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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Plekhf1
pleckstrin homology domain containing, family F (with FYVE domain) member 1
MGI:1919537
9 phenotypes from 2 alleles in 2 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Plekhf1em1(IMPC)Wtsi/Plekhf1em1(IMPC)Wtsi
C57BL/6N-Plekhf1em1(IMPC)Wtsi/Wtsi 		preweaning lethality, complete penetrance J:211773
Plekhf1tm1.1Caox/Plekhf1tm1.1Caox
Lyz2tm1(cre)Ifo/Lyz2+
B6.Cg-Plekhf1tm1.1Caox Lyz2tm1(cre)Ifo 		abnormal cytokine secretion J:277440
abnormal endocytosis J:277440
abnormal macrophage physiology J:277440
decreased circulating interferon-beta level J:277440
decreased circulating interleukin-6 level J:277440
decreased circulating tumor necrosis factor level J:277440
increased susceptibility to bacterial infection J:277440
increased susceptibility to bacterial infection induced morbidity/mortality J:277440
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory