Ddx46 Phenotype Annotations

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Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Ddx46
DEAD box helicase 46
MGI:1920895

16 phenotypes from 2 alleles in 2 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Ddx46^em1(IMPC)Tcp/Ddx46⁺ C57BL/6N-Ddx46^em1(IMPC)Tcp/Tcp	decreased mean corpuscular hemoglobin	J:211773
Ddx46^em1(IMPC)Tcp/Ddx46⁺ C57BL/6N-Ddx46^em1(IMPC)Tcp/Tcp	enlarged lymph nodes	J:211773
Ddx46^em1(IMPC)Tcp/Ddx46^em1(IMPC)Tcp C57BL/6N-Ddx46^em1(IMPC)Tcp/Tcp	embryonic lethality prior to organogenesis	J:211773
	preweaning lethality, complete penetrance	J:211773
Ddx46^em1Caox/Ddx46⁺ involves: C57BL/6J	abnormal innate immunity	J:271836
	abnormal macrophage physiology	J:271836
	decreased body size	J:271836
	decreased susceptibility to Riboviria infection	J:271836
	increased circulating interferon-beta level	J:271836
	increased interferon-beta secretion	J:271836
	increased interleukin-1 beta secretion	J:271836
	increased interleukin-6 secretion	J:271836
	increased macrophage cytokine production	J:271836
	increased tumor necrosis factor secretion	J:271836
	normal mortality/aging	J:271836
Ddx46^em1Caox/Ddx46^em1Caox involves: C57BL/6J	prenatal lethality, complete penetrance	J:271836

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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