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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Med23
mediator complex subunit 23
MGI:1917458
60 phenotypes from 6 alleles in 6 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Med23em1(IMPC)Wtsi/Med23+
C57BL/6N-Med23em1(IMPC)Wtsi/Wtsi 		decreased bone mineral content J:211773
decreased circulating fructosamine level J:211773
increased circulating HDL cholesterol level J:211773
increased lean body mass J:211773
increased red blood cell distribution width J:211773
Med23em1(IMPC)Wtsi/Med23em1(IMPC)Wtsi
C57BL/6N-Med23em1(IMPC)Wtsi/Wtsi 		abnormal chorion morphology J:261316
abnormal placenta morphology J:261316
abnormal trophoblast giant cell morphology J:261316
abnormal trophoblast layer morphology J:261316
lethality throughout fetal growth and development, complete penetrance J:261316
preweaning lethality, complete penetrance J:211773
Med23snouty/Med23snouty
involves: 129S1/Sv * C57BL/6 * FVB/NJ 		abnormal blood vessel morphology J:171522
abnormal nervous system development J:171522
abnormal trigeminal ganglion morphology J:171522
absent second pharyngeal arch J:171522
decreased embryo size J:171522
embryonic lethality during organogenesis, complete penetrance J:171522
impaired cranial neural crest cell differentiation J:171522
second pharyngeal arch hypoplasia J:171522
small frontonasal prominence J:171522
Med23tm1.1Pkb/Med23tm1.1Pkb
129S(B6)-Med23tm1.1Pkb/J 		no abnormal phenotype detected J:101977
Med23tm1Berk/Med23tm1Berk
involves: 129S4/SvJae 		abnormal nervous system development J:188551
abnormal vascular development J:188551
embryonic growth retardation J:188551
embryonic lethality during organogenesis, complete penetrance J:188551
Med23tm1c(KOMP)Wtsi/Med23tm1c(KOMP)Wtsi
H2az2Tg(Wnt1-cre)11Rth/H2az2+
involves: C57BL/6J * C57BL/6N * CBA/J 		abnormal cranial cartilage development J:304767
abnormal craniofacial morphology J:304767
abnormal cranium morphology J:304767
abnormal first pharyngeal arch morphology J:304767
abnormal frontonasal prominence morphology J:304767
abnormal Meckel's cartilage morphology J:304767
abnormal nasal cartilage morphology J:304767
abnormal palatal mesenchymal cell proliferation J:304767
abnormal secondary palate development J:304767
abnormal suckling behavior J:304767
abnormal tongue morphology J:304767
abnormal tooth development J:304767
abnormal tympanic ring morphology J:304767
absent mandibular symphysis J:304767
absent palatine bone J:304767
normal cellular phenotype J:304767
cleft palate J:304767
normal embryo phenotype J:304767
failure of palatal shelf elevation J:304767
frontal bone hypoplasia J:304767
glossoptosis J:304767
growth retardation of incisors J:304767
growth retardation of molars J:304767
mandible hypoplasia J:304767
mandibular condyloid process hypoplasia J:304767
Meckel's cartilage hypoplasia J:304767
micrognathia J:304767
nasal cartilage hypoplasia J:304767
neonatal lethality, complete penetrance J:304767
normal nervous system phenotype J:304767
palatal shelf hypoplasia J:304767
palatal shelves fail to meet at midline J:304767
respiratory distress J:304767
small lower incisors J:304767
small mandible J:304767
temporal bone hypoplasia J:304767
Med23tm1Gwan/Med23tm1Gwan
involves: 129 * C57BL/6 		abnormal cell differentiation J:187746
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory