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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Phf6
PHD finger protein 6
MGI:1918248
62 phenotypes from 6 alleles in 7 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Phf6em1Azbi/Y
B6.Cg-Phf6em1Azbi 		abnormal action potential J:271089
abnormal neuron physiology J:271089
abnormal object recognition memory J:271089
abnormal social recognition J:271089
decreased body length J:271089
decreased body weight J:271089
decreased exploration in new environment J:271089
decreased single cell response threshold J:271089
decreased startle reflex J:271089
decreased vertical activity J:271089
impaired contextual conditioning behavior J:271089
increased single cell response intensity J:271089
increased susceptibility to pharmacologically induced seizures J:271089
Phf6em1Wencc/Phf6em1Wencc
Tg(Vav1-cre)#Cgp/0
Not Specified 		abnormal effector T cell number J:278804
abnormal megakaryocyte morphology J:278804
abnormal splenic cell ratio J:278804
abnormal thymus cell ratio J:278804
decreased bone marrow cell number J:278804
decreased CD4-positive, alpha-beta T cell number J:278804
decreased CD8-positive, alpha-beta T cell number J:278804
decreased double-negative T cell number J:278804
decreased granulocyte monocyte progenitor cell number J:278804
decreased hematopoietic stem cell number J:278804
decreased lymphocyte cell number J:278804
enlarged spleen J:278804
extramedullary hematopoiesis J:278804
normal immune system phenotype J:278804
increased B cell number J:278804
increased bone marrow cell number J:278804
increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number J:278804
increased hematopoietic stem cell number J:278804
increased hematopoietic stem cell proliferation J:278804
increased leukocyte cell number J:278804
increased megakaryocyte cell number J:278804
increased pro-B cell number J:278804
normal skeleton phenotype J:278804
thrombocytopenia J:278804
Phf6em1Wencc/Y
Tg(Vav1-cre)#Cgp/0
Not Specified 		abnormal effector T cell number J:278804
abnormal megakaryocyte morphology J:278804
abnormal splenic cell ratio J:278804
abnormal thymus cell ratio J:278804
decreased bone marrow cell number J:278804
decreased CD4-positive, alpha-beta T cell number J:278804
decreased CD8-positive, alpha-beta T cell number J:278804
decreased double-negative T cell number J:278804
decreased granulocyte monocyte progenitor cell number J:278804
decreased hematopoietic stem cell number J:278804
decreased lymphocyte cell number J:278804
enlarged spleen J:278804
extramedullary hematopoiesis J:278804
normal hematopoietic system phenotype J:278804
normal immune system phenotype J:278804
increased B cell number J:278804
increased bone marrow cell number J:278804
increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number J:278804
increased hematopoietic stem cell number J:278804
increased hematopoietic stem cell proliferation J:278804
increased megakaryocyte cell number J:278804
increased pro-B cell number J:278804
normal skeleton phenotype J:278804
thrombocytopenia J:278804
Phf6em2Azbi/Y
involves: C57BL/6 * CBA 		perinatal lethality, complete penetrance J:271089
Phf6em2Azbi/Phf6em2Azbi
involves: C57BL/6 * CBA 		perinatal lethality, complete penetrance J:271089
Phf6tm1.1Avo/Y
Tg(Nes-cre)1Kln/0
involves: C57BL/6 * SJL 		decreased body size J:299742
decreased body weight J:299742
Phf6tm1.1Avo/Y
Tg(Tek-cre)1Ywa/0
involves: C57BL/6 * SJL 		abnormal hematopoietic precursor cell morphology J:276228
abnormal hematopoietic system physiology J:276228
abnormal T cell differentiation J:276228
decreased DN2 thymocyte number J:276228
decreased hematopoietic stem cell number J:276228
increased circulating interferon-alpha level J:276228
increased common lymphocyte progenitor cell number J:276228
increased hematopoietic precursor cell number J:276228
increased hematopoietic stem cell number J:276228
increased hematopoietic stem cell proliferation J:276228
increased leukemia incidence J:276228
increased plasmacytoid dendritic cell number J:276228
Phf6tm1.2Avo/Y
involves: BALB/c * BALB/cJ * C57BL/6 * FVB/N 		decreased adrenocorticotropin level J:299742
decreased body size J:299742
decreased body weight J:299742
decreased circulating growth hormone level J:299742
decreased circulating insulin-like growth factor I level J:299742
decreased growth hormone level J:299742
decreased lean body mass J:299742
decreased prolactin level J:299742
increased white adipose tissue amount J:299742
normal mortality/aging J:299742
postnatal lethality, incomplete penetrance J:299742
normal reproductive system phenotype J:299742
small pituitary gland J:299742
Phf6tm1.2Avo/Y
involves: BALB/cJ * C57BL/6 		perinatal lethality, complete penetrance J:276228, J:299742
Phf6tm1.2Avo/Phf6+
involves: BALB/cJ * C57BL/6 		decreased body weight J:299742
increased leukemia incidence J:276228
Phf6tm1.2Avo/Phf6tm1.2Avo
involves: BALB/c * BALB/cJ * C57BL/6 * FVB/N 		decreased body size J:299742
Phf6tm1b(EUCOMM)Wtsi/Phf6+
C57BL/6N-Phf6tm1b(EUCOMM)Wtsi/Ics 		abnormal auditory brainstem response J:211773
Phf6tm1b(EUCOMM)Wtsi/Phf6tm1b(EUCOMM)Wtsi
C57BL/6N-Phf6tm1b(EUCOMM)Wtsi/Ics 		preweaning lethality, complete penetrance J:211773
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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12/10/2024
MGI 6.24 		The Jackson Laboratory