax 		decreased grip strength J:211773
increased circulating aspartate transaminase level J:211773
Fars2em1(IMPC)J/Fars2em1(IMPC)J
C57BL/6NJ-Fars2em1(IMPC)J/Mmjax 		preweaning lethality, complete penetrance J:211773
Fars2em1Chenk/Fars2em1Chenk
involves: C57BL/6J 		abnormal ectoderm development J:339244
embryonic growth arrest J:339244
embryonic lethality between implantation and somite formation, complete penetrance J:339244
Fars2em2Chenk/Fars2em2Chenk
involves: C57BL/6J 		abnormal ectoderm development J:339244
embryonic growth arrest J:339244
embryonic lethality between implantation and somite formation, complete penetrance J:339244
Fars2em3Chenk/Fars2em3Chenk
Tg(Nes-cre)1Kln/0
involves: C57BL/6 * C57BL/6J * SJL 		abnormal cell morphology J:339244
abnormal cerebral cortex morphology J:339244
abnormal mitochondrial crista morphology J:339244
abnormal mitochondrial physiology J:339244
abnormal oxidative phosphorylation J:339244
decreased brain weight J:339244
decreased cellular ATP level J:339244
enlarged brain ventricles J:339244
increased apoptosis J:339244
loss of cortex neurons J:339244
neonatal lethality, complete penetrance J:339244
thin cerebral cortex J:339244
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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12/10/2024
MGI 6.24 		The Jackson Laboratory