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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Atad3a
ATPase family, AAA domain containing 3A
MGI:1919214
35 phenotypes from 3 alleles in 3 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Atad3aGt(E118D03)Wrst/Atad3aGt(E118D03)Wrst
involves: 129P2/OlaHsd * C57BL/6J 		abnormal developmental patterning J:195793
abnormal ectoderm development J:195793
abnormal ectoplacental cone morphology J:195793
abnormal embryo development J:195793
abnormal endoderm development J:195793
abnormal extraembryonic ectoderm morphology J:195793
abnormal proximal-distal axis patterning J:195793
abnormal trophectoderm morphology J:195793
absent ectoplacental cone J:195793
absent extraembryonic ectoderm J:195793
embryonic growth retardation J:195793
embryonic lethality between implantation and placentation, complete penetrance J:195793
failure to gastrulate J:195793
small embryonic epiblast J:195793
Atad3atm1a(KOMP)Wtsi/Atad3a+
C57BL/6N-Atad3atm1a(KOMP)Wtsi/Wtsi 		decreased circulating cholesterol level J:211773
decreased circulating HDL cholesterol level J:211773
Atad3atm1a(KOMP)Wtsi/Atad3atm1a(KOMP)Wtsi
C57BL/6N-Atad3atm1a(KOMP)Wtsi/Wtsi 		preweaning lethality, complete penetrance J:211773
Atad3atm1c(KOMP)Wtsi/Atad3atm1c(KOMP)Wtsi
Myl1tm1(cre)Sjb/Myl1+
B6J.Cg-Myl1tm1(cre)Sjb Atad3atm1c(KOMP)Wtsi 		abnormal cholesterol homeostasis J:263681
abnormal mitochondrial crista morphology J:263681
abnormal motor coordination/balance J:263681
abnormal muscle fiber mitochondrial morphology J:263681
abnormal muscle fiber morphology J:263681
abnormal oxidative phosphorylation J:263681
cachexia J:263681
decreased grip strength J:263681
decreased locomotor activity J:263681
decreased mitochondrial size J:263681
decreased skeletal muscle fiber mitochondrial DNA content J:263681
decreased skeletal muscle weight J:263681
disorganized mitochondrial cristae J:263681
normal growth/size/body region phenotype J:263681
kyphosis J:263681
skeletal muscle fiber atrophy J:263681
skeletal muscle fiber degeneration J:263681
weakness J:263681
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory