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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Smg1
SMG1 nonsense mediated mRNA decay associated PI3K related kinase
MGI:1919742
43 phenotypes from 3 alleles in 3 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Smg1Gt(AG0297)Wtsi/Smg1+
involves: 129P2/OlaHsd * C57BL/6 		abnormal basicranium angle J:193626
abnormal kidney morphology J:193626
abnormal tooth development J:193626
abnormal tooth morphology J:193626
normal cellular phenotype J:193626
chronic inflammation J:193626
decreased circulating interleukin-1 beta level J:193626
decreased tumor-free survival time J:193626
enlarged liver J:193626
enlarged spleen J:193626
normal hematopoietic system phenotype J:193626
hepatic steatosis J:193626
normal homeostasis/metabolism phenotype J:193626
increased B cell derived lymphoma incidence J:193626
increased body length J:193626
increased body size J:193626
increased body weight J:193626
increased circulating interleukin-6 level J:193626
increased lung adenocarcinoma incidence J:193626
increased lymphoma incidence J:193626
increased tumor incidence J:193626
prognathia J:193626
normal skeleton phenotype J:193626
Smg1Gt(AG0297)Wtsi/Smg1Gt(AG0297)Wtsi
involves: 129P2/OlaHsd * C57BL/6 		embryonic lethality between implantation and placentation, complete penetrance J:193626
Smg1Gt(RRT449)Byg/Smg1Gt(RRT449)Byg
B6.129P2-Smg1Gt(RRT449)Byg 		abnormal cardiovascular development J:196053
abnormal cell physiology J:196053
abnormal eye development J:196053
abnormal heart development J:196053
absent optic pit J:196053
decreased cell proliferation J:196053
decreased embryo size J:196053
delayed brain development J:196053
delayed embryo turning J:196053
embryonic growth arrest J:196053
embryonic lethality during organogenesis, complete penetrance J:196053
failure of heart looping J:196053
increased embryonic tissue cell apoptosis J:196053
internal hemorrhage J:196053
Smg1tm1b(EUCOMM)Hmgu/Smg1+
C57BL/6N-Smg1tm1b(EUCOMM)Hmgu/Wtsi 		increased circulating bilirubin level J:211773
Smg1tm1b(EUCOMM)Hmgu/Smg1tm1b(EUCOMM)Hmgu
C57BL/6N-Smg1tm1b(EUCOMM)Hmgu/Wtsi 		abnormal trophoblast layer morphology J:261316
embryonic lethality during organogenesis, incomplete penetrance J:261316
lethality throughout fetal growth and development, complete penetrance J:261316
preweaning lethality, complete penetrance J:211773
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
10/29/2024
MGI 6.24 		The Jackson Laboratory