Tdp1 Phenotype Annotations

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Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Tdp1
tyrosyl-DNA phosphodiesterase 1
MGI:1920036

13 phenotypes from 2 alleles in 4 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Tdp1^em1(IMPC)Tcp/Tdp1^em1(IMPC)Tcp C57BL/6NCrl-Tdp1^em1(IMPC)Tcp/Tcp	decreased exploration in new environment	J:211773
	decreased mean corpuscular volume	J:211773
	enlarged lymph nodes	J:211773
	increased mean corpuscular hemoglobin concentration	J:211773
	increased red blood cell distribution width	J:211773
Tdp1^Gt(XD105)Byg/Tdp1^Gt(XD105)Byg involves: 129P2/OlaHsd	abnormal DNA repair	J:170077
Tdp1^Gt(XD105)Byg/Tdp1^Gt(XD105)Byg involves: 129P2/OlaHsd * 129S/SvEv	normal behavior/neurological phenotype	J:127602
	increased physiological sensitivity to xenobiotic	J:127602
Tdp1^Gt(XD105)Byg/Tdp1^Gt(XD105)Byg involves: 129P2/OlaHsd * C57BL/6	abnormal neuron physiology	J:127605
	abnormal single-strand DNA break repair	J:127605
	normal behavior/neurological phenotype	J:127605
	decreased circulating serum albumin level	J:127605
	normal homeostasis/metabolism phenotype	J:127605
	increased physiological sensitivity to xenobiotic	J:127605
	small cerebellum	J:127605

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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