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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Wwtr1
WW domain containing transcription regulator 1
MGI:1917649
52 phenotypes from 7 alleles in 9 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Wwtr1Gt(CSD245)Byg/Wwtr1Gt(CSD245)Byg
involves: 129P2/OlaHsd 		kidney cyst J:160312
Wwtr1tm1.1Eno/Wwtr1tm1.1Eno
Tg(Myh6-cre)2182Mds/0
involves: 129S/SvEv * FVB/N 		normal cardiovascular system phenotype J:200670
Wwtr1tm1.2Eno/Wwtr1tm1.2Eno
involves: 129S/SvEv 		polycystic kidney J:200670
Wwtr1tm1Benj/Wwtr1tm1Benj
129S6/SvEvTac-Wwtr1tm1Benj 		abnormal pulmonary alveolus wall morphology J:125326
decreased body size J:125326
decreased fat cell size J:125326
decreased locomotor activity J:125326
emphysema J:125326
enlarged kidney J:125326
hydronephrosis J:125326
intestinal inflammation J:125326
kidney cortex cyst J:125326
lung inflammation J:125326
overexpanded pulmonary alveolus J:125326
polycystic kidney J:125326
prenatal lethality, incomplete penetrance J:125326
Wwtr1tm1Benj/Wwtr1tm1Benj
129S-Wwtr1tm1Benj/J 		abnormal pulmonary alveolus wall morphology J:156586
decreased body size J:156586
decreased fat cell size J:156586
decreased locomotor activity J:156586
emphysema J:156586
enlarged kidney J:156586
intestinal inflammation J:156586
lung inflammation J:156586
overexpanded pulmonary alveolus J:156586
polycystic kidney J:156586
premature death J:156586
prenatal lethality, incomplete penetrance J:156586
reduced female fertility J:156586
Wwtr1tm1Hku/Wwtr1+
B6.Cg-Wwtr1tm1Hku 		decreased susceptibility to injury J:164957
Wwtr1tm1Hku/Wwtr1tm1Hku
involves: 129 * C57BL/6 * ICR 		abnormal lung development J:164957
abnormal lung vasculature morphology J:164957
abnormal respiratory mechanics J:164957
alveolitis J:164957
decreased lung elastance J:164957
decreased pulmonary alveolus wall thickness J:164957
decreased urine osmolality J:132020
emphysema J:132020, J:164957
enlarged kidney J:132020
enlarged lung J:164957
hydronephrosis J:132020
impaired lung alveolus development J:164957
lung inflammation J:164957
overexpanded pulmonary alveolus J:132020
pale kidney J:132020
pale lung J:164957
perinatal lethality, incomplete penetrance J:132020
polycystic kidney J:132020
polyuria J:132020
postnatal lethality, incomplete penetrance J:132020
pulmonary fibrosis J:164957
renal interstitial fibrosis J:132020
Wwtr1tm1Hmc/Wwtr1tm1Hmc
Six2tm1(tTA,tetO-EGFP/cre)Amc/Six2+
involves: 129 * 129S1/Sv * 129X1/SvJ * C57BL/6J 		kidney cyst J:195266
kidney hemorrhage J:195266
Wwtr1tm1Whun/Wwtr1tm1Whun
either: (involves: 129S6/SvEvTac) or (involves: 129S6/SvEvTac * C57BL/6) 		abnormal bone ossification J:119488
abnormal renal tubule epithelial cell primary cilium morphology J:119488
abnormal renal tubule morphology J:119488
abnormal skeleton morphology J:119488
decreased body height J:119488
decreased body weight J:119488
decreased litter size J:119488
dilated distal convoluted tubule J:119488
dilated proximal convoluted tubule J:119488
dilated renal tubule J:119488
enlarged kidney J:119488
increased blood urea nitrogen level J:119488
increased glomerular capsule space J:119488
kidney corticomedullary cyst J:119488
kidney cyst J:119488
kidney failure J:119488
pale kidney J:119488
premature death J:119488
preweaning lethality, incomplete penetrance J:119488
renal glomerulus atrophy J:119488
renal interstitial fibrosis J:119488
tubular nephritis J:119488
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory