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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Pdia6
protein disulfide isomerase associated 6
MGI:1919103
38 phenotypes from 3 alleles in 4 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Pdia6em1Btlr/Pdia6em1Btlr
Not Specified 		preweaning lethality, complete penetrance J:288824
Pdia6em1Btlr/Pdia6m1Btlr
involves: C57BL/6J 		abnormal circulating cytokine level J:288824
abnormal T cell physiology J:288824
decreased B cell number J:288824
decreased body size J:288824
decreased body weight J:288824
decreased circulating insulin level J:288824
decreased circulating insulin-like growth factor I level J:288824
decreased circulating triglyceride level J:288824
decreased common lymphocyte progenitor cell number J:288824
decreased common myeloid progenitor cell number J:288824
decreased double-negative T cell number J:288824
decreased double-positive T cell number J:288824
decreased follicular B cell number J:288824
decreased hematopoietic stem cell number J:288824
decreased leukocyte cell number J:288824
decreased lymphocyte cell number J:288824
decreased monocyte cell number J:288824
decreased NK T cell number J:288824
decreased pre-B cell number J:288824
decreased transitional stage B cell number J:288824
normal endocrine/exocrine gland phenotype J:288824
normal hematopoietic system phenotype J:288824
increased fasting circulating glucose level J:288824
increased granulocyte monocyte progenitor cell number J:288824
increased marginal zone B cell number J:288824
increased marginal zone precursor B cell number J:288824
increased mature B cell number J:288824
insulin resistance J:288824
spleen hypoplasia J:288824
thrombocytopenia J:288824
thymus hypoplasia J:288824
Pdia6m1Btlr/Pdia6m1Btlr
C57BL/6J-Pdia6m1Btlr 		decreased body weight J:288824
normal immune system phenotype J:288824
Pdia6tm1b(EUCOMM)Hmgu/Pdia6+
C57BL/6N-Pdia6tm1b(EUCOMM)Hmgu/Ieg 		abnormal gait J:211773
decreased CD4-positive NK T cell number J:211773
enlarged lymph nodes J:211773
enlarged thyroid gland J:211773
increased total body fat amount J:211773
Pdia6tm1b(EUCOMM)Hmgu/Pdia6tm1b(EUCOMM)Hmgu
C57BL/6N-Pdia6tm1b(EUCOMM)Hmgu/Ieg 		preweaning lethality, complete penetrance J:211773
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory