Aldh1b1 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Aldh1b1
aldehyde dehydrogenase 1 family, member B1
MGI:1919785

23 phenotypes from 3 alleles in 3 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Aldh1b1^{tm1.1(KOMP)Vlcg}/Aldh1b1^{tm1.1(KOMP)Vlcg} involves: C57BL/6J * C57BL/6NTac * CBA	abnormal calcium ion homeostasis	J:232360
	abnormal pancreas development	J:232360
	abnormal pancreatic beta cell differentiation	J:232360
	abnormal pancreatic islet morphology	J:232360
	decreased insulin secretion	J:232360
	normal homeostasis/metabolism phenotype	J:232360
	hyperglycemia	J:232360
	impaired glucose tolerance	J:232360
	increased glucagon secretion	J:232360
	increased insulin secretion	J:232360
	increased pancreatic alpha cell number	J:232360
	increased pancreatic beta cell apoptosis	J:232360
	increased pancreatic beta cell mass	J:232360
	increased pancreatic beta cell proliferation	J:232360
	increased pancreatic delta cell number	J:232360
	increased pancreatic islet cell apoptosis	J:232360
	insulin resistance	J:232360
	oxidative stress	J:232360
	pancreatic islet hyperplasia	J:232360
Aldh1b1^tm1Vvas/Aldh1b1^tm1Vvas B6J.Cg-Aldh1b1^tm1Vvas	abnormal xenobiotic pharmacokinetics	J:228677
	normal endocrine/exocrine gland phenotype	J:228677
	normal homeostasis/metabolism phenotype	J:228677
	increased fasting circulating glucose level	J:228677
Aldh1b1^{tm2a(EUCOMM)Wtsi}/Aldh1b1^{tm2a(EUCOMM)Wtsi} C57BL/6N-Aldh1b1^{tm2a(EUCOMM)Wtsi}/Wtsi	increased grip strength	J:211773

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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