Cul4b Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Cul4b
cullin 4B
MGI:1919834

38 phenotypes from 5 alleles in 7 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Cul4b^{Gt(M119G06)Wrst}/Y chimera involves: 129S2/SvPas	abnormal developmental patterning	J:160967
Cul4b^tm1.1Pz/Y involves: 129 * C57BL/6J	no abnormal phenotype detected	J:199210
Cul4b^tm1.1Pz/Cul4b⁺ Tg(CAG-cre)13Miya/0 involves: 129 * C57BL/6 * C57BL/6J	abnormal vitelline vasculature morphology	J:199210
	lethality throughout fetal growth and development, complete penetrance	J:199210
Cul4b^tm1.1Pz/Cul4b⁺ Edil3^{Tg(Sox2-cre)1Amc}/Edil3⁺ involves: 129 * C57BL/6 * C57BL/6J * CBA	normal mortality/aging	J:199210
Cul4b^tm1.1Pz/Cul4b^tm1.1Pz involves: 129 * C57BL/6J	no abnormal phenotype detected	J:199210
Cul4b^tm1.1Pz/Y Edil3^{Tg(Sox2-cre)1Amc}/Edil3⁺ involves: 129 * C57BL/6 * C57BL/6J * CBA	no abnormal phenotype detected	J:199210
Cul4b^tm1.1Pz/Y Tg(CAG-cre)13Miya/0 involves: 129 * C57BL/6 * C57BL/6J	abnormal ectoderm development	J:199210
	abnormal embryo development	J:199210
	absent ectoplacental cone	J:199210
	decreased cell proliferation	J:199210
	decreased embryo size	J:199210
	embryonic growth arrest	J:199210
	embryonic lethality during organogenesis, complete penetrance	J:199210
	failure of primitive streak formation	J:199210
	increased embryonic tissue cell apoptosis	J:199210
Cul4b^tm1.1Yxg/Y involves: 129X1/SvJ * FVB/N	abnormal embryonic tissue morphology	J:199139
	abnormal extraembryonic tissue morphology	J:199139
	decreased cell proliferation	J:199139
	decreased embryo size	J:199139
	disorganized extraembryonic tissue	J:199139
	embryonic growth retardation	J:199139
	embryonic lethality during organogenesis, complete penetrance	J:199139
	increased embryonic tissue cell apoptosis	J:199139
Cul4b^tm1.1Yxg/Cul4b⁺ involves: 129X1/SvJ * FVB/N	abnormal dosage compensation, by inactivation of X chromosome	J:199139
	abnormal placenta labyrinth morphology	J:199139
	abnormal visceral yolk sac morphology	J:199139
	decreased body size	J:199139
	decreased body weight	J:199139
	decreased embryo size	J:199139
	decreased fetal size	J:199139
	disorganized placental labyrinth	J:199139
	embryonic growth retardation	J:199139
	fetal growth retardation	J:199139
	lethality during fetal growth through weaning, incomplete penetrance	J:199139
	lethality throughout fetal growth and development, incomplete penetrance	J:199139
	pale placenta	J:199139
	pallor	J:199139
	postnatal growth retardation	J:199139
	small placenta	J:199139
Cul4b^tm1Swl/Y Edil3^{Tg(Sox2-cre)1Amc}/Edil3⁺ B6.Cg-Edil3^{Tg(Sox2-cre)1Amc} Cul4b^tm1Swl	abnormal dendrite morphology	J:187403
	abnormal dendritic spine morphology	J:187403
	abnormal spatial learning	J:187403
	decreased neuron number	J:187403
	impaired spatial working memory	J:187403
	increased susceptibility to pharmacologically induced seizures	J:187403
Cul4b^tm1Yxg/Y involves: 129X1/SvJ	no abnormal phenotype detected	J:199139
Cul4b^tm1Yxg/Cul4b^tm1Yxg involves: 129X1/SvJ	no abnormal phenotype detected	J:199139

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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