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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Psmb11
proteasome (prosome, macropain) subunit, beta type, 11
MGI:1921152
27 phenotypes from 3 alleles in 3 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Psmb11em1(IMPC)Ccpcz/Psmb11em1(IMPC)Ccpcz
C57BL/6NCrl-Psmb11em1(IMPC)Ccpcz/Ccpcz 		abnormal colon morphology J:211773
abnormal digit morphology J:211773
abnormal heart morphology J:211773
abnormal ileum morphology J:211773
abnormal skin morphology J:211773
abnormal spleen morphology J:211773
abnormal testis morphology J:211773
abnormal thymus morphology J:211773
decreased CD8-positive, alpha-beta T cell number J:211773
decreased effector memory T-helper cell number J:211773
enlarged heart J:211773
enlarged spleen J:211773
enlarged thymus J:211773
increased CD4-positive NK T cell number J:211773
increased CD4-positive, alpha-beta T cell number J:211773
increased effector memory CD8-positive, alpha-beta T cell number J:211773
increased effector memory T-helper cell number J:211773
increased memory-marker CD4-positive NK T cell number J:211773
increased NK T cell number J:211773
increased T-helper cell number J:211773
small testis J:211773
Psmb11tm1(Psmb8)Khog/Psmb11+
involves: C57BL/6 		decreased CD8-positive, alpha-beta T cell number J:196156
Psmb11tm1(Psmb8)Khog/Psmb11tm1(Psmb8)Khog
involves: C57BL/6 		abnormal CD8-positive, alpha beta T cell morphology J:196156
abnormal self tolerance J:196156
abnormal T cell differentiation J:196156
abnormal T cell receptor V(D)J recombination J:196156
decreased CD8-positive, alpha-beta T cell number J:196156
decreased memory T cell number J:196156
increased T cell proliferation J:196156
Psmb11tm1Smta/Psmb11tm1Smta
involves: C57BL/6 * CBA 		decreased CD8-positive, alpha-beta T cell number J:121869
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory