Ush1c Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Ush1c
USH1 protein network component harmonin
MGI:1919338

49 phenotypes from 9 alleles in 11 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Ush1c^dfcr-2J/Ush1c^dfcr-2J B6;129S4	abnormal inner hair cell stereociliary bundle morphology	J:85400
	abnormal outer hair cell stereociliary bundle morphology	J:85400
	circling	J:85400
	cochlear inner hair cell degeneration	J:85400
	cochlear outer hair cell degeneration	J:85400
	deafness	J:85400
	head tossing	J:85400
	impaired balance	J:85400
	increased or absent threshold for auditory brainstem response	J:85400
	vestibular hair cell degeneration	J:85400
Ush1c^dfcr-3J/Ush1c^dfcr-3J STOCK Ush1c^dfcr-3J/J	circling	J:147859
	deafness	J:147859
	head bobbing	J:147859
	normal vision/eye phenotype	J:147859
Ush1c^dfcr-4J/Ush1c^dfcr-4J 129P3/J-Ush1c^dfcr-4J/J	circling	J:278662
	deafness	J:278662
	head tossing	J:278662
	impaired swimming	J:278662
	increased or absent threshold for auditory brainstem response	J:278662
Ush1c^dfcr/Ush1c^dfcr involves: BALB/cByJ	abnormal inner hair cell stereociliary bundle morphology	J:85400
	abnormal outer hair cell stereociliary bundle morphology	J:85400
	circling	J:85400
	cochlear inner hair cell degeneration	J:85400
	cochlear outer hair cell degeneration	J:85400
	deafness	J:85400
	head tossing	J:85400
	impaired balance	J:85400
	increased or absent threshold for auditory brainstem response	J:85400
	retina degeneration	J:85400
	vestibular hair cell degeneration	J:85400
Ush1c^dfcr/Ush1c^dfcr involves: BALB/cBySmn * C57BL/6 * C57BL/Ka	abnormal cochlear hair bundle tip links morphology	J:157359
	abnormal hair cell mechanoelectric transduction	J:157359
	cochlear ganglion degeneration	J:157359
	deafness	J:157359
	increased or absent threshold for auditory brainstem response	J:157359
	organ of Corti degeneration	J:157359
Ush1c^tm1.1Mull/Ush1c^tm1.1Mull involves: 129S/SvEv * C57BL/6 * SJL	abnormal cochlear hair cell stereociliary bundle morphology	J:157359
	circling	J:157359
	deafness	J:157359
	head tossing	J:157359
	increased or absent threshold for auditory brainstem response	J:157359
Ush1c^tm1.1Ugds/Ush1c^tm1.1Ugds involves: 129S2/SvPas	abnormal cochlear hair cell inter-stereocilial links morphology	J:135991
	abnormal cochlear outer hair cell morphology	J:158897
	abnormal inner hair cell stereociliary bundle morphology	J:135991
	abnormal orientation of cochlear hair cell stereociliary bundles	J:135991
	abnormal outer hair cell stereociliary bundle morphology	J:135991, J:141421, J:158897
Ush1c^{tm1a(KOMP)Wtsi}/Ush1c^{tm1a(KOMP)Wtsi} C57BL/6N-Ush1c^{tm1a(KOMP)Wtsi}/Wtsi	absent pinna reflex	J:211773
	decreased circulating amylase level	J:211773
	decreased circulating glucose level	J:211773
	decreased grip strength	J:211773
	decreased total body fat amount	J:211773
	impaired righting response	J:211773
	improved glucose tolerance	J:211773
	increased bone mineral content	J:211773
	increased circulating chloride level	J:211773
	increased circulating sodium level	J:211773
	increased food intake	J:211773
	increased lean body mass	J:211773
	increased red blood cell distribution width	J:211773
	limb grasping	J:211773
	stereotypic behavior	J:211773
	trunk curl	J:211773
Ush1c^tm1Bkts/Ush1c^tm1Bkts involves: 129S6/SvEvTac * C57BL/6J * FVB/N	absent pinna reflex	J:118248
	circling	J:118248
	head tossing	J:118248
	hyperactivity	J:118248
	normal reproductive system phenotype	J:118248
Ush1c^tm1Xzl/Ush1c⁺ B6.129-Ush1c^tm1Xzl	increased or absent threshold for auditory brainstem response	J:183898
Ush1c^tm1Xzl/Ush1c^tm1Xzl B6.129-Ush1c^tm1Xzl	abnormal cochlear hair cell morphology	J:158047
	abnormal cochlear outer hair cell morphology	J:158047
	abnormal electroretinogram waveform feature	J:158047
	abnormal orientation of inner hair cell stereociliary bundles	J:158047
	abnormal orientation of outer hair cell stereociliary bundles	J:158047
	abnormal outer hair cell stereociliary bundle morphology	J:158047
	circling	J:158047
	deafness	J:158047
	head tossing	J:158047
	hyperactivity	J:158047
	impaired swimming	J:158047
	increased or absent threshold for auditory brainstem response	J:158047
	normal vision/eye phenotype	J:158047
Ush1c^tm1Xzl/Ush1c^tm1Xzl involves: 129S1/Sv * 129X1/SvJ	abnormal colon morphology	J:212327
	abnormal enterocyte morphology	J:212327
	abnormal intestinal epithelium morphology	J:212327
	abnormal small intestine morphology	J:212327
	decreased small intestinal microvillus size	J:212327

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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