Topbp1 Phenotype Annotations

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Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Topbp1
topoisomerase (DNA) II binding protein 1
MGI:1920018

9 phenotypes from 4 alleles in 4 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Emx1^tm1(cre)Krj/Emx1⁺ Topbp1^tm1Pmc/Topbp1^tm1Pmc involves: 129S2/SvPas * C57BL/6J	abnormal cerebral cortex morphology	J:181920
Topbp1^tm1.1Dsh/Topbp1^tm1.1Dsh involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6	no abnormal phenotype detected	J:170406
Topbp1^tm1.1Dsh/Topbp1^tm1.1Dsh involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6	abnormal cell cycle	J:170406
	abnormal cell physiology	J:170406
Topbp1^tm1.1Zqw/Topbp1^tm1.1Zqw involves: 129P2/OlaHsd * 129S4/SvJaeSor	embryonic growth arrest	J:200981
	embryonic lethality before implantation, complete penetrance	J:200981
Topbp1^tm1.2Dsh/Topbp1^tm1.2Dsh involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6 * C57BL/6J	decreased cell proliferation	J:170406
	embryonic growth arrest	J:170406
	embryonic lethality at implantation, complete penetrance	J:170406
	increased embryonic tissue cell apoptosis	J:170406

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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