Tmtc4 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Tmtc4
transmembrane and tetratricopeptide repeat containing 4
MGI:1921050

21 phenotypes from 2 alleles in 3 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Tmtc4^{tm1(KOMP)Vlcg}/Tmtc4^{tm1(KOMP)Vlcg} FVB.B6-Tmtc4^{tm1(KOMP)Vlcg}	impaired hearing	J:268046
	increased or absent threshold for auditory brainstem response	J:268046
Tmtc4^{tm1(KOMP)Vlcg}/Tmtc4^{tm1(KOMP)Vlcg} involves: C57BL/6J * C57BL/6NTac	abnormal auditory brainstem response waveform shape	J:268046
	abnormal calcium ion homeostasis	J:268046
	abnormal endoplasmic reticulum physiology	J:268046
	absent distortion product otoacoustic emissions	J:268046
	cochlear degeneration	J:268046
	cochlear ganglion degeneration	J:268046
	cochlear hair cell degeneration	J:268046
	cochlear inner hair cell degeneration	J:268046
	cochlear outer hair cell degeneration	J:268046
	degeneration of organ of Corti supporting cells	J:268046
	increased endoplasmic reticulum stress	J:268046
	increased or absent threshold for auditory brainstem response	J:268046
	increased sensitivity to induced cell death	J:268046
	organ of Corti degeneration	J:268046
	sensorineural hearing loss	J:268046
Tmtc4^{tm1.1(KOMP)Vlcg}/Tmtc4^{tm1.1(KOMP)Vlcg} C57BL/6N-Tmtc4^{tm1.1(KOMP)Vlcg}/Ucd	abnormal auditory brainstem response	J:211773
	abnormal startle reflex	J:211773
	decreased fasting circulating glucose level	J:211773
	decreased prepulse inhibition	J:211773
	decreased startle reflex	J:211773

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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