Pgam5 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Pgam5
phosphoglycerate mutase family member 5
MGI:1919792

37 phenotypes from 4 alleles in 2 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Pgam5^{tm1a(EUCOMM)Wtsi}/Pgam5^{tm1a(EUCOMM)Wtsi} involves: C57BL/6N	abnormal gait	J:225345
	abnormal mitochondrial crista morphology	J:225345
	abnormal mitochondrial morphology	J:225345
	abnormal mitochondrial physiology	J:225345
	abnormal motor coordination/balance	J:225345
	akinesia	J:225345
	bradykinesia	J:225345
	decreased dopamine level	J:225345
	decreased vertical activity	J:225345
	normal homeostasis/metabolism phenotype	J:225345
	loss of dopaminergic neurons	J:225345
	neuron degeneration	J:225345
	oxidative stress	J:225345
	short stride length	J:225345
Pgam5^{tm1b(EUCOMM)Wtsi}/Pgam5^{tm1b(EUCOMM)Wtsi} C57BL/6N-Pgam5^{tm1b(EUCOMM)Wtsi}/Ics	decreased circulating cholesterol level	J:211773
	decreased circulating glucose level	J:211773
	decreased circulating HDL cholesterol level	J:211773
	decreased circulating serum albumin level	J:211773
	decreased circulating total protein level	J:211773
	decreased erythrocyte cell number	J:211773
	decreased exploration in new environment	J:211773
	decreased total retina thickness	J:211773
	increased circulating creatinine level	J:211773
	increased mean corpuscular volume	J:211773
	short tibia	J:211773
Pgam5^{tm1c(EUCOMM)Wtsi}/Pgam5^{tm1c(EUCOMM)Wtsi} involves: C57BL/6N	no abnormal phenotype detected	J:240016
Pgam5^{tm1d(EUCOMM)Wtsi}/Pgam5^{tm1d(EUCOMM)Wtsi} involves: C57BL/6N	abnormal interleukin-1 beta secretion	J:240016
	abnormal macrophage activation involved in immune response	J:240016
	abnormal mitochondrial morphology	J:240016
	abnormal mitochondrial shape	J:240016
	abnormal redox activity	J:240016
	normal cellular phenotype	J:240016
	decreased body size	J:240016
	decreased body weight	J:240016
	decreased interleukin-1 beta secretion	J:240016
	decreased survivor rate	J:240016
	premature death	J:240016
	prenatal lethality, incomplete penetrance	J:240016

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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