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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Tmem163
transmembrane protein 163
MGI:1919410
210 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background		 Annotated Term Reference
Aifm1tm2Pngr/Aifm1+
Tmem163Tg(ACTB-cre)2Mrt/0
involves: 129P2/OlaHsd * FVB/N 		decreased body size J:113016
prenatal lethality, incomplete penetrance J:113016
Aifm1tm2Pngr/Y
Tmem163Tg(ACTB-cre)2Mrt/0
involves: 129P2/OlaHsd * FVB/N 		embryonic growth retardation J:113016
embryonic lethality during organogenesis, complete penetrance J:113016
Alktm1.1(ALK*F1174L)Heno/Alktm1.1(ALK*F1174L)Heno
Tmem163Tg(ACTB-cre)2Mrt/Tmem163+
involves: 129X1/SvJ * C57BL/6 * C57BL/6N * FVB/N * SJL 		abnormal stellate ganglion morphology J:294092
normal neoplasm J:294092
Artm1Chc/Ar+
Tmem163Tg(ACTB-cre)2Mrt/0
involves: 129S/SvEv * C57BL/6J * FVB/N 		decreased litter size J:81789
Artm1Chc/Artm1.1Chc
Tmem163Tg(ACTB-cre)2Mrt/0
involves: 129S/SvEv * C57BL/6J * FVB/N 		abnormal branching of the mammary ductal tree J:87193
abnormal lactation J:87193
abnormal mammary gland morphology J:87193
abnormal nursing J:87193
decreased litter size J:81789
decreased ovary weight J:87193
decreased oviduct weight J:87193
decreased uterus weight J:87193
enlarged thymus J:87193
Artm1Chc/Y
Tmem163Tg(ACTB-cre)2Mrt/0
involves: 129S/SvEv * C57BL/6J * FVB/N 		abnormal anogenital distance J:81789
abnormal external male genitalia morphology J:81789
abnormal fat cell morphology J:81789, J:98775
abnormal long bone metaphysis morphology J:81789
abnormal scrotum morphology J:81789
abnormal seminiferous tubule morphology J:118270
abnormal Sertoli cell morphology J:81789, J:118270
abnormal spermatocyte morphology J:118270
abnormal spermatogonia morphology J:81789
abnormal trabecular bone morphology J:81789
absent epididymis J:81789
absent external male genitalia J:81789
absent prostate gland J:81789
absent seminal vesicle J:81789
absent vas deferens J:81789
arrest of male meiosis J:118270
arrest of spermatogenesis J:81789
cryptorchism J:81789, J:118270
decreased adiponectin level J:98775
decreased body weight J:81789, J:98775
decreased circulating testosterone level J:81789, J:98775, J:118270
decreased response to leptin J:81789
hyperglycemia J:98775
hypospadia J:81789
impaired glucose tolerance J:98775
increased bone ossification J:81789
increased circulating glucose level J:98775
increased circulating insulin level J:98775
increased circulating leptin level J:98775
increased circulating triglyceride level J:98775
increased gonadal fat pad weight J:98775
increased liver triglyceride level J:98775
increased osteoclast cell number J:81789
increased renal fat pad weight J:98775
increased skeletal muscle triglyceride level J:98775
increased susceptibility to weight gain J:98775
increased white adipose tissue amount J:98775
insulin resistance J:98775
Leydig cell hypertrophy J:81789
seminiferous tubule degeneration J:118270
small penis J:81789
small seminiferous tubules J:118270
small testis J:118270
testicular atrophy J:98775
testis hypoplasia J:81789
Bcortm1.1Vjba/Bcor+
Tmem163Tg(ACTB-cre)2Mrt/Tmem163+
involves: 129S1/Sv * C57BL/6N * FVB/N 		abnormal placenta labyrinth morphology J:296645
abnormal placenta morphology J:296645
abnormal spongiotrophoblast layer morphology J:296645
asymmetric snout J:296645
blepharoptosis J:296645
broad snout J:296645
cataract J:296645
cleft palate J:296645
decreased embryo size J:296645
embryonic lethality prior to tooth bud stage J:296645
increased trophoblast giant cell number J:296645
kinked tail J:296645
kyphosis J:296645
microphthalmia J:296645
neonatal lethality, incomplete penetrance J:296645
postnatal lethality, incomplete penetrance J:296645
thin placenta labyrinth J:296645
Bcortm1.1Vjba/Y
Tmem163Tg(ACTB-cre)2Mrt/Tmem163+
involves: 129S1/Sv * C57BL/6N * FVB/N 		decreased forebrain size J:296645
embryonic growth retardation J:296645
embryonic lethality between implantation and placentation, complete penetrance J:296645
Bmal1tm1.1Ljm/Bmal1tm1.1Ljm
Tmem163Tg(ACTB-cre)2Mrt/0
involves: C57BL/6 * FVB/N 		abnormal circadian behavior J:188253
decreased locomotor activity J:188253
Cochtm1Stw/Cochtm1Stw
Tmem163Tg(ACTB-cre)2Mrt/?
involves: 129S1/Sv * FVB/N 		no abnormal phenotype detected J:105566
Col1a1tm3(CAG-IDH2*R140Q)Kkw/Col1a1+
Tmem163Tg(ACTB-cre)2Mrt/0
involves: 129S4/SvJae * BALB/c * C57BL/6 * FVB/N 		cardiac hypertrophy J:209629
decreased body size J:209629
embryonic lethality, incomplete penetrance J:209629
hydrocephaly J:209629
premature death J:209629
seizures J:209629
tremors J:209629
Dppa2tm1.1Reik/Dppa2+
Tmem163Tg(ACTB-cre)2Mrt/Tmem163+
involves: C57BL/6 * FVB/N 		maternal effect J:316936
Dppa2tm2.1Reik/Dppa2tm2.1Reik
Dppa4tm2.1Reik/Dppa4tm2.1Reik
Tmem163Tg(ACTB-cre)2Mrt/Tmem163+
involves: C57BL/6 * FVB/N 		maternal effect J:316936
Dppa4tm1.1Reik/Dppa4+
Tmem163Tg(ACTB-cre)2Mrt/Tmem163+
involves: C57BL/6 * FVB/N 		maternal effect J:316936
Epb41l3tm1Bhat/Epb41l3tm1.1Bhat
Tmem163Tg(ACTB-cre)2Mrt/0
involves: FVB/N 		abnormal paranodal axoglial junction morphology J:173383
abnormal paranode morphology J:173383
Esr1tm1Syeh/Esr1tm1Syeh
Tmem163Tg(ACTB-cre)2Mrt/0
involves: 129X1/SvJ * FVB/N 		abnormal female reproductive system morphology J:147191
abnormal granulosa cell morphology J:147191
abnormal male reproductive system morphology J:147191
abnormal myometrium morphology J:147191
abnormal ovary morphology J:147191
abnormal prostate gland branching morphogenesis J:147000
abnormal prostate gland physiology J:147000
abnormal reproductive system physiology J:147191
absent corpus luteum J:147191
decreased male germ cell number J:147000
decreased primary ovarian follicle number J:147191
decreased primordial ovarian follicle number J:147191
decreased testis weight J:147000
female infertility J:147191
impaired ovarian folliculogenesis J:147191
increased atretic ovarian follicle number J:147191
increased circulating testosterone level J:147000
increased total body fat amount J:147191
male infertility J:147000
obese J:147191
oligozoospermia J:147000
ovary cyst J:147191
seminiferous tubule degeneration J:147000
small testis J:147000
uterus hypoplasia J:147191
vagina hypoplasia J:147191
Gdf7tm2Tmj/Gdf7+
Tmem163Tg(ACTB-cre)2Mrt/0
involves: 129S1/Sv * FVB/N 		abnormal forebrain morphology J:100435
absent choroid plexus J:100435
open neural tube J:100435
Grem1tm1Ecan/Grem1+
Nogtm1.1Rmh/Nogtm1.1Rmh
Tmem163Tg(ACTB-cre)2Mrt/0
involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * FVB/N * SJL 		abnormal neural tube morphology J:169133
decreased somite size J:169133
open neural tube J:169133
Grem1tm1Ecan/Grem1tm1Ecan
Nogtm1.1Rmh/Nogtm1.1Rmh
Tmem163Tg(ACTB-cre)2Mrt/0
involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * FVB/N * SJL 		abnormal brain development J:169133
abnormal head development J:169133
abnormal somite development J:169133
abnormal tail development J:169133
absent sclerotome J:169133
decreased somite size J:169133
kinked neural tube J:169133
open neural tube J:169133
Gt(ROSA)26Sortm1(Bcor*A)Vjba/Gt(ROSA)26Sor+
Tmem163Tg(ACTB-cre)2Mrt/Tmem163+
involves: 129S1/Sv * FVB/N 		abnormal eye morphology J:296645
abnormal forelimb morphology J:296645
abnormal hindbrain morphology J:296645
embryonic lethality during organogenesis, complete penetrance J:296645
short mandible J:296645
short snout J:296645
Gt(ROSA)26Sortm1(Hesx1)Jpmb/Gt(ROSA)26Sor+
Tmem163Tg(ACTB-cre)2Mrt/0
involves: 129S/SvEv * C57BL/6 * SJL 		exencephaly J:135132
Gt(ROSA)26Sortm1(Hesx1)Jpmb/Gt(ROSA)26Sortm1(Hesx1)Jpmb
Tmem163Tg(ACTB-cre)2Mrt/0
involves: 129S/SvEv * C57BL/6 * SJL 		exencephaly J:135132
Gt(ROSA)26Sortm1(Pim1-E2F1)Rebr/Gt(ROSA)26Sor+
Tmem163Tg(ACTB-cre)2Mrt/0
involves: 129P2/OlaHsd * FVB * FVB/N 		abnormal long bone epiphyseal plate proliferative zone J:83303
abnormal skeleton morphology J:83303
decreased body size J:83303
decreased width of hypertrophic chondrocyte zone J:83303
postnatal growth retardation J:83303
postnatal lethality, incomplete penetrance J:83303
Gt(ROSA)26Sortm1(Rybp/EGFP)Cve/Gt(ROSA)26Sor+
Tmem163Tg(ACTB-cre)2Mrt/0
involves: 129S1/Sv * 129X1/SvJ * FVB/N 		cornea vascularization J:134428
Gt(ROSA)26Sortm1(Rybp/EGFP)Cve/Gt(ROSA)26Sortm1(Rybp/EGFP)Cve
Tmem163Tg(ACTB-cre)2Mrt/0
involves: 129S1/Sv * 129X1/SvJ * FVB/N 		abnormal vitreous body morphology J:134428
absent eye anterior chamber J:134428
cataract J:134428
coloboma J:134428
cornea vascularization J:134428
retina fold J:134428
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Snrpbem1Lajm/Snrpb+
Tmem163Tg(ACTB-cre)2Mrt/Tmem163+
involves: 129S4/SvJaeSor * C57BL/6J * CD1 * FVB/N 		decreased cranial neural crest cell number J:326544
increased cranial neural crest cell apoptosis J:326544
Gt(ROSA)26Sortm7(CAG-mCherry,-EGFP/tetX)Dym/Gt(ROSA)26Sor+
Tmem163Tg(ACTB-cre)2Mrt/0
Tg(ACTFLPe)9205Dym/0
involves: 129S6/SvEvTac * C57BL/6 * FVB/N * SJL 		perinatal lethality J:154944
Gt(ROSA)26Sortm7(CAG-mCherry,-EGFP/tetX)Dym/Gt(ROSA)26Sor+
Tmem163Tg(ACTB-cre)2Mrt/0
Tg(Fev-flpe)1Dym/0
involves: 129S6/SvEvTac * FVB/N 		abnormal axon morphology J:154944
abnormal breathing pattern J:231745
abnormal oxygen consumption J:231745
decreased anxiety-related response J:154944
decreased body size J:231745
decreased heart rate J:231745
enhanced contextual conditioning behavior J:154944
hypopnea J:231745
increased exploration in new environment J:154944
increased prepulse inhibition J:154944
increased pulmonary ventilation J:231745
increased susceptibility to induced morbidity/mortality J:231745
increased tidal volume J:231745
Kmt2dtm1.1Kaig/Kmt2d+
Tmem163Tg(ACTB-cre)2Mrt/0
B6.Cg-Kmt2dtm1.1Kaig Tg(ACTB-cre)2Mrt 		abnormal heart echocardiography feature J:229890
normal cardiovascular system phenotype J:229890
Kmt2dtm1.1Kaig/Kmt2dtm1.1Kaig
Tmem163Tg(ACTB-cre)2Mrt/0
B6.Cg-Kmt2dtm1.1Kaig Tg(ACTB-cre)2Mrt 		absent head fold J:229890
absent somites J:229890
embryonic lethality between somite formation and embryo turning, complete penetrance J:229890
Lhx2tm1Monu/Lhx2tm1Monu
Tmem163Tg(ACTB-cre)2Mrt/0
involves: 129P2/OlaHsd * CD-1 * FVB/N 		abnormal cerebral cortex morphology J:130167
abnormal telencephalon development J:130167
Lhx8tm1Vpa/Lhx8tm2.1Vpa
Tmem163Tg(ACTB-cre)2Mrt/0
involves: 129P2/OlaHsd * 129S4/SvJae * FVB/N 		abnormal brain interneuron morphology J:182013
abnormal striatum morphology J:182013
Nfasctm2Bhat/Nfasctm2Bhat
Tmem163Tg(ACTB-cre)2Mrt/0
involves: FVB/N 		abnormal paranode morphology J:159621
Noc2ltm1.1Arte/Noc2ltm1.2Arte
Tmem163Tg(ACTB-cre)2Mrt/0
involves: FVB/N 		embryonic lethality prior to tooth bud stage, complete penetrance J:216490
Nogtm1.1Rmh/Nogtm1.1Rmh
Tmem163Tg(ACTB-cre)2Mrt/0
involves: 129P2/OlaHsd * C57BL/6 * FVB/N * SJL 		abnormal cartilage development J:169133
abnormal cartilage morphology J:169133
abnormal rib morphology J:169133
abnormal skeleton development J:169133
abnormal vertebrae morphology J:169133
Nxf2tm1.1JwNxf3tm1.1Jw/Y
Tmem163Tg(ACTB-cre)2Mrt/0
involves: 129S4/SvJae * C57BL/6 * FVB/N 		neonatal lethality, complete penetrance J:199138
Orc4tm1c(EUCOMM)Wtsi/Orc4tm1c(EUCOMM)Wtsi
Tmem163Tg(ACTB-cre)2Mrt/Tmem163+
involves: C57BL/6N * FVB/N 		abnormal female meiosis J:326522
abnormal oocyte morphology J:326522
abnormal polar body morphology J:326522
female infertility J:326522
Pbx1tm1.1Koss/Pbx1tm1.2Koss
Tmem163Tg(ACTB-cre)2Mrt/0
involves: 129P2/OlaHsd * FVB/N 		abnormal deltoid tuberosity morphology J:184521
abnormal humerus morphology J:184521
abnormal rib morphology J:184521
abnormal scapula morphology J:184521
absent spleen J:184521
rib fusion J:184521
scapular bone hypoplasia J:184521
short ribs J:184521
Pthlhtm1Ack/Pthlhtm1.1Ack
Tmem163Tg(ACTB-cre)2Mrt/0
involves: 129S1/Sv * 129X1/SvJ * BALB/c * FVB/N 		abnormal long bone epiphyseal plate morphology J:69396
abnormal long bone epiphyseal plate proliferative zone J:69396
distended abdomen J:69396
domed cranium J:69396
neonatal lethality, complete penetrance J:69396
premature endochondral bone ossification J:69396
protruding tongue J:69396
respiratory failure J:69396
short mandible J:69396
small thoracic cavity J:69396
Pthlhtm1Ack/Pthlhtm1Hmk
Tmem163Tg(ACTB-cre)2Mrt/0
involves: 129 * BALB/c * FVB/N 		abnormal long bone epiphyseal plate morphology J:69396
abnormal long bone epiphyseal plate proliferative zone J:69396
disorganized long bone epiphyseal plate J:69396
distended abdomen J:69396
domed cranium J:69396
neonatal lethality, complete penetrance J:69396
premature endochondral bone ossification J:69396
protruding tongue J:69396
respiratory failure J:69396
short mandible J:69396
small thoracic cavity J:69396
Raph1tm1.1Makr/Raph1tm1.1Makr
Tmem163Tg(ACTB-cre)2Mrt/0
involves: C57BL/6 * C57BL/6NTac * FVB/N 		belly spot J:208191
decreased body size J:208191
postnatal lethality, incomplete penetrance J:208191
Raph1tm1.1Makr/Raph1tm1.1Makr
Tmem163Tg(ACTB-cre)2Mrt/0
Tg(Dct-lacZ)A12Jkn/Tg(Dct-lacZ)A12Jkn
involves: C57BL/6 * C57BL/6NTac * CBA * FVB/N 		belly spot J:208191
decreased body size J:208191
decreased melanocyte number J:208191
Setd5tm1c(EUCOMM)Wtsi/Setd5+
Tmem163Tg(ACTB-cre)2Mrt/Tmem163+
involves: C57BL/6N * FVB/N 		abnormal cardiac outflow tract development J:314464
double outlet right ventricle J:314464
overriding aortic valve J:314464
perimembraneous ventricular septal defect J:314464
Setd5tm1c(EUCOMM)Wtsi/Setd5+
Tbx1tm1Bld/Tbx1+
Tmem163Tg(ACTB-cre)2Mrt/Tmem163+
involves: 129S7/SvEvBrd * C57BL/6 * FVB/N 		abnormal cardiac outflow tract development J:314464
abnormal right subclavian artery morphology J:314464
double outlet right ventricle J:314464
normal mortality/aging J:314464
overriding aortic valve J:314464
perimembraneous ventricular septal defect J:314464
Snrpbem1Lajm/Snrpb+
Tmem163Tg(ACTB-cre)2Mrt/Tmem163+
involves: C57BL/6J * CD1 * FVB/N 		prenatal lethality, complete penetrance J:326544
Tcf4tm1Hmb/Tcf4+
Tmem163Tg(ACTB-cre)2Mrt/Tmem163+
involves: 129P2/OlaHsd * C57BL/6 * FVB/N 		abnormal habituation to a new environment J:254983
decreased anxiety-related response J:254983
decreased body weight J:254983
decreased prepulse inhibition J:254983
decreased startle reflex J:254983
enhanced long-term potentiation J:254983
enhanced NMDA-mediated synaptic currents J:254983
impaired spatial learning J:254983
increased locomotor activity J:254983
Tex11tm1Jw/Tex11tm1Jw
Tmem163Tg(ACTB-cre)2Mrt/0
involves: 129S4/SvJae * C57BL/6 * FVB/N 		abnormal chiasmata formation J:131722
decreased litter size J:131722
Tex11tm1Jw/Y
Tmem163Tg(ACTB-cre)2Mrt/0
involves: 129S4/SvJae * C57BL/6 * FVB/N 		abnormal chiasmata formation J:131722
arrest of male meiosis J:131722
decreased testis weight J:131722
increased male germ cell apoptosis J:131722
male infertility J:131722
meiotic nondisjunction during M1 phase J:131722
Tmem163Tg(ACTB-cre)2Mrt/0
Tg(Thy1-EYFP)15Jrs/0
involves: C57BL/6 * CBA * FVB/N 		normal nervous system phenotype J:89596
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory