Pak4 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Pak4
p21 (RAC1) activated kinase 4
MGI:1917834

26 phenotypes from 3 alleles in 4 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Meox2^tm1(cre)Sor/Meox2⁺ Pak4^tm2.1Amin/Pak4^tm2.2Amin involves: 129S2/SvPas * 129S4/SvJaeSor * C57BL/6 * FVB/N	abnormal placenta labyrinth morphology	J:152821
	abnormal visceral yolk sac morphology	J:152821
Pak4^tm1Amin/Pak4^tm1Amin either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129S2/SvPas * C57BL/6)	abnormal axon extension	J:85954
	abnormal brain morphology	J:85954
	abnormal cell adhesion	J:85954
	abnormal motor neuron morphology	J:85954
	abnormal nervous system development	J:85954
	abnormal neural tube morphology	J:85954
	abnormal neuron differentiation	J:85954
	abnormal neuronal migration	J:85954
	abnormal ventral interneuron morphology	J:85954
	decreased embryo size	J:85954
	decreased embryonic neuroepithelium thickness	J:85954
	dilated heart	J:85954
	embryonic lethality during organogenesis, complete penetrance	J:85954
	thin myocardium	J:85954
	thin ventricular wall	J:85954
Pak4^tm1Amin/Pak4^tm1Amin either: (involves: 129P2/OlaHsd * C57BL/6J) or (involves: 129S2/SvPas * C57BL/6J)	abnormal placenta labyrinth morphology	J:152821
	abnormal placenta vasculature	J:152821
	abnormal visceral yolk sac morphology	J:152821
	abnormal vitelline vascular remodeling	J:152821
	decreased cell proliferation	J:152821
	decreased embryo size	J:152821
	embryonic growth retardation	J:152821
	increased apoptosis	J:152821
	pale placenta	J:152821
	pale yolk sac	J:152821
	pallor	J:152821
Pak4^tm2.1Amin/Pak4^tm2.2Amin Edil3^{Tg(Sox2-cre)1Amc}/Edil3⁺ involves: 129S2/SvPas * C57BL/6 * CBA * FVB/N	abnormal placenta labyrinth morphology	J:152821
	abnormal visceral yolk sac morphology	J:152821
	embryonic growth retardation	J:152821
	preweaning lethality, complete penetrance	J:152821

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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