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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Spink5
serine peptidase inhibitor, Kazal type 5
MGI:1919682
26 phenotypes from 5 alleles in 5 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Spink5em1(IMPC)J/Spink5+
C57BL/6NJ-Spink5em1(IMPC)J/Mmjax 		absent vibrissae J:211773
Spink5em1(IMPC)J/Spink5em1(IMPC)J
C57BL/6NJ-Spink5em1(IMPC)J/Mmjax 		preweaning lethality, complete penetrance J:211773
Spink5m1Btlr/Spink5m1Btlr
involves: C57BL/6J 		flaky skin J:183755
increased neutrophil cell number J:183755
scaly skin J:183755
skin lesions J:183755
Spink5tm1Drh/Spink5tm1Drh
involves: 129P2/OlaHsd * C57BL/6 		abnormal corneocyte envelope morphology J:95549
abnormal epidermal layer morphology J:95549
dehydration J:95549
hyperkeratosis J:95549
impaired skin barrier function J:95549
neonatal lethality, complete penetrance J:95549
Spink5tm1Hov/Spink5tm1Hov
involves: 129P2/OlaHsd * FVB 		abnormal epidermal layer morphology J:96435
abnormal epidermis stratum corneum morphology J:96435
abnormal epidermis stratum granulosum morphology J:96435
abnormal hair follicle morphology J:96435
abnormal hair shaft morphology J:96435
abnormal vibrissa follicle morphology J:96435
abnormal vibrissa morphology J:96435
acanthosis J:96435
decreased skin tensile strength J:96435
epidermal desquamation J:96435
hyperkeratosis J:96435
impaired skin barrier function J:96435
neonatal lethality, complete penetrance J:96435
parakeratosis J:96435
reddish skin J:96435
scaly skin J:96435
skin lesions J:96435
sparse vibrissae J:96435
Spink5Tn(Pgk2-sb10,sb-Tyr)1498Ove/Spink5Tn(Pgk2-sb10,sb-Tyr)1498Ove
involves: FVB/N 		abnormal epidermis stratum corneum morphology J:93050
abnormal epidermis stratum granulosum morphology J:93050
blistering J:93050
dehydration J:93050
impaired skin barrier function J:93050
normal integument phenotype J:93050
neonatal lethality, complete penetrance J:93050
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory