Slc39a4 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Slc39a4
solute carrier family 39 (zinc transporter), member 4
MGI:1919277

43 phenotypes from 3 alleles in 4 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Slc39a4^{tm1.1(KOMP)Wtsi}/Slc39a4⁺ C57BL/6N-Slc39a4^{tm1.1(KOMP)Wtsi}/MbpMmucd	abnormal forebrain development	J:211773
	abnormal hindbrain development	J:211773
	abnormal midbrain development	J:211773
	abnormal neural tube closure	J:211773
Slc39a4^{tm1.1(KOMP)Wtsi}/Slc39a4⁺ C57BL/6N-Slc39a4^{tm1.1(KOMP)Wtsi}/Ucd	increased fasting circulating glucose level	J:211773
Slc39a4^{tm1.1(KOMP)Wtsi}/Slc39a4^{tm1.1(KOMP)Wtsi} C57BL/6N-Slc39a4^{tm1.1(KOMP)Wtsi}/MbpMmucd	embryonic lethality prior to organogenesis	J:211773
	embryonic lethality prior to tooth bud stage	J:211773
Slc39a4^{tm1.1(KOMP)Wtsi}/Slc39a4^{tm1.1(KOMP)Wtsi} C57BL/6N-Slc39a4^{tm1.1(KOMP)Wtsi}/Ucd	preweaning lethality, complete penetrance	J:211773
Slc39a4^tm1Gka/Slc39a4⁺ involves: 129S1/Sv * C57BL/6 * FVB/N	abnormal craniofacial development	J:125096
	abnormal embryo development	J:125096
	abnormal head morphology	J:125096
	abnormal heart left ventricle morphology	J:125096
	abnormal skeleton morphology	J:125096
	anophthalmia	J:125096
	decreased body size	J:125096
	decreased embryo size	J:125096
	embryonic growth retardation	J:125096
	embryonic lethality during organogenesis, incomplete penetrance	J:125096
	exencephaly	J:125096
	hydrocephaly	J:125096
	maternal effect	J:125096
	postnatal lethality, incomplete penetrance	J:125096
	thick interventricular septum	J:125096
Slc39a4^tm1Gka/Slc39a4^tm1Gka involves: 129S1/Sv * C57BL/6 * FVB/N	embryonic lethality during organogenesis, complete penetrance	J:125096
Slc39a4^tm2Gka/Slc39a4^tm2Gka Tg(Vil1-cre/ERT2)23Syr/0 involves: 129P2/OlaHsd * C57BL/6 * DBA/2	abnormal copper level	J:187178
	abnormal liver morphology	J:187178
	abnormal mineral homeostasis	J:187178
	abnormal Paneth cell morphology	J:187178
	abnormal small intestinal crypt cell proliferation	J:187178
	abnormal small intestinal villus morphology	J:187178
	abnormal small intestine crypts of Lieberkuhn morphology	J:187178
	abnormal zinc homeostasis	J:187178
	decreased bone mass	J:187178
	decreased intestinal iron level	J:187178
	decreased intestine copper level	J:187178
	decreased liver copper level	J:187178
	decreased muscle weight	J:187178
	increased liver copper level	J:187178
	increased liver iron level	J:187178
	lethality at weaning, complete penetrance	J:187178
	postnatal growth retardation	J:187178
	premature death	J:187178
	weight loss	J:187178

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24