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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Appl1
adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1
MGI:1920243
21 phenotypes from 4 alleles in 5 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Appl1Gt(RRS819)Byg/Appl1Gt(RRS819)Byg
involves: 129P2/OlaHsd * C57BL/6 		abnormal brown adipose tissue physiology J:211794
abnormal hepatic glucose production J:211794
normal behavior/neurological phenotype J:211794
normal growth/size/body region phenotype J:211794
normal homeostasis/metabolism phenotype J:211794
hyperactivity J:211794
impaired glucose tolerance J:211794
increased circulating insulin level J:211794
increased core body temperature J:211794
increased fasting circulating glucose level J:211794
insulin resistance J:211794
Appl1Gt(XM073)Byg/Appl1Gt(XM073)Byg
B6.129P2-Appl1Gt(XM073)Byg 		normal homeostasis/metabolism phenotype J:164696
normal immune system phenotype J:164696
increased T cell proliferation J:164696
Appl1tm1.2Test/Appl1tm1.2Test
involves: 129X1/SvJ 		abnormal cell physiology J:227340
decreased fibroblast cell migration J:227340
normal hematopoietic system phenotype J:227340
increased hematocrit J:227340
increased T cell proliferation J:164696
Appl1tm1.2Test/Appl1tm1.2Test
involves: 129X1/SvJ * C57BL/6 		normal cellular phenotype J:159889
decreased fibroblast cell migration J:159889
normal hematopoietic system phenotype J:159889
increased sensitivity to induced cell death J:159889
Appl1tm1Ymli/Appl1tm1Ymli
involves: 129S1/Sv * C57BL/6J 		decreased vasodilation J:189487
increased vasoconstriction J:189487
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory