Wwtr1 Phenotype Annotations - Multigenic Genotypes

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Wwtr1
WW domain containing transcription regulator 1
MGI:1917649

19 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Lats1^tm1Noj/Lats1^tm1Noj Lats2^tm1.1Dupa/Lats2^tm1.1Dupa Wwtr1^tm1.2Eno/Wwtr1^tm1.2Eno Yap1^tm1.1Dupa/Yap1^tm1.1Dupa involves: 129P2/OlaHsd * 129S/SvEv * 129S2/SvPas	abnormal bile duct epithelium morphology	J:223215
	enlarged liver	J:223215
Mob1a^tm1.1Asuz/Mob1a^tm1.1Asuz Mob1b^{Gt(CC0690)Wtsi}/Mob1b^{Gt(CC0690)Wtsi} Wwtr1^tm1Hku/Wwtr1^tm1Hku Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺ involves: 129P2/OlaHsd * C57BL/6 * DBA	abnormal cholangiocyte morphology	J:228499
	increased liver weight	J:228499
	liver fibrosis	J:228499
Wwtr1^tm1.1Eno/Wwtr1⁺ Yap1^tm1.1Eno/Yap1^tm1.1Eno Tg(Myh6-cre)2182Mds/0 involves: 129S/SvEv * FVB/N	increased cardiomyocyte apoptosis	J:200670
	myocardium hypoplasia	J:200670
	postnatal lethality, complete penetrance	J:200670
	thin myocardium	J:200670
Wwtr1^tm1.1Eno/Wwtr1^tm1.1Eno Yap1^tm1.1Eno/Yap1⁺ Tg(Myh6-cre)2182Mds/0 involves: 129S/SvEv * FVB/N	abnormal atrial thrombosis	J:200670
	dilated cardiomyopathy	J:200670
	premature death	J:200670
Wwtr1^tm1.1Eno/Wwtr1^tm1.1Eno Yap1^tm1.1Eno/Yap1^tm1.1Eno Tg(Myh6-cre)2182Mds/0 involves: 129S/SvEv * FVB/N	abnormal heart morphology	J:200670
	neonatal lethality, complete penetrance	J:200670
Wwtr1^tm1Hku/Wwtr1^tm1Hku Yap1^tm1Smil/Yap1^tm1Smil involves: 129S/SvEv	embryonic lethality before implantation, complete penetrance	J:147050
Wwtr1^tm1Hmc/Wwtr1^tm1Hmc Yap1^tm1Hmc/Yap1^tm1Hmc Six2^{tm1(tTA,tetO-EGFP/cre)Amc}/Six2⁺ involves: 129 * 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6J * C57BL/6NCrl	abnormal kidney development	J:195266
	decreased renal glomerulus number	J:195266
	decreased renal tubule number	J:195266
	kidney cyst	J:195266

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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