Ace2 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Ace2
angiotensin converting enzyme 2
MGI:1917258

83 phenotypes from 11 alleles in 17 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Ace2^{em1(ACE2)Yowa}/Ace2^{em1(ACE2)Yowa} C57BL/6-Ace2^{em1(ACE2)Yowa}	abnormal circulating cytokine level	J:288243
	abnormal pulmonary alveolus epithelial cell morphology	J:288243
	increased circulating interferon-gamma level	J:288243
	increased circulating interleukin-9 level	J:288243
	increased susceptibility to Coronaviridae infection	J:288243
	interstitial pneumonia	J:288243
	lung hemorrhage	J:288243
	thick pulmonary interalveolar septum	J:288243
Ace2^{em1(IMPC)Ccpcz}/Y C57BL/6NCrl-Ace2^{em1(IMPC)Ccpcz}/Ccpcz	abnormal heart morphology	J:211773
	abnormal spleen morphology	J:211773
	enlarged heart	J:211773
	enlarged spleen	J:211773
Ace2^{em1(IMPC)Ccpcz}/Ace2^{em1(IMPC)Ccpcz} C57BL/6NCrl-Ace2^{em1(IMPC)Ccpcz}/Ccpcz	abnormal lens morphology	J:211773
	abnormal retina morphology	J:211773
	abnormal spleen morphology	J:211773
	abnormal thymus morphology	J:211773
	abnormal uterus morphology	J:211773
	decreased lean body mass	J:211773
	enlarged spleen	J:211773
	enlarged thymus	J:211773
	hydrometra	J:211773
	increased total body fat amount	J:211773
Ace2^em1Cya/Y C57BL/6J-Ace2^em1Cya/Cya	abnormal feces composition	J:299383
	abnormal intestine morphology	J:299383
	abnormal intestine physiology	J:299383
	decreased colon length	J:299383
	impaired intestine regeneration	J:299383
	increased susceptibility to induced colitis	J:299383
	increased susceptibility to weight loss	J:299383
	intestinal edema	J:299383
	intestinal inflammation	J:299383
	melena	J:299383
	oxidative stress	J:299383
Ace2^em1Shyy/Ace2^em1Shyy B6.Cg-Ace2^em1Shyy	pulmonary hypertension	J:286356
Ace2^em2Shyy/Ace2^em2Shyy B6.Cg-Ace2^em2Shyy	decreased pulmonary artery pressure	J:286356
Ace2^em#Yngh/Y involves: Kunming	decreased colon length	J:221616
	diarrhea	J:221616
	increased susceptibility to induced colitis	J:221616
	increased susceptibility to weight loss	J:221616
Ace2^{tm1a(KOMP)Wtsi}/Ace2^{tm1a(KOMP)Wtsi} Tg(FOXJ1-cre)F26Htzm/0 involves: C57BL/6N * C57BL/6NTac	increased neutrophil cell number	J:282139
	increased susceptibility to bacterial infection	J:282139
	increased susceptibility to bacterial infection induced morbidity/mortality	J:282139
	increased susceptibility to weight loss	J:282139
	lung inflammation	J:282139
Ace2^{tm1a(KOMP)Wtsi}/Y Tg(FOXJ1-cre)F26Htzm/0 involves: C57BL/6N * C57BL/6NTac	increased neutrophil cell number	J:282139
	increased susceptibility to bacterial infection	J:282139
	increased susceptibility to bacterial infection induced morbidity/mortality	J:282139
	increased susceptibility to weight loss	J:282139
	lung inflammation	J:282139
Ace2^tm1Cof/Y 129S6/SvEvTac-Ace2^tm1Cof	normal cardiovascular system phenotype	J:113108
	hypertension	J:113108
	increased angiotensin II level	J:113108
	increased circulating angiotensin II level	J:113108
Ace2^tm1Cof/Y B6.129S6-Ace2^tm1Cof	increased systemic arterial systolic blood pressure	J:113108
Ace2^tm1Cof/Y involves: 129S6/SvEvTac * C57BL/6J	decreased heart rate	J:113108
Ace2^tm1Cof/Y involves: 129S6/SvEvTac * C57BL/6J	increased systemic arterial systolic blood pressure	J:113108
Ace2^tm1Cof/Ace2^tm1Cof involves: 129S6/SvEvTac * C57BL/6	abnormal cornea epithelium morphology	J:289503
	abnormal cornea wound healing	J:289503
	cornea opacity	J:289503
	cornea vascularization	J:289503
	increased incidence of corneal inflammation	J:289503
Ace2^tm1Hira/Y involves: 129S7/SvEvBrd * C57BL/6	cardiac fibrosis	J:135766
	cardiac interstitial fibrosis	J:135766
	congestive heart failure	J:135766
	decreased heart ventricle muscle contractility	J:135766
	dilated heart left ventricle	J:135766
	increased angiotensin II level	J:135766
	increased circulating angiotensin II level	J:135766
	increased heart weight	J:135766
	increased lung weight	J:135766
	increased susceptibility to induced morbidity/mortality	J:135766
	pulmonary vascular congestion	J:135766
Ace2^tm1Lex/Y B6;129S5-Ace2^tm1Lex/Mmucd	yellow coat color	J:171883
Ace2^tm1Lex/Ace2^tm1Lex B6;129S5-Ace2^tm1Lex/Mmucd	abnormal enzyme/coenzyme activity	J:264991
	increased angiotensin I-converting enzyme activity	J:264991
	increased pulmonary respiratory rate	J:264991
	lung inflammation	J:264991
	yellow coat color	J:171883
Ace2^tm1Pngr/Y B6.129P2-Ace2^tm1Pngr/J	normal cardiovascular system phenotype	J:124548
Ace2^tm1Pngr/Y B6.129P2-Ace2^tm1Pngr/J	decreased susceptibility to Coronaviridae infection	J:286299
Ace2^tm1Pngr/Y involves: 129P2/OlaHsd	abnormal susceptibility to injury induced morbidity/mortality	J:100334
	increased angiotensin II level	J:100334
	increased circulating angiotensin II level	J:100334
	increased lung elastance	J:100334
	increased neutrophil cell number	J:282139
	increased susceptibility to bacterial infection	J:282139
	increased susceptibility to bacterial infection induced morbidity/mortality	J:282139
	increased susceptibility to injury	J:100334
	increased susceptibility to pulmonary hyaline membrane formation	J:100334
	increased susceptibility to weight loss	J:282139
	increased vascular permeability	J:100334
	lung inflammation	J:100334, J:282139
	pulmonary edema	J:100334
Ace2^tm1Pngr/Y involves: 129P2/OlaHsd * C57BL/6	abnormal cardiovascular system physiology	J:124548
	abnormal cytokine level	J:124548
	abnormal heart echocardiography feature	J:124548
	cardiac hypertrophy	J:124548
	congestive heart failure	J:124548
	decreased cardiac muscle contractility	J:77232, J:124548
	decreased heart left ventricle wall thickness	J:77232
	dilated cardiomyopathy	J:124548
	dilated heart left ventricle	J:124548
	dilated heart ventricle	J:124548
	heart inflammation	J:124548
	hypotension	J:77232
	increased left ventricle diastolic pressure	J:124548
	increased NAD(P)H oxidase activity	J:124548
	oxidative stress	J:124548
Ace2^tm1Pngr/Y involves: 129P2/OlaHsd * C57BL/6J	increased susceptibility to Orthomyxoviridae infection	J:277074
	increased susceptibility to Orthomyxoviridae infection induced morbidity/mortality	J:277074
	increased susceptibility to pulmonary hyaline membrane formation	J:277074
	lung inflammation	J:277074
	pulmonary edema	J:277074
Ace2^tm1Pngr/Ace2^tm1Pngr B6.129P2-Ace2^tm1Pngr/J	decreased susceptibility to Coronaviridae infection	J:286299
Ace2^tm1Pngr/Ace2^tm1Pngr involves: 129P2/OlaHsd	abnormal susceptibility to injury induced morbidity/mortality	J:100334
	increased angiotensin II level	J:100334
	increased circulating angiotensin II level	J:100334
	increased lung elastance	J:100334
	increased neutrophil cell number	J:282139
	increased susceptibility to bacterial infection	J:282139
	increased susceptibility to bacterial infection induced morbidity/mortality	J:282139
	increased susceptibility to injury	J:100334
	increased susceptibility to pulmonary hyaline membrane formation	J:100334
	increased susceptibility to weight loss	J:282139
	increased vascular permeability	J:100334
	lung inflammation	J:100334, J:282139
	pulmonary edema	J:100334
Ace2^tm1Pngr/Ace2^tm1Pngr involves: 129P2/OlaHsd * C57BL/6	decreased cardiac muscle contractility	J:77232
Ace2^tm1Pngr/Ace2^tm1Pngr involves: 129P2/OlaHsd * C57BL/6J	increased susceptibility to Orthomyxoviridae infection	J:277074
	increased susceptibility to Orthomyxoviridae infection induced morbidity/mortality	J:277074
	increased susceptibility to pulmonary hyaline membrane formation	J:277074
	lung inflammation	J:277074
	pulmonary edema	J:277074

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