Tmem175 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Tmem175
transmembrane protein 175
MGI:1919642

14 phenotypes from 4 alleles in 4 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Tmem175^em1Dren/Tmem175⁺ B6.Cg-Tmem175^em1Dren	abnormal lysosome physiology	J:304120
	abnormal nervous system tract morphology	J:304120
	impaired coordination	J:304120
	loss of dopaminergic neurons	J:304120
Tmem175^em1Dren/Tmem175^em1Dren B6.Cg-Tmem175^em1Dren	abnormal autophagy	J:304120
	abnormal lysosome physiology	J:304120
	abnormal neuron physiology	J:304120
	increased cellular sensitivity to hydrogen peroxide	J:304120
	increased susceptibility to neuronal excitotoxicity	J:304120
	loss of dopaminergic neurons	J:304120
Tmem175^em2Dren/Tmem175⁺ C57BL/6J-Tmem175^em2Dren	abnormal lysosome physiology	J:304120
Tmem175^em2Dren/Tmem175^em2Dren C57BL/6J-Tmem175^em2Dren	abnormal lysosome physiology	J:304120
	decreased cellular sensitivity to hydrogen peroxide	J:304120
	decreased susceptibility to neuronal excitotoxicity	J:304120
Tmem175^em3Dren/Tmem175⁺ C57BL/6J-Tmem175^em3Dren	abnormal lysosome physiology	J:304120
	alpha-synuclein inclusion body	J:304120
	increased susceptibility to neuronal excitotoxicity	J:304120
Tmem175^em3Dren/Tmem175^em3Dren C57BL/6J-Tmem175^em3Dren	abnormal lysosome physiology	J:304120
	alpha-synuclein inclusion body	J:304120
	increased susceptibility to neuronal excitotoxicity	J:304120
Tmem175^{tm1b(KOMP)Wtsi}/Tmem175^{tm1b(KOMP)Wtsi} C57BL/6N-Tmem175^{tm1b(KOMP)Wtsi}/Kmpc	abnormal coat/hair pigmentation	J:211773
	abnormal seminal vesicle morphology	J:211773
	increased circulating aspartate transaminase level	J:211773

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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