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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		1700016L21Rik
RIKEN cDNA 1700016L21 gene
MGI:1919458
49 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background		 Annotated Term Reference
1700016L21RikTg(Itgax-HBEGF/EGFP)57Lan/0
B6.FVB-1700016L21RikTg(Itgax-HBEGF/EGFP)57Lan 		abnormal circulating cytokine level J:194800
abnormal susceptibility to infection J:194800
decreased dendritic cell number J:194800
decreased neutrophil cell number J:194800
impaired neutrophil recruitment J:194800
increased monocyte cell number J:194800
increased neutrophil cell number J:194800
increased susceptibility to bacterial infection J:194800
1700016L21RikTg(Itgax-HBEGF/EGFP)57Lan/0
B6.FVB-1700016L21RikTg(Itgax-HBEGF/EGFP)57Lan/J 		abnormal NK cell physiology J:96123
abnormal NK T cell physiology J:96123
decreased circulating interferon-gamma level J:96123
decreased circulating interleukin-12 level J:96123
decreased dendritic cell number J:96123, J:100867, J:113232
decreased interferon-gamma secretion J:96123
decreased interleukin-4 secretion J:96123
decreased interleukin-12b secretion J:125611
normal immune system phenotype J:96123, J:122114
impaired natural killer cell mediated cytotoxicity J:125611
increased susceptibility to induced morbidity/mortality J:113232
sepsis J:113232
1700016L21RikTg(Itgax-HBEGF/EGFP)57Lan/0
C.FVB-1700016L21RikTg(Itgax-HBEGF/EGFP)57Lan 		abnormal CD8-positive, alpha-beta T cell differentiation J:93488
abnormal T cell activation J:93488
decreased CD8-positive, alpha-beta T cell number J:93488
decreased cytotoxic T cell cytolysis J:93488
decreased dendritic cell number J:93488
increased neutrophil cell number J:194800
premature death J:93488
1700016L21RikTg(Itgax-HBEGF/EGFP)57Lan/0
C.FVB-1700016L21RikTg(Itgax-HBEGF/EGFP)57Lan/J 		abnormal NK cell physiology J:96123
decreased circulating interferon-gamma level J:96123
decreased circulating interleukin-12 level J:96123
decreased dendritic cell number J:96123
decreased interferon-gamma secretion J:96123
normal immune system phenotype J:96123
1700016L21RikTg(Itgax-HBEGF/EGFP)57Lan/0
involves: C57BL/6 * FVB/N 		abnormal alveolar macrophage morphology J:137452
decreased dendritic cell number J:137452
decreased interferon-gamma secretion J:137452
increased susceptibility to Orthomyxoviridae infection J:137452
1700016L21RikTg(Itgax-HBEGF/EGFP)57Lan/0
involves: FVB/N 		abnormal response to infection J:189122
decreased gamma-delta T cell number J:193548
decreased interleukin-17 secretion J:193548
decreased leukocyte cell number J:193548
decreased neutrophil cell number J:193548
decreased physiological sensitivity to xenobiotic J:193548
decreased susceptibility to bacterial infection J:210086
decreased T cell number J:193548
1700016L21RikTg(Itgax-HBEGF/EGFP)57Lan/0
NOD.FVB-1700016L21RikTg(Itgax-HBEGF/EGFP)57Lan/Jdk 		abnormal professional antigen presenting cell physiology J:137009
cachexia J:137009
decreased dendritic cell number J:137009
decreased macrophage cell number J:137009
decreased NK T cell number J:137009
decreased susceptibility to autoimmune diabetes J:137009
normal endocrine/exocrine gland phenotype J:137009
increased interferon-gamma secretion J:137009
increased tumor necrosis factor secretion J:137009
insulitis J:137009
premature death J:137009
Siglec1tm1(HBEGF)Mtka/Siglec1tm1(HBEGF)Mtka
1700016L21RikTg(Itgax-HBEGF/EGFP)57Lan/?
involves: 129S1/Sv * 129X1/SvJ * FVB/N 		abnormal dendritic cell physiology J:123958
abnormal immune system physiology J:123958
abnormal immune tolerance J:123958
abnormal macrophage physiology J:123958
abnormal metallophilic macrophage morphology J:123958
abnormal spleen marginal zone macrophage morphology J:123958
Tg(Ins2-TFRC/OVA)296Wehi/0
1700016L21RikTg(Itgax-HBEGF/EGFP)57Lan/0
involves: C57BL/6 * FVB 		decreased T cell proliferation J:122114
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory