Aldh1b1 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Aldh1b1
aldehyde dehydrogenase 1 family, member B1
MGI:1919785

23 phenotypes from 3 alleles in 3 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Aldh1b1^{tm1.1(KOMP)Vlcg}/Aldh1b1^{tm1.1(KOMP)Vlcg} involves: C57BL/6J * C57BL/6NTac * CBA	abnormal calcium ion homeostasis	J:232360
	abnormal pancreas development	J:232360
	abnormal pancreatic beta cell differentiation	J:232360
	abnormal pancreatic islet morphology	J:232360
	decreased insulin secretion	J:232360
	normal homeostasis/metabolism phenotype	J:232360
	hyperglycemia	J:232360
	impaired glucose tolerance	J:232360
	increased glucagon secretion	J:232360
	increased insulin secretion	J:232360
	increased pancreatic alpha cell number	J:232360
	increased pancreatic beta cell apoptosis	J:232360
	increased pancreatic beta cell mass	J:232360
	increased pancreatic beta cell proliferation	J:232360
	increased pancreatic delta cell number	J:232360
	increased pancreatic islet cell apoptosis	J:232360
	insulin resistance	J:232360
	oxidative stress	J:232360
	pancreatic islet hyperplasia	J:232360
Aldh1b1^tm1Vvas/Aldh1b1^tm1Vvas B6J.Cg-Aldh1b1^tm1Vvas	abnormal xenobiotic pharmacokinetics	J:228677
	normal endocrine/exocrine gland phenotype	J:228677
	normal homeostasis/metabolism phenotype	J:228677
	increased fasting circulating glucose level	J:228677
Aldh1b1^{tm2a(EUCOMM)Wtsi}/Aldh1b1^{tm2a(EUCOMM)Wtsi} C57BL/6N-Aldh1b1^{tm2a(EUCOMM)Wtsi}/Wtsi	increased grip strength	J:211773

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 08/02/2024 MGI 6.24