Hacd2 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Hacd2
3-hydroxyacyl-CoA dehydratase 2
MGI:1918007

46 phenotypes from 4 alleles in 3 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Hacd2^{tm1a(EUCOMM)Hmgu}/Hacd2^{tm1a(EUCOMM)Hmgu} involves: C57BL/6N	abnormal brown adipose tissue thermogenesis	J:333944
	abnormal mitochondrial ATP synthesis coupled electron transport	J:333944
	abnormal mitochondrial physiology	J:333944
	abnormal oxidative phosphorylation	J:333944
	cachexia	J:333944
	decreased body weight	J:333944
	normal homeostasis/metabolism phenotype	J:333944
	hypoglycemia	J:333944
	increased circulating lactate level	J:333944
	lactic acidosis	J:333944
	lethargy	J:333944
	postnatal growth retardation	J:333944
	postnatal lethality, complete penetrance	J:333944
Hacd2^{tm1b(EUCOMM)Hmgu}/Hacd2^{tm1b(EUCOMM)Hmgu} involves: C57BL/6N	abnormal cardiovascular development	J:333944
	abnormal cranial blood vasculature morphology	J:333944
	abnormal embryo morphology	J:333944
	abnormal heart development	J:333944
	abnormal heart looping	J:333944
	abnormal lipid oxidation	J:333944
	abnormal mitochondrial ATP synthesis coupled electron transport	J:333944
	abnormal mitochondrial crista morphology	J:333944
	abnormal mitochondrial morphology	J:333944
	abnormal oxidative phosphorylation	J:333944
	abnormal pharyngeal arch morphology	J:333944
	abnormal phospholipid level	J:333944
	abnormal posterior cardinal vein morphology	J:333944
	abnormal tail development	J:333944
	abnormal vascular branching morphogenesis	J:333944
	abnormal vascular development	J:333944
	abnormal vitelline vasculature morphology	J:333944
	absent embryonic telencephalon	J:333944
	absent limb buds	J:333944
	absent optic vesicle	J:333944
	absent vitelline blood vessels	J:333944
	decreased embryo size	J:333944
	delayed head development	J:333944
	delayed rostral neuropore closure	J:333944
	delayed somite formation	J:333944
	dilated mitochondrion	J:333944
	embryonic growth arrest	J:333944
	embryonic growth retardation	J:333944
	embryonic lethality during organogenesis, complete penetrance	J:333944
	hemopericardium	J:333944
	incomplete embryo turning	J:333944
	pale yolk sac	J:333944
	pericardial edema	J:333944
	thin myocardium	J:333944
Hacd2^{tm1b(EUCOMM)Hmgu}/Hacd2^{tm1c(EUCOMM)Hmgu} Mesp1^tm2(cre)Ysa/Mesp1⁺ involves: C57BL/6N * C57BL/6NCrlj * CBA/JNCrlj	no abnormal phenotype detected	J:333944
Hacd2^{tm1b(EUCOMM)Hmgu}/Hacd2^{tm1c(EUCOMM)Hmgu} Tg(Tek-cre)1Ywa/0 involves: C57BL/6 * C57BL/6N * SJL	no abnormal phenotype detected	J:333944
Hacd2^{tm1d(EUCOMM)Hmgu}/Hacd2^{tm1d(EUCOMM)Hmgu} involves: C57BL/6N	embryonic lethality during organogenesis, complete penetrance	J:333944

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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