Mus81 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Mus81
MUS81 structure-specific endonuclease subunit
MGI:1918961

46 phenotypes from 3 alleles in 6 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Mus81^tm1Chmg/Mus81^tm1Chmg involves: 129S4/SvJae * 129S5/SvEvBrd * C57BL/6	decreased cell proliferation	J:100407
	increased susceptibility to xenobiotic induced morbidity/mortality	J:100407
Mus81^tm1Chmg/Mus81^tm1Chmg involves: 129S5/SvEvBrd	normal cardiovascular system phenotype	J:133703
Mus81^tm1Chmg/Mus81^tm1Chmg involves: 129S5/SvEvBrd	increased physiological sensitivity to xenobiotic	J:232402
Mus81^tm1Chmg/Mus81^tm1Chmg involves: 129S5/SvEvBrd * C57BL/6	abnormal DNA repair	J:204996
	increased sensitivity to induced cell death	J:204996
Mus81^tm1Esse/Mus81⁺ involves: 129P2/OlaHsd * C57BL/6	abnormal aorta wall morphology	J:133703
Mus81^tm1Esse/Mus81⁺ involves: 129P2/OlaHsd * C57BL/6	abnormal subclavian artery morphology	J:133703
Mus81^tm1Esse/Mus81⁺ involves: 129P2/OlaHsd * C57BL/6J	abnormal aorta elastic tissue morphology	J:222498
	abnormal aorta morphology	J:222498
	abnormal aorta tunica media morphology	J:222498
	abnormal lung morphology	J:222498
	emphysema	J:222498
	increased inflammatory response	J:222498
	overexpanded pulmonary alveolus	J:222498
Mus81^tm1Esse/Mus81^tm1Esse involves: 129P2/OlaHsd * C57BL/6	abnormal aorta elastic tissue morphology	J:133703
	abnormal aorta morphology	J:133703
	abnormal aorta tunica adventitia morphology	J:133703
	abnormal aorta wall morphology	J:133703
	abnormal aortic valve morphology	J:133703
	abnormal blood flow velocity	J:133703
	abnormal cardiovascular system physiology	J:133703
	abnormal heart ventricle pressure	J:133703
	abnormal thoracic aorta morphology	J:133703
	aortic aneurysm	J:133703
	aortic dissection	J:133703
	aortic valve regurgitation	J:133703
	aortic valve stenosis	J:133703
	dilated ascending aorta	J:133703
	heart left ventricle hypertrophy	J:133703
	hemopericardium	J:133703
	increased aorta wall thickness	J:133703
	increased cardiac stroke volume	J:133703
	increased left ventricle diastolic pressure	J:133703
	increased pulse pressure	J:133703
	internal hemorrhage	J:133703
	postnatal lethality, incomplete penetrance	J:133703
Mus81^tm1Esse/Mus81^tm1Esse involves: 129P2/OlaHsd * C57BL/6J	abnormal aorta elastic tissue morphology	J:222498
	abnormal aorta morphology	J:222498
	abnormal aorta tunica media morphology	J:222498
	abnormal lung morphology	J:222498
	ascending aorta aneurysm	J:222498
	emphysema	J:222498
	increased interleukin-1 beta secretion	J:222498
	lung inflammation	J:222498
	overexpanded pulmonary alveolus	J:222498
Mus81^tm1Raz/Mus81⁺ involves: 129P2/OlaHsd	chromosome breakage	J:91570
	increased adenoma incidence	J:91570
	increased carcinoma incidence	J:91570
	increased lymphoma incidence	J:91570
	premature death	J:91570
Mus81^tm1Raz/Mus81^tm1Raz involves: 129P2/OlaHsd	chromosome breakage	J:91570
	normal immune system phenotype	J:91570
	increased B cell derived lymphoma incidence	J:91570
	increased carcinoma incidence	J:91570
	increased lymphoma incidence	J:91570
	increased mortality induced by gamma-irradiation	J:91570
	increased susceptibility to xenobiotic induced morbidity/mortality	J:91570
	premature death	J:91570
	normal reproductive system phenotype	J:91570

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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