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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Ddx46
DEAD box helicase 46
MGI:1920895
18 phenotypes from 2 alleles in 2 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Ddx46em1(IMPC)Tcp/Ddx46+
C57BL/6N-Ddx46em1(IMPC)Tcp/Cmmr 		decreased mean corpuscular hemoglobin J:211773
enlarged lymph nodes J:211773
Ddx46em1(IMPC)Tcp/Ddx46em1(IMPC)Tcp
C57BL/6N-Ddx46em1(IMPC)Tcp/Cmmr 		abnormal embryo implantation J:279207
embryonic lethality between implantation and somite formation, complete penetrance J:279207
embryonic lethality prior to organogenesis J:211773
preweaning lethality, complete penetrance J:211773
Ddx46em1Caox/Ddx46+
involves: C57BL/6J 		abnormal innate immunity J:271836
abnormal macrophage physiology J:271836
decreased body size J:271836
decreased susceptibility to Riboviria infection J:271836
increased circulating interferon-beta level J:271836
increased interferon-beta secretion J:271836
increased interleukin-1 beta secretion J:271836
increased interleukin-6 secretion J:271836
increased macrophage cytokine production J:271836
increased tumor necrosis factor secretion J:271836
normal mortality/aging J:271836
Ddx46em1Caox/Ddx46em1Caox
involves: C57BL/6J 		prenatal lethality, complete penetrance J:271836
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory