Arhgef6 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Arhgef6
Rac/Cdc42 guanine nucleotide exchange factor 6
MGI:1920591

22 phenotypes from 3 alleles in 3 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Arhgef6^tm1Kdf/Arhgef6^tm1Kdf involves: 129P2/OlaHsd * C57BL/6	abnormal B cell number	J:137269
	abnormal humoral immune response	J:137269
	abnormal T cell physiology	J:137269
	decreased B cell proliferation	J:137269
	decreased CD4-positive, alpha-beta T cell number	J:137269
	decreased CD8-positive, alpha-beta T cell number	J:137269
	decreased interleukin-2 secretion	J:137269
	decreased lymphocyte cell number	J:137269
	decreased mature B cell number	J:137269
	decreased T cell proliferation	J:137269
	enhanced B cell migration	J:137269
Arhgef6^tm1Kkut/Y B6.129-Arhgef6^tm1Kkut	abnormal dendrite morphology	J:179026
	abnormal dendritic spine morphology	J:179026
	abnormal long-term depression	J:179026
	abnormal response to novel object	J:179026
	abnormal spatial learning	J:179026
	abnormal synapse morphology	J:179026
	normal behavior/neurological phenotype	J:179026
	reduced long-term potentiation	J:179026
Arhgef6^{tm2e.1(EUCOMM)Wtsi}/Y C57BL/6N-Arhgef6^{tm2e.1(EUCOMM)Wtsi}/Tcp	enlarged lymph nodes	J:211773
Arhgef6^{tm2e.1(EUCOMM)Wtsi}/Arhgef6^{tm2e.1(EUCOMM)Wtsi} C57BL/6N-Arhgef6^{tm2e.1(EUCOMM)Wtsi}/Tcp	decreased lymphocyte cell number	J:211773
	increased circulating aspartate transaminase level	J:211773
	increased circulating potassium level	J:211773

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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