Ercc8 Phenotype Annotations

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Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Ercc8
excision repaiross-complementing rodent repair deficiency, complementation group 8
MGI:1919241

17 phenotypes from 2 alleles in 3 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Ercc8^em1(IMPC)H/Ercc8^em1(IMPC)H C57BL/6N-Ercc8^em1(IMPC)H/H	abnormal locomotor behavior	J:211773
	increased circulating cholesterol level	J:211773
	increased circulating HDL cholesterol level	J:211773
Ercc8^tm1Jhjh/Ercc8^tm1Jhjh B6J.129P2-Ercc8^tm1Jhjh	cochlear inner hair cell degeneration	J:219993
	cochlear outer hair cell degeneration	J:219993
	decreased distortion product otoacoustic emission amplitude	J:219993
	impaired hearing	J:219993
	increased or absent threshold for auditory brainstem response	J:219993
Ercc8^tm1Jhjh/Ercc8^tm1Jhjh involves: 129P2/OlaHsd * C57BL/6J	abnormal DNA repair	J:74959
	astrocytosis	J:179808
	increased cellular sensitivity to ultraviolet irradiation	J:74959
	increased incidence of tumors by UV-induction	J:74959
	increased sensitivity to skin irradiation	J:74959
	microgliosis	J:179808
	photophobia	J:74959
	retina photoreceptor degeneration	J:74959
	skin photosensitivity	J:74959

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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