Nfatc4 Phenotype Annotations - Multigenic Genotypes

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Nfatc4
nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 4
MGI:1920431

39 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Nfatc2^tm1Glm/Nfatc2^tm1Glm Nfatc3^tm1Glm/Nfatc3^tm1Glm Nfatc4^tm1Grc/Nfatc4^tm1Grc involves: 129S2/SvPas	abnormal locomotor activation	J:109139
	abnormal sensory neuron innervation pattern	J:83744
	abnormal social/conspecific interaction behavior	J:109139
	abnormal spinal cord dorsal column morphology	J:83744
	abnormal trigeminal nerve morphology	J:83744
	decreased anxiety-related response	J:109139
	decreased embryo size	J:83744
	decreased grip strength	J:109139
	hypotonia	J:109139
Nfatc2^tm1Glm/Nfatc2^tm1Glm Nfatc4^tm1Grc/Nfatc4^tm1Grc involves: 129S2/SvPas	abnormal cranium morphology	J:109139
	abnormal locomotor activation	J:109139
	abnormal mandible morphology	J:109139
	abnormal neurocranium morphology	J:109139
	abnormal social/conspecific interaction behavior	J:109139
	abnormal zygomatic arch morphology	J:109139
	decreased anxiety-related response	J:109139
	decreased grip strength	J:109139
	hypotonia	J:109139
Nfatc3^tm1Glm/Nfatc3^tm1Glm Nfatc4^tm1Grc/Nfatc4^tm1Grc involves: 129S2/SvPas	abnormal blood vessel morphology	J:70266
	abnormal heart morphology	J:84138
	abnormal intersomitic vessel morphology	J:70266
	abnormal placental labyrinth vasculature morphology	J:109139
	abnormal sensory neuron innervation pattern	J:83744
	abnormal vitelline vasculature morphology	J:70266
	aganglionic megacolon	J:109139
	annular pancreas	J:109139
	embryonic lethality during organogenesis, incomplete penetrance	J:70266
	enlarged heart	J:84138
	enlarged pericardium	J:70266
	trabecula carnea hypoplasia	J:84138
Nfatc3^tm1Glm/Nfatc3^tm1Glm Nfatc4^tm1Jmk/Nfatc4^tm1Jmk involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6	abnormal cardiovascular system physiology	J:84138
	abnormal cellular respiration	J:84138
	abnormal heart development	J:84138
	abnormal heart morphology	J:84138
	abnormal heart ventricle morphology	J:84138
	abnormal myocardial fiber mitochondrial morphology	J:84138
	abnormal myocardium compact layer morphology	J:84138
	abnormal myocardium layer morphology	J:84138
	abnormal trabecula carnea morphology	J:84138
	anemia	J:84138
	dilated heart	J:84138
	embryonic growth retardation	J:84138
	embryonic lethality during organogenesis, complete penetrance	J:84138
Nfatc3^tm1Glm/Nfatc3^tm1Glm Nfatc4^tm1Jmk/Nfatc4^tm1Jmk Tg(Myh6-NFATC4)#Eno/? involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6 * FVB	normal cardiovascular system phenotype	J:84138
	embryonic lethality during organogenesis, complete penetrance	J:84138
Nfatc3^tm1Glm/Nfatc3^tm1Glm Nfatc4^tm1Jmk/Nfatc4^tm1Jmk Tg(TIE2-lacZ)182Sato/? involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6	abnormal dorsal aorta morphology	J:84138
Nfatc4^tm1Jmk/Nfatc4^tm1Jmk Tg(Myh6-Ppp3ca)37Eno/? involves: 129S7/SvEvBrd * C57BL/6 * FVB	abnormal myocardium layer morphology	J:79608
	cardiac hypertrophy	J:79608
	dilated heart	J:79608

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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