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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Rnf168
ring finger protein 168
MGI:1917488
53 phenotypes from 4 alleles in 3 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Rnf168em1(IMPC)H/Rnf168em1(IMPC)H
C57BL/6NTac-Rnf168em1(IMPC)H/H 		abnormal coat/hair pigmentation J:211773
abnormal snout morphology J:211773
cornea opacity J:211773
increased circulating alanine transaminase level J:211773
increased circulating creatine kinase level J:211773
increased grip strength J:211773
narrow eye opening J:211773
Rnf168Gt(156B6)Cmhd/Rnf168Gt(156B6)Cmhd
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		abnormal cell cycle checkpoint function J:198260
abnormal class switch recombination J:198260
abnormal Leydig cell morphology J:198260
abnormal male germ cell morphology J:198260
abnormal T cell receptor delta chain V(D)J recombination J:198260
chromosomal instability J:198260
decreased gamma-delta T cell number J:198260
decreased IgG1 level J:198260
decreased IgG2a level J:198260
decreased IgG3 level J:198260
decreased IgG level J:198260
decreased litter size J:198260
decreased male germ cell number J:198260
normal immune system phenotype J:198260
increased cellular sensitivity to ionizing radiation J:198260
increased cellular sensitivity to ultraviolet irradiation J:198260
increased DN3 thymocyte number J:198260
increased double-negative T cell number J:198260
normal neoplasm J:198260
reduced male fertility J:198260
small testis J:198260
testicular atrophy J:198260
Rnf168Gt(405F11)Cmhd/Rnf168Gt(405F11)Cmhd
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		abnormal cell cycle checkpoint function J:198260
abnormal class switch recombination J:198260
abnormal Leydig cell morphology J:198260
abnormal male germ cell morphology J:198260
abnormal T cell receptor delta chain V(D)J recombination J:198260
chromosomal instability J:198260
decreased gamma-delta T cell number J:198260
decreased IgG1 level J:198260
decreased IgG2a level J:198260
decreased IgG3 level J:198260
decreased IgG level J:198260
decreased litter size J:198260
decreased male germ cell number J:198260
normal immune system phenotype J:198260
increased cellular sensitivity to ionizing radiation J:198260
increased cellular sensitivity to ultraviolet irradiation J:198260
increased DN3 thymocyte number J:198260
increased double-negative T cell number J:198260
normal neoplasm J:198260
reduced male fertility J:198260
small testis J:198260
testicular atrophy J:198260
Rnf168tm2b(EUCOMM)Hmgu/Rnf168tm2b(EUCOMM)Hmgu
C57BL/6N-Rnf168tm2b(EUCOMM)Hmgu/Ccpcz 		abnormal cornea morphology J:211773
abnormal cranium morphology J:211773
abnormal eye morphology J:211773
abnormal head morphology J:211773
abnormal heart morphology J:211773
abnormal skin morphology J:211773
abnormal spine curvature J:211773
abnormal spleen morphology J:211773
abnormal thymus morphology J:211773
anophthalmia J:211773
decreased body weight J:211773
decreased erythrocyte cell number J:211773
decreased hematocrit J:211773
decreased hemoglobin content J:211773
enlarged heart J:211773
enlarged thymus J:211773
fused cornea and lens J:211773
increased circulating alanine transaminase level J:211773
increased circulating aspartate transaminase level J:211773
increased circulating creatine kinase level J:211773
increased circulating lactate dehydrogenase level J:211773
increased circulating phosphate level J:211773
increased eosinophil cell number J:211773
increased grip strength J:211773
increased mean platelet volume J:211773
microphthalmia J:211773
vertebral fusion J:211773
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory